Oleanolic acid, a pentacyclic triterpene attenuates capsaicin-induced nociception in mice: Possible mechanisms
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2006 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/6391 |
Resumo: | RESTRITO |
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Maia, Juliana LemosLima Júnior, Roberto César PereiraMelo, Caroline MourãoDavid, Juceni Pereira de LimaDavid, Jorge MauricioCampos, Adriana RolimSantos, Flávia AlmeidaRao, Vietla SatyanarayanaMaia, Juliana LemosLima Júnior, Roberto César PereiraMelo, Caroline MourãoDavid, Juceni Pereira de LimaDavid, Jorge MauricioCampos, Adriana RolimSantos, Flávia AlmeidaRao, Vietla Satyanarayana2012-07-10T14:48:21Z2012-07-10T14:48:21Z20061043-6618http://www.repositorio.ufba.br/ri/handle/ri/6391v.54, n.4RESTRITOThe anti-inflammatory pentacyclic triterpene, oleanolic acid (OA) was examined on acute nociception induced by intraplantar injection of capsaicin in mice. OA administered orally to mice at 10, 30 and 100 mg kg−1, significantly attenuated the paw-licking response to capsaicin (1.6 μg/paw) by 53%, 68.5% and 36.6%, respectively. Ruthenium red (3 mg kg−1, s.c.), a non-competitive vanilloid receptor (V1, TRPV1)-antagonist also suppressed the capsaicin nociception by 38.6%. The maximal antinociception produced by 30 mg kg−1 OA was significantly blocked in animals pre-treated with naloxone (2 mg kg−1, i.p.), the opioid antagonist; l-arginine (600 mg kg−1, i.p.), the substrate for nitric oxide synthase; or glibenclamide (2 mg kg−1, i.p.), the KATP-channel blocker, but was unaffected by yohimbine (2 mg kg−1, i.p.), an α2-adrenoceptor antagonist. In open-field and rota-rod tests that detect motor deficits, mice received 30 mg kg−1 OA did not manifest any effect per se, indicating that the observed antinociception is not a consequence of motor abnormality. These data suggest that OA inhibits capsaicin-evoked acute nociception due to mechanisms possibly involving endogenous opioids, nitric oxide, and KATP-channel opening.Submitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2012-07-10T14:48:21Z No. of bitstreams: 1 DD.pdf: 191921 bytes, checksum: e7e0d97358e281aeda5710f62c757522 (MD5)Made available in DSpace on 2012-07-10T14:48:21Z (GMT). No. of bitstreams: 1 DD.pdf: 191921 bytes, checksum: e7e0d97358e281aeda5710f62c757522 (MD5) Previous issue date: 2006Pharmacological Researchhttp://dx.doi.org/10.1016/j.phrs.2006.06.003reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAOleanolic acidPentacyclic triterpeneCapsaicinAntinociceptive activityEndogenous opioidsNitric oxideKATP-channelsOleanolic acid, a pentacyclic triterpene attenuates capsaicin-induced nociception in mice: Possible mechanismsPharmacological Researchinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessLICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/6391/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52ORIGINALDD.pdfDD.pdfapplication/pdf191921https://repositorio.ufba.br/bitstream/ri/6391/1/DD.pdfe7e0d97358e281aeda5710f62c757522MD51TEXTDD.pdf.txtDD.pdf.txtExtracted texttext/plain25781https://repositorio.ufba.br/bitstream/ri/6391/3/DD.pdf.txt4627939bf93c7073dcece1babe3a5f09MD53ri/63912022-07-05 14:03:17.116oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:17Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Oleanolic acid, a pentacyclic triterpene attenuates capsaicin-induced nociception in mice: Possible mechanisms |
| dc.title.alternative.pt_BR.fl_str_mv |
Pharmacological Research |
| title |
Oleanolic acid, a pentacyclic triterpene attenuates capsaicin-induced nociception in mice: Possible mechanisms |
| spellingShingle |
Oleanolic acid, a pentacyclic triterpene attenuates capsaicin-induced nociception in mice: Possible mechanisms Maia, Juliana Lemos Oleanolic acid Pentacyclic triterpene Capsaicin Antinociceptive activity Endogenous opioids Nitric oxide KATP-channels |
| title_short |
Oleanolic acid, a pentacyclic triterpene attenuates capsaicin-induced nociception in mice: Possible mechanisms |
| title_full |
Oleanolic acid, a pentacyclic triterpene attenuates capsaicin-induced nociception in mice: Possible mechanisms |
| title_fullStr |
Oleanolic acid, a pentacyclic triterpene attenuates capsaicin-induced nociception in mice: Possible mechanisms |
| title_full_unstemmed |
Oleanolic acid, a pentacyclic triterpene attenuates capsaicin-induced nociception in mice: Possible mechanisms |
| title_sort |
Oleanolic acid, a pentacyclic triterpene attenuates capsaicin-induced nociception in mice: Possible mechanisms |
| author |
Maia, Juliana Lemos |
| author_facet |
Maia, Juliana Lemos Lima Júnior, Roberto César Pereira Melo, Caroline Mourão David, Juceni Pereira de Lima David, Jorge Mauricio Campos, Adriana Rolim Santos, Flávia Almeida Rao, Vietla Satyanarayana |
| author_role |
author |
| author2 |
Lima Júnior, Roberto César Pereira Melo, Caroline Mourão David, Juceni Pereira de Lima David, Jorge Mauricio Campos, Adriana Rolim Santos, Flávia Almeida Rao, Vietla Satyanarayana |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Maia, Juliana Lemos Lima Júnior, Roberto César Pereira Melo, Caroline Mourão David, Juceni Pereira de Lima David, Jorge Mauricio Campos, Adriana Rolim Santos, Flávia Almeida Rao, Vietla Satyanarayana Maia, Juliana Lemos Lima Júnior, Roberto César Pereira Melo, Caroline Mourão David, Juceni Pereira de Lima David, Jorge Mauricio Campos, Adriana Rolim Santos, Flávia Almeida Rao, Vietla Satyanarayana |
| dc.subject.por.fl_str_mv |
Oleanolic acid Pentacyclic triterpene Capsaicin Antinociceptive activity Endogenous opioids Nitric oxide KATP-channels |
| topic |
Oleanolic acid Pentacyclic triterpene Capsaicin Antinociceptive activity Endogenous opioids Nitric oxide KATP-channels |
| description |
RESTRITO |
| publishDate |
2006 |
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2006 |
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2012-07-10T14:48:21Z |
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2012-07-10T14:48:21Z |
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info:eu-repo/semantics/publishedVersion |
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1043-6618 |
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v.54, n.4 |
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1043-6618 v.54, n.4 |
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http://www.repositorio.ufba.br/ri/handle/ri/6391 |
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Pharmacological Research |
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Pharmacological Research |
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http://dx.doi.org/10.1016/j.phrs.2006.06.003 |
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