Down-Regulation of Th1 Type of Response in Early Human American Cutaneous Leishmaniasis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 1999 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/12453 |
Resumo: | Texto completo. Acesso restrito. p.1731-1734 |
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Rocha, Paulo NovisAlmeida, Roque Pacheco deBacellar, Maria Olívia Amado RamosJesus, Amélia Maria Ribeiro deCorreia Filho, DalmoCruz Filho, Álvaro Augusto Souza daBarral, Aldina Maria PradoCoffman, Robert L.Carvalho Filho, Edgar Marcelino deRocha, Paulo NovisAlmeida, Roque Pacheco deBacellar, Maria Olívia Amado RamosJesus, Amélia Maria Ribeiro deCorreia Filho, DalmoCruz Filho, Álvaro Augusto Souza daBarral, Aldina Maria PradoCoffman, Robert L.Carvalho Filho, Edgar Marcelino de2013-08-05T13:29:47Z19990022-1899http://www.repositorio.ufba.br/ri/handle/ri/12453Texto completo. Acesso restrito. p.1731-1734This study examined the T cell responses in the early phase of Leishmania braziliensis infection. Cytokine profiles, lymphoproliferative responses, and skin test results in 25 patients with early cutaneous leishmaniasis (ECL; illness duration !60 days) were compared with those in persons with late cutaneous leishmaniasis (LCL; illness duration 12 months). Absent or low lymphoproliferative responses were observed in 8 (32%) of 25 patients and an absence of interferon (IFN)–g production in 9 (41%) of 22 patients prior to therapy. IFN-g production in ECL (mean 5 SD) was lower than in LCL (2935346 vs. 7475377 pg/mL, respectively; P ! .01). In contrast, interleukin (IL)–10 production in ECL (mean 5 SD) was higher than in LCL (246556 vs. 50541 pg/mL, respectively;P ! .01) . Restoration of lymphoproliferative responses and IFN-g production was achieved when monoclonal antibody to IL-10 or IL-12 was added to the cultures. These results show that T cell responses during early-phase infection are down-regulated by IL-10 and may facilitate parasite multiplication.Submitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2013-08-01T20:40:16Z No. of bitstreams: 1 777777777777777777777.pdf: 91255 bytes, checksum: 4f795003d50d28945a2af7d42727c258 (MD5)Approved for entry into archive by Flávia Ferreira(flaviaccf@yahoo.com.br) on 2013-08-05T13:29:47Z (GMT) No. of bitstreams: 1 777777777777777777777.pdf: 91255 bytes, checksum: 4f795003d50d28945a2af7d42727c258 (MD5)Made available in DSpace on 2013-08-05T13:29:47Z (GMT). No. of bitstreams: 1 777777777777777777777.pdf: 91255 bytes, checksum: 4f795003d50d28945a2af7d42727c258 (MD5) Previous issue date: 1999SalvadorJournal of Infectious Diseaseshttp://jid.oxfordjournals.org.ez10.periodicos.capes.gov.br/content/180/5/1731.full.pdf+htmlreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBALeishmania braziliensisTh1 CellsInterleukin-10Interleukin-12Down-Regulation of Th1 Type of Response in Early Human American Cutaneous LeishmaniasisJournal of Infectious Diseasesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINAL777777777777777777777.pdf777777777777777777777.pdfapplication/pdf91255https://repositorio.ufba.br/bitstream/ri/12453/1/777777777777777777777.pdf4f795003d50d28945a2af7d42727c258MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/12453/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXT777777777777777777777.pdf.txt777777777777777777777.pdf.txtExtracted texttext/plain16488https://repositorio.ufba.br/bitstream/ri/12453/3/777777777777777777777.pdf.txt5ecb0a1207e6fec1d9657c5d40192a13MD53ri/124532022-07-05 14:03:01.9oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:01Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Down-Regulation of Th1 Type of Response in Early Human American Cutaneous Leishmaniasis |
| dc.title.alternative.pt_BR.fl_str_mv |
Journal of Infectious Diseases |
| title |
Down-Regulation of Th1 Type of Response in Early Human American Cutaneous Leishmaniasis |
| spellingShingle |
Down-Regulation of Th1 Type of Response in Early Human American Cutaneous Leishmaniasis Rocha, Paulo Novis Leishmania braziliensis Th1 Cells Interleukin-10 Interleukin-12 |
| title_short |
Down-Regulation of Th1 Type of Response in Early Human American Cutaneous Leishmaniasis |
| title_full |
Down-Regulation of Th1 Type of Response in Early Human American Cutaneous Leishmaniasis |
| title_fullStr |
Down-Regulation of Th1 Type of Response in Early Human American Cutaneous Leishmaniasis |
| title_full_unstemmed |
Down-Regulation of Th1 Type of Response in Early Human American Cutaneous Leishmaniasis |
| title_sort |
Down-Regulation of Th1 Type of Response in Early Human American Cutaneous Leishmaniasis |
| author |
Rocha, Paulo Novis |
| author_facet |
Rocha, Paulo Novis Almeida, Roque Pacheco de Bacellar, Maria Olívia Amado Ramos Jesus, Amélia Maria Ribeiro de Correia Filho, Dalmo Cruz Filho, Álvaro Augusto Souza da Barral, Aldina Maria Prado Coffman, Robert L. Carvalho Filho, Edgar Marcelino de |
| author_role |
author |
| author2 |
Almeida, Roque Pacheco de Bacellar, Maria Olívia Amado Ramos Jesus, Amélia Maria Ribeiro de Correia Filho, Dalmo Cruz Filho, Álvaro Augusto Souza da Barral, Aldina Maria Prado Coffman, Robert L. Carvalho Filho, Edgar Marcelino de |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Rocha, Paulo Novis Almeida, Roque Pacheco de Bacellar, Maria Olívia Amado Ramos Jesus, Amélia Maria Ribeiro de Correia Filho, Dalmo Cruz Filho, Álvaro Augusto Souza da Barral, Aldina Maria Prado Coffman, Robert L. Carvalho Filho, Edgar Marcelino de Rocha, Paulo Novis Almeida, Roque Pacheco de Bacellar, Maria Olívia Amado Ramos Jesus, Amélia Maria Ribeiro de Correia Filho, Dalmo Cruz Filho, Álvaro Augusto Souza da Barral, Aldina Maria Prado Coffman, Robert L. Carvalho Filho, Edgar Marcelino de |
| dc.subject.por.fl_str_mv |
Leishmania braziliensis Th1 Cells Interleukin-10 Interleukin-12 |
| topic |
Leishmania braziliensis Th1 Cells Interleukin-10 Interleukin-12 |
| description |
Texto completo. Acesso restrito. p.1731-1734 |
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1999 |
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1999 |
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2013-08-05T13:29:47Z |
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Journal of Infectious Diseases |
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Journal of Infectious Diseases |
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