Absence of Gamma Interferon and Interleukin 2 Production during Active Visceral Leishmaniasis

Detalhes bibliográficos
Autor(a) principal: Carvalho Filho, Edgar Marcelino de
Data de Publicação: 1985
Outros Autores: Badaró, Roberto José da Silva
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/8599
Resumo: Texto completo. Acesso restrito. p. 2066-2069
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spelling Carvalho Filho, Edgar Marcelino deBadaró, Roberto José da SilvaCarvalho Filho, Edgar Marcelino deBadaró, Roberto José da Silva2013-02-21T13:21:39Z2013-02-21T13:21:39Z1985http://www.repositorio.ufba.br/ri/handle/ri/8599v. 76, n.6Texto completo. Acesso restrito. p. 2066-2069The lymphocytes from eight patients with active visceral leishmaniasis (VL), a disease associated with marked immunologic dysfunction, were examined for ability to produce interleukin 2 (IL-2) and gamma interferon during in vitro cultivation. It was found that both IL-2 and gamma interferon production, in response to leishmania antigen, was absent during the active disease, but was restored after successful chemotherapy. Untreated VL patients produced IL-2 and gamma interferon when stimulated with phytohemagglutinin (PHA). Six patients with either active cutaneous or mucosal leishmaniasis, a disease not associated with immunosuppression, showed high levels of gamma interferon in response to leishmania antigen and PHA. Since IL-2 and gamma interferon have been shown to have important roles in the immune response and in the killing of leishmania, their absence may represent a key defect in the immune response in VL.Submitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2013-02-20T18:42:25Z No. of bitstreams: 1 3333.pdf: 2267084 bytes, checksum: 89c3db9b25d364cd4dd6820e6eb18c07 (MD5)Approved for entry into archive by Fatima Cleômenis Botelho Maria (botelho@ufba.br) on 2013-02-21T13:21:39Z (GMT) No. of bitstreams: 1 3333.pdf: 2267084 bytes, checksum: 89c3db9b25d364cd4dd6820e6eb18c07 (MD5)Made available in DSpace on 2013-02-21T13:21:39Z (GMT). No. of bitstreams: 1 3333.pdf: 2267084 bytes, checksum: 89c3db9b25d364cd4dd6820e6eb18c07 (MD5) Previous issue date: 1985SalvadorJournal of Clinical Investigation10.1172/JCI112209reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAAbsence of Gamma Interferon and Interleukin 2 Production during Active Visceral LeishmaniasisJournal of Clinical Investigationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessORIGINAL3333.pdf3333.pdfapplication/pdf2267084https://repositorio.ufba.br/bitstream/ri/8599/1/3333.pdf89c3db9b25d364cd4dd6820e6eb18c07MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/8599/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXT3333.pdf.txt3333.pdf.txtExtracted texttext/plain4https://repositorio.ufba.br/bitstream/ri/8599/3/3333.pdf.txtff4c8ff01d544500ea4bfea43e6108c1MD53ri/85992022-08-08 13:17:42.43oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-08-08T16:17:42Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Absence of Gamma Interferon and Interleukin 2 Production during Active Visceral Leishmaniasis
dc.title.alternative.pt_BR.fl_str_mv Journal of Clinical Investigation
title Absence of Gamma Interferon and Interleukin 2 Production during Active Visceral Leishmaniasis
spellingShingle Absence of Gamma Interferon and Interleukin 2 Production during Active Visceral Leishmaniasis
Carvalho Filho, Edgar Marcelino de
title_short Absence of Gamma Interferon and Interleukin 2 Production during Active Visceral Leishmaniasis
title_full Absence of Gamma Interferon and Interleukin 2 Production during Active Visceral Leishmaniasis
title_fullStr Absence of Gamma Interferon and Interleukin 2 Production during Active Visceral Leishmaniasis
title_full_unstemmed Absence of Gamma Interferon and Interleukin 2 Production during Active Visceral Leishmaniasis
title_sort Absence of Gamma Interferon and Interleukin 2 Production during Active Visceral Leishmaniasis
author Carvalho Filho, Edgar Marcelino de
author_facet Carvalho Filho, Edgar Marcelino de
Badaró, Roberto José da Silva
author_role author
author2 Badaró, Roberto José da Silva
author2_role author
dc.contributor.author.fl_str_mv Carvalho Filho, Edgar Marcelino de
Badaró, Roberto José da Silva
Carvalho Filho, Edgar Marcelino de
Badaró, Roberto José da Silva
description Texto completo. Acesso restrito. p. 2066-2069
publishDate 1985
dc.date.issued.fl_str_mv 1985
dc.date.accessioned.fl_str_mv 2013-02-21T13:21:39Z
dc.date.available.fl_str_mv 2013-02-21T13:21:39Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/8599
dc.identifier.number.pt_BR.fl_str_mv v. 76, n.6
url http://www.repositorio.ufba.br/ri/handle/ri/8599
identifier_str_mv v. 76, n.6
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Journal of Clinical Investigation
publisher.none.fl_str_mv Journal of Clinical Investigation
dc.source.pt_BR.fl_str_mv 10.1172/JCI112209
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
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reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
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