Oleanolic Acid, a Pentacyclic Triterpene Attenuates the Mustard Oil-Induced Colonic Nociception in Mice
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFBA |
Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/12954 |
Resumo: | Texto completo: acesso restrito.p.82-85 |
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David, Juceni Pereira de LimaDavid, Jorge MauricioLima Júnior, Roberto César PereiraSantos, Flávia AlmeidaMaia, Juliana LemosRao, Vietla SatyanarayanaDavid, Juceni Pereira de LimaDavid, Jorge MauricioLima Júnior, Roberto César PereiraSantos, Flávia AlmeidaMaia, Juliana LemosRao, Vietla Satyanarayana2013-09-16T19:52:55Z20060918-6158http://www.repositorio.ufba.br/ri/handle/ri/12954v.29 n. 1Texto completo: acesso restrito.p.82-85Many natural terpenoid compounds from plants exhibit antinociceptive property but very few studies have addressed their efficacy in visceral models of nociception. The present study evaluated the antinociceptive potential of oleanolic acid, a pentacyclic triterpene in the mouse model of colonic nociception induced by mustard oil. We further examined the possible participation of opioid, α2-adrenergic, and transient receptor potential vanilloid 1 (TRPV1)-receptors in its mechanism. Mice were pretreated orally with oleanolic acid (3, 10, 30 mg/kg) or vehicle, and the pain-related behavioral responses to intracolonic injection of mustard oil was analysed. Oleanolic acid significantly suppressed the mustard oil-induced nociceptive behaviors at test doses of 10 and 30 mg/kg, in a dose-related manner. The antinociceptive effect of oleanolic acid (30 mg/kg) was significantly blocked by pretreatment with the opioid antagonist, naloxone (2 mg/kg, i.p.), while the α2-adrenoceptor antagonist, yohimbine (2 mg/kg, s.c.), had no effect. Pretreatment with ruthenium red (3 mg/kg, s.c.), a non-competitive TRPV1 antagonist alone caused significant inhibition of mustard oil-induced nociception but its co-administration with oleanolic acid produced neither antagonism nor potentiation of oleanolic acid antinociception. In the open-field test that detects sedative or motor abnormality, mice received 30 mg/kg oleanolic acid did not show any per se influence, but significantly inhibited the mustard oil-induced decrease in ambulation frequency. These data demonstrate the visceral antinociceptive potential of oleanolic acid that involves an opioid mechanism and possibly a modulatory influence on vanilloid-receptors, which needs further study.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2013-09-05T15:01:39Z No. of bitstreams: 1 _pdf.pdf: 202301 bytes, checksum: 96cc86d2f165688f542988affee41d78 (MD5)Approved for entry into archive by Alda Lima da Silva(sivalda@ufba.br) on 2013-09-16T19:52:54Z (GMT) No. of bitstreams: 1 _pdf.pdf: 202301 bytes, checksum: 96cc86d2f165688f542988affee41d78 (MD5)Made available in DSpace on 2013-09-16T19:52:55Z (GMT). No. of bitstreams: 1 _pdf.pdf: 202301 bytes, checksum: 96cc86d2f165688f542988affee41d78 (MD5) Previous issue date: 2006http://dx.doi.org/10.1248/bpb.29.82reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAOleanolic acidPentacyclic triterpeneVisceral nociceptionMustard oilAntinociceptive activityOleanolic Acid, a Pentacyclic Triterpene Attenuates the Mustard Oil-Induced Colonic Nociception in MiceBiological and Pharmaceutical Bulletininfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINAL_pdf.pdf_pdf.pdfapplication/pdf202301https://repositorio.ufba.br/bitstream/ri/12954/1/_pdf.pdf96cc86d2f165688f542988affee41d78MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/12954/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52ri/129542022-08-08 13:17:52.245oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-08-08T16:17:52Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
dc.title.pt_BR.fl_str_mv |
Oleanolic Acid, a Pentacyclic Triterpene Attenuates the Mustard Oil-Induced Colonic Nociception in Mice |
dc.title.alternative.pt_BR.fl_str_mv |
Biological and Pharmaceutical Bulletin |
title |
Oleanolic Acid, a Pentacyclic Triterpene Attenuates the Mustard Oil-Induced Colonic Nociception in Mice |
spellingShingle |
Oleanolic Acid, a Pentacyclic Triterpene Attenuates the Mustard Oil-Induced Colonic Nociception in Mice David, Juceni Pereira de Lima Oleanolic acid Pentacyclic triterpene Visceral nociception Mustard oil Antinociceptive activity |
title_short |
Oleanolic Acid, a Pentacyclic Triterpene Attenuates the Mustard Oil-Induced Colonic Nociception in Mice |
title_full |
Oleanolic Acid, a Pentacyclic Triterpene Attenuates the Mustard Oil-Induced Colonic Nociception in Mice |
title_fullStr |
Oleanolic Acid, a Pentacyclic Triterpene Attenuates the Mustard Oil-Induced Colonic Nociception in Mice |
title_full_unstemmed |
Oleanolic Acid, a Pentacyclic Triterpene Attenuates the Mustard Oil-Induced Colonic Nociception in Mice |
title_sort |
Oleanolic Acid, a Pentacyclic Triterpene Attenuates the Mustard Oil-Induced Colonic Nociception in Mice |
author |
David, Juceni Pereira de Lima |
author_facet |
David, Juceni Pereira de Lima David, Jorge Mauricio Lima Júnior, Roberto César Pereira Santos, Flávia Almeida Maia, Juliana Lemos Rao, Vietla Satyanarayana |
author_role |
author |
author2 |
David, Jorge Mauricio Lima Júnior, Roberto César Pereira Santos, Flávia Almeida Maia, Juliana Lemos Rao, Vietla Satyanarayana |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
David, Juceni Pereira de Lima David, Jorge Mauricio Lima Júnior, Roberto César Pereira Santos, Flávia Almeida Maia, Juliana Lemos Rao, Vietla Satyanarayana David, Juceni Pereira de Lima David, Jorge Mauricio Lima Júnior, Roberto César Pereira Santos, Flávia Almeida Maia, Juliana Lemos Rao, Vietla Satyanarayana |
dc.subject.por.fl_str_mv |
Oleanolic acid Pentacyclic triterpene Visceral nociception Mustard oil Antinociceptive activity |
topic |
Oleanolic acid Pentacyclic triterpene Visceral nociception Mustard oil Antinociceptive activity |
description |
Texto completo: acesso restrito.p.82-85 |
publishDate |
2006 |
dc.date.issued.fl_str_mv |
2006 |
dc.date.accessioned.fl_str_mv |
2013-09-16T19:52:55Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.repositorio.ufba.br/ri/handle/ri/12954 |
dc.identifier.issn.none.fl_str_mv |
0918-6158 |
dc.identifier.number.pt_BR.fl_str_mv |
v.29 n. 1 |
identifier_str_mv |
0918-6158 v.29 n. 1 |
url |
http://www.repositorio.ufba.br/ri/handle/ri/12954 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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http://dx.doi.org/10.1248/bpb.29.82 |
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