Impaired lymphocyte profile in schistosomiasis patients with periportal fibrosis

Detalhes bibliográficos
Autor(a) principal: Cardoso, Luciana Santos
Data de Publicação: 2013
Outros Autores: Barreto, Andréia de Sousa Rocha, Fernandes, Jamille Souza, Oliveira, Ricardo Riccio, Souza, Robson da Paixão de, Carvalho Filho, Edgar Marcelino de, Araujo, Maria Ilma Andrade Santos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/15885
Resumo: p. 1-8
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spelling Cardoso, Luciana SantosBarreto, Andréia de Sousa RochaFernandes, Jamille SouzaOliveira, Ricardo RiccioSouza, Robson da Paixão deCarvalho Filho, Edgar Marcelino deAraujo, Maria Ilma Andrade SantosCardoso, Luciana SantosBarreto, Andréia de Sousa RochaFernandes, Jamille SouzaOliveira, Ricardo RiccioSouza, Robson da Paixão deCarvalho Filho, Edgar Marcelino deAraujo, Maria Ilma Andrade Santos2014-09-09T14:48:03Z2014-09-09T14:48:03Z20131740-2522http://repositorio.ufba.br/ri/handle/ri/15885p. 1-8The Th2 immune response in chronic schistosomiasis is associated with the development of periportal fibrosis. However, little is known about the phenotype and activation status of T cells in the process. Objective. To evaluate the profile of T cells in schistosomiasis patients with periportal fibrosis. Methods. It was a cross-sectional study, conducted in the village of Agua Preta, Bahia, Brazil, which included 37 subjects with periportal fibrosis determined by ultrasound. Peripheral blood mononuclear cells were obtained by the Ficcol-hypaque gradient and the frequency of T cells expressing the surface markers CD28, CD69, CD25, and CTLA-4 was determined by flow cytometry. Results. The frequency of CD4+CD28+ T lymphocytes was higher in individuals with moderate to severe fibrosis compared to patients with incipient fibrosis. We did not observe any significant difference in the frequency of CD4+ T cells expressing CD69 among groups of individuals. There was also no significant difference in the frequency of CD8+ T cells expressing CD28 or CD69 among the studied groups. Individuals with moderate to severe fibrosis presented a lower frequency of CD8+ T cells, CD4+CD25high T cells, and CD4+CTLA-4+ T cells when compared to patients without fibrosis or incipient fibrosis. The frequency of CD4+CD25low cells did not differ between groups. Conclusion. The high frequency of activated T cells coinciding with a low frequency of putative Treg cells may account for the development of periportal fibrosis in human schistosomiasis.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-03-20T12:38:56Z No. of bitstreams: 1 10.1155-2013-710647.pdf: 2671872 bytes, checksum: 14dcea6b765e057c30ae25952f57ea63 (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2014-09-09T14:48:03Z (GMT) No. of bitstreams: 1 10.1155-2013-710647.pdf: 2671872 bytes, checksum: 14dcea6b765e057c30ae25952f57ea63 (MD5)Made available in DSpace on 2014-09-09T14:48:03Z (GMT). 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dc.title.pt_BR.fl_str_mv Impaired lymphocyte profile in schistosomiasis patients with periportal fibrosis
dc.title.alternative.pt_BR.fl_str_mv Clinical and Developmental Immunology
title Impaired lymphocyte profile in schistosomiasis patients with periportal fibrosis
spellingShingle Impaired lymphocyte profile in schistosomiasis patients with periportal fibrosis
Cardoso, Luciana Santos
title_short Impaired lymphocyte profile in schistosomiasis patients with periportal fibrosis
title_full Impaired lymphocyte profile in schistosomiasis patients with periportal fibrosis
title_fullStr Impaired lymphocyte profile in schistosomiasis patients with periportal fibrosis
title_full_unstemmed Impaired lymphocyte profile in schistosomiasis patients with periportal fibrosis
title_sort Impaired lymphocyte profile in schistosomiasis patients with periportal fibrosis
author Cardoso, Luciana Santos
author_facet Cardoso, Luciana Santos
Barreto, Andréia de Sousa Rocha
Fernandes, Jamille Souza
Oliveira, Ricardo Riccio
Souza, Robson da Paixão de
Carvalho Filho, Edgar Marcelino de
Araujo, Maria Ilma Andrade Santos
author_role author
author2 Barreto, Andréia de Sousa Rocha
Fernandes, Jamille Souza
Oliveira, Ricardo Riccio
Souza, Robson da Paixão de
Carvalho Filho, Edgar Marcelino de
Araujo, Maria Ilma Andrade Santos
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Cardoso, Luciana Santos
Barreto, Andréia de Sousa Rocha
Fernandes, Jamille Souza
Oliveira, Ricardo Riccio
Souza, Robson da Paixão de
Carvalho Filho, Edgar Marcelino de
Araujo, Maria Ilma Andrade Santos
Cardoso, Luciana Santos
Barreto, Andréia de Sousa Rocha
Fernandes, Jamille Souza
Oliveira, Ricardo Riccio
Souza, Robson da Paixão de
Carvalho Filho, Edgar Marcelino de
Araujo, Maria Ilma Andrade Santos
description p. 1-8
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2014-09-09T14:48:03Z
dc.date.available.fl_str_mv 2014-09-09T14:48:03Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/15885
dc.identifier.issn.none.fl_str_mv 1740-2522
identifier_str_mv 1740-2522
url http://repositorio.ufba.br/ri/handle/ri/15885
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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