Genomic features and evolutionary constraints in Saffold-like cardioviruses

Detalhes bibliográficos
Autor(a) principal: Drexler, Jan Felix
Data de Publicação: 2010
Outros Autores: Baumgarte, Sigrid, Luna, Luciano Kleber de Souza, Stöcker, Andreas, Almeida, Patrícia Silva, Ribeiro, Tereza Cristina Medrado, Pedroso, Célia, Brites, Carlos, Ribeiro Jr, Hugo da Costa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/13428
Resumo: Texto completo: acesso restrito. p.1418-1427
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spelling Drexler, Jan FelixBaumgarte, SigridLuna, Luciano Kleber de SouzaStöcker, AndreasAlmeida, Patrícia SilvaRibeiro, Tereza Cristina MedradoPedroso, CéliaBrites, CarlosRibeiro Jr, Hugo da CostaDrexler, Jan FelixBaumgarte, SigridLuna, Luciano Kleber de SouzaStöcker, AndreasAlmeida, Patrícia SilvaRibeiro, Tereza Cristina MedradoPedroso, CéliaBrites, CarlosRibeiro Jr, Hugo da Costa2013-10-31T18:07:25Z20100022-1317http://repositorio.ufba.br/ri/handle/ri/13428v. 91, n. 6Texto completo: acesso restrito. p.1418-1427This study identified the complete genomic sequence of four type 2 and type 3 human Saffold-like cardioviruses (SLCVs) isolated in Germany and Brazil. The secondary structures of the SLCV internal ribosome entry sites (IRESs) were deduced based on RNA base-pairing conservation and co-variation, using an established Theiler's murine encephalomyelitis virus (TMEV) IRES structure as a reference. The SLCV IRES was highly similar to that of TMEV, but motifs critical in TMEV for binding of the polypyrimidine tract-binding protein (PTB) were disrupted. In TMEV, corresponding alterations have been associated with reduced neurovirulence in mice. In the non-structural genome region, there was evidence of multiple intertypic recombination events between different SLCV types. Between viruses of the same type, recombination also occurred in the capsid-encoding genome region. There were apparently no recombination events between mouse TMEV and human SLCV. In another genus of the family Picornaviridae, Enterovirus, natural recombination occurs strictly within species and can serve as an additional criterion for delimiting species. Accordingly, the results of this study suggest that SLCV and TMEV may represent distinct species within the genus Cardiovirus.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-08-28T14:52:47Z No. of bitstreams: 1 Jan Drexler1418.full.pdf: 563463 bytes, checksum: 23a2f23905662e9ee3ad6769391d0b2d (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2013-10-31T18:07:25Z (GMT) No. of bitstreams: 1 Jan Drexler1418.full.pdf: 563463 bytes, checksum: 23a2f23905662e9ee3ad6769391d0b2d (MD5)Made available in DSpace on 2013-10-31T18:07:25Z (GMT). No. of bitstreams: 1 Jan Drexler1418.full.pdf: 563463 bytes, checksum: 23a2f23905662e9ee3ad6769391d0b2d (MD5) Previous issue date: 2010http://dx.doi.org/10.1099/vir.0.018887-0reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAGenomic features and evolutionary constraints in Saffold-like cardiovirusesJournal of General Virologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengLICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/13428/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52ORIGINALJan Drexler1418.full.pdfJan Drexler1418.full.pdfapplication/pdf563463https://repositorio.ufba.br/bitstream/ri/13428/1/Jan%20Drexler1418.full.pdf23a2f23905662e9ee3ad6769391d0b2dMD51TEXTJan Drexler1418.full.pdf.txtJan Drexler1418.full.pdf.txtExtracted texttext/plain42939https://repositorio.ufba.br/bitstream/ri/13428/3/Jan%20Drexler1418.full.pdf.txta344e21d50d0b9d252e742e974e82ddfMD53ri/134282022-08-08 13:17:53.178oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-08-08T16:17:53Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Genomic features and evolutionary constraints in Saffold-like cardioviruses
dc.title.alternative.pt_BR.fl_str_mv Journal of General Virology
title Genomic features and evolutionary constraints in Saffold-like cardioviruses
spellingShingle Genomic features and evolutionary constraints in Saffold-like cardioviruses
Drexler, Jan Felix
title_short Genomic features and evolutionary constraints in Saffold-like cardioviruses
title_full Genomic features and evolutionary constraints in Saffold-like cardioviruses
title_fullStr Genomic features and evolutionary constraints in Saffold-like cardioviruses
title_full_unstemmed Genomic features and evolutionary constraints in Saffold-like cardioviruses
title_sort Genomic features and evolutionary constraints in Saffold-like cardioviruses
author Drexler, Jan Felix
author_facet Drexler, Jan Felix
Baumgarte, Sigrid
Luna, Luciano Kleber de Souza
Stöcker, Andreas
Almeida, Patrícia Silva
Ribeiro, Tereza Cristina Medrado
Pedroso, Célia
Brites, Carlos
Ribeiro Jr, Hugo da Costa
author_role author
author2 Baumgarte, Sigrid
Luna, Luciano Kleber de Souza
Stöcker, Andreas
Almeida, Patrícia Silva
Ribeiro, Tereza Cristina Medrado
Pedroso, Célia
Brites, Carlos
Ribeiro Jr, Hugo da Costa
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Drexler, Jan Felix
Baumgarte, Sigrid
Luna, Luciano Kleber de Souza
Stöcker, Andreas
Almeida, Patrícia Silva
Ribeiro, Tereza Cristina Medrado
Pedroso, Célia
Brites, Carlos
Ribeiro Jr, Hugo da Costa
Drexler, Jan Felix
Baumgarte, Sigrid
Luna, Luciano Kleber de Souza
Stöcker, Andreas
Almeida, Patrícia Silva
Ribeiro, Tereza Cristina Medrado
Pedroso, Célia
Brites, Carlos
Ribeiro Jr, Hugo da Costa
description Texto completo: acesso restrito. p.1418-1427
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2013-10-31T18:07:25Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/13428
dc.identifier.issn.none.fl_str_mv 0022-1317
dc.identifier.number.pt_BR.fl_str_mv v. 91, n. 6
identifier_str_mv 0022-1317
v. 91, n. 6
url http://repositorio.ufba.br/ri/handle/ri/13428
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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