Molecular biology and clinical implication of hepatitis C virus
Autor(a) principal: | |
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Data de Publicação: | 2004 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFBA |
Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/6965 |
Resumo: | p. 691-695 |
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Lyra, André CastroFan, X.Di Bisceglie, A. M.Lyra, André CastroFan, X.Di Bisceglie, A. M.2012-10-16T20:08:25Z2012-10-16T20:08:25Z20040100-879Xhttp://www.repositorio.ufba.br/ri/handle/ri/6965p. 691-695Hepatitis C virus (HCV) was first described in 1989 as the putative viral agent of non-A non-B hepatitis. It is a member of the Flaviviridae family and has been recognized as the major causative agent of chronic liver disease, including chronic active hepatitis, cirrhosis and hepatocellular carcinoma. HCV is a positive RNA virus with a genome containing approximately 9500 nucleotides. It has an open reading frame that encodes a large polyprotein of about 3000 amino acids and is characterized by extensive genetic diversity. HCV has been classified into at least 6 major genotypes with many subtypes and circulates within an infected individual as a number of closely related but distinct variants known as quasispecies. This article reviews aspects of the molecular biology of HCV and their clinical implication.Submitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2012-10-16T20:08:25Z No. of bitstreams: 1 Lyra, A.C.,.pdf: 499101 bytes, checksum: 305949ea52bf3394fad9887fc2b8c9a7 (MD5)Made available in DSpace on 2012-10-16T20:08:25Z (GMT). No. of bitstreams: 1 Lyra, A.C.,.pdf: 499101 bytes, checksum: 305949ea52bf3394fad9887fc2b8c9a7 (MD5) Previous issue date: 2004SalvadorBrazilian Journal of Medical and Biological ResearchMolecular biology and clinical implication of hepatitis C virusBrazilian Journal of Medical and Biological Researchinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAinfo:eu-repo/semantics/openAccessORIGINALLyra, A.C.,.pdfLyra, A.C.,.pdfapplication/pdf499101https://repositorio.ufba.br/bitstream/ri/6965/1/Lyra%2c%20A.C.%2c.pdf305949ea52bf3394fad9887fc2b8c9a7MD51LICENSElicense.txtlicense.txttext/plain1809https://repositorio.ufba.br/bitstream/ri/6965/2/license.txt8bb3e3eb871f5854a9ec419f68651b60MD52TEXTLyra, A.C.,.pdf.txtLyra, A.C.,.pdf.txtExtracted texttext/plain22618https://repositorio.ufba.br/bitstream/ri/6965/3/Lyra%2c%20A.C.%2c.pdf.txtb1259a4c399cf2b72516060f23a699deMD53ri/69652022-07-05 14:03:07.733oai:repositorio.ufba.br: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ório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:07Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
dc.title.pt_BR.fl_str_mv |
Molecular biology and clinical implication of hepatitis C virus |
dc.title.alternative.pt_BR.fl_str_mv |
Brazilian Journal of Medical and Biological Research |
title |
Molecular biology and clinical implication of hepatitis C virus |
spellingShingle |
Molecular biology and clinical implication of hepatitis C virus Lyra, André Castro |
title_short |
Molecular biology and clinical implication of hepatitis C virus |
title_full |
Molecular biology and clinical implication of hepatitis C virus |
title_fullStr |
Molecular biology and clinical implication of hepatitis C virus |
title_full_unstemmed |
Molecular biology and clinical implication of hepatitis C virus |
title_sort |
Molecular biology and clinical implication of hepatitis C virus |
author |
Lyra, André Castro |
author_facet |
Lyra, André Castro Fan, X. Di Bisceglie, A. M. |
author_role |
author |
author2 |
Fan, X. Di Bisceglie, A. M. |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Lyra, André Castro Fan, X. Di Bisceglie, A. M. Lyra, André Castro Fan, X. Di Bisceglie, A. M. |
description |
p. 691-695 |
publishDate |
2004 |
dc.date.issued.fl_str_mv |
2004 |
dc.date.accessioned.fl_str_mv |
2012-10-16T20:08:25Z |
dc.date.available.fl_str_mv |
2012-10-16T20:08:25Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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0100-879X |
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0100-879X |
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http://www.repositorio.ufba.br/ri/handle/ri/6965 |
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eng |
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eng |
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Brazilian Journal of Medical and Biological Research |
publisher.none.fl_str_mv |
Brazilian Journal of Medical and Biological Research |
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