Evidence for the Involvement of Descending Pain-Inhibitory Mechanisms in the Antinociceptive Effect of Hecogenin Acetate

Detalhes bibliográficos
Autor(a) principal: Gama, Kelly Barbosa
Data de Publicação: 2013
Outros Autores: Quintans, Jullyana de Souza Siqueira, Antoniolli, Ângelo Roberto, Quintans Júnior, Lucindo José, Santana, Wagno Alcântara de, Branco, Alexsandro, Soares, Milena Botelho Pereira, Villarreal, Cristiane Flora
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/16689
Resumo: Texto completo: acesso restrito. p. 559−563
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spelling Gama, Kelly BarbosaQuintans, Jullyana de Souza SiqueiraAntoniolli, Ângelo RobertoQuintans Júnior, Lucindo JoséSantana, Wagno Alcântara deBranco, AlexsandroSoares, Milena Botelho PereiraVillarreal, Cristiane FloraGama, Kelly BarbosaQuintans, Jullyana de Souza SiqueiraAntoniolli, Ângelo RobertoQuintans Júnior, Lucindo JoséSantana, Wagno Alcântara deBranco, AlexsandroSoares, Milena Botelho PereiraVillarreal, Cristiane Flora2014-12-01T20:40:03Z20130163-3864http://repositorio.ufba.br/ri/handle/ri/16689v. 76, n. 4Texto completo: acesso restrito. p. 559−563Hecogenin is a sapogenin present in the leaves of species from the Agave genus, with a wide spectrum of reported pharmacological activities. The present study was undertaken to evaluate whether hecogenin acetate (1) has antinociceptive properties and to determine its mechanism of action. The nociceptive threshold was evaluated using the tail flick test in mice. Mice motor performance was evaluated in a Rotarod test. By using Fos expression as a marker of neural activation, the involvement of the periaqueductal gray in 1-induced antinociception was evaluated. Intraperitoneal administration of 1 (5–40 mg/kg) produced a dose-dependent increase in the tail flick latency time compared to vehicle-treated group (p < 0.01). Mice treated with 1 (40 mg/kg) did not show motor performance alterations. The antinociception of 1 (40 mg/kg) was prevented by naloxone (nonselective opioid receptor antagonist; 5 mg/kg), CTOP (μ-opioid receptor antagonist; 1 mg/kg), nor-BNI (κ-opioid receptor antagonist; 0.5 mg/kg), naltrindole (δ-opioid receptor antagonist; 3 mg/kg), or glibenclamide (ATP-sensitive K+ channel blocker; 2 mg/kg). Systemic administration of 1 (5–40 mg/kg) increased the number of Fos positive cells in the periaqueductal gray. The present study has demonstrated for the first time that 1 produces consistent antinociception mediated by opioid receptors and endogenous analgesic mechanisms.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-11-25T14:30:51Z No. of bitstreams: 1 Kelly Barbosa Gama.pdf: 623352 bytes, checksum: 775057950bf26281a03c9d6374ade542 (MD5)Approved for entry into archive by Patricia Barroso (pbarroso@ufba.br) on 2014-12-01T20:40:03Z (GMT) No. of bitstreams: 1 Kelly Barbosa Gama.pdf: 623352 bytes, checksum: 775057950bf26281a03c9d6374ade542 (MD5)Made available in DSpace on 2014-12-01T20:40:03Z (GMT). No. of bitstreams: 1 Kelly Barbosa Gama.pdf: 623352 bytes, checksum: 775057950bf26281a03c9d6374ade542 (MD5) Previous issue date: 2013http://dx.doi.org/ 10.1021/np3007342reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAEvidence for the Involvement of Descending Pain-Inhibitory Mechanisms in the Antinociceptive Effect of Hecogenin AcetateJournal of Natural Productsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINALKelly Barbosa Gama.pdfKelly Barbosa Gama.pdfapplication/pdf623352https://repositorio.ufba.br/bitstream/ri/16689/1/Kelly%20Barbosa%20Gama.pdf775057950bf26281a03c9d6374ade542MD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/16689/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXTKelly Barbosa Gama.pdf.txtKelly Barbosa Gama.pdf.txtExtracted texttext/plain26967https://repositorio.ufba.br/bitstream/ri/16689/3/Kelly%20Barbosa%20Gama.pdf.txt4309dccc13a6cbb97ba954b209f138ffMD53ri/166892022-07-05 14:03:31.269oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:31Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Evidence for the Involvement of Descending Pain-Inhibitory Mechanisms in the Antinociceptive Effect of Hecogenin Acetate
dc.title.alternative.pt_BR.fl_str_mv Journal of Natural Products
title Evidence for the Involvement of Descending Pain-Inhibitory Mechanisms in the Antinociceptive Effect of Hecogenin Acetate
spellingShingle Evidence for the Involvement of Descending Pain-Inhibitory Mechanisms in the Antinociceptive Effect of Hecogenin Acetate
Gama, Kelly Barbosa
title_short Evidence for the Involvement of Descending Pain-Inhibitory Mechanisms in the Antinociceptive Effect of Hecogenin Acetate
title_full Evidence for the Involvement of Descending Pain-Inhibitory Mechanisms in the Antinociceptive Effect of Hecogenin Acetate
title_fullStr Evidence for the Involvement of Descending Pain-Inhibitory Mechanisms in the Antinociceptive Effect of Hecogenin Acetate
title_full_unstemmed Evidence for the Involvement of Descending Pain-Inhibitory Mechanisms in the Antinociceptive Effect of Hecogenin Acetate
title_sort Evidence for the Involvement of Descending Pain-Inhibitory Mechanisms in the Antinociceptive Effect of Hecogenin Acetate
author Gama, Kelly Barbosa
author_facet Gama, Kelly Barbosa
Quintans, Jullyana de Souza Siqueira
Antoniolli, Ângelo Roberto
Quintans Júnior, Lucindo José
Santana, Wagno Alcântara de
Branco, Alexsandro
Soares, Milena Botelho Pereira
Villarreal, Cristiane Flora
author_role author
author2 Quintans, Jullyana de Souza Siqueira
Antoniolli, Ângelo Roberto
Quintans Júnior, Lucindo José
Santana, Wagno Alcântara de
Branco, Alexsandro
Soares, Milena Botelho Pereira
Villarreal, Cristiane Flora
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gama, Kelly Barbosa
Quintans, Jullyana de Souza Siqueira
Antoniolli, Ângelo Roberto
Quintans Júnior, Lucindo José
Santana, Wagno Alcântara de
Branco, Alexsandro
Soares, Milena Botelho Pereira
Villarreal, Cristiane Flora
Gama, Kelly Barbosa
Quintans, Jullyana de Souza Siqueira
Antoniolli, Ângelo Roberto
Quintans Júnior, Lucindo José
Santana, Wagno Alcântara de
Branco, Alexsandro
Soares, Milena Botelho Pereira
Villarreal, Cristiane Flora
description Texto completo: acesso restrito. p. 559−563
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2014-12-01T20:40:03Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/16689
dc.identifier.issn.none.fl_str_mv 0163-3864
dc.identifier.number.pt_BR.fl_str_mv v. 76, n. 4
identifier_str_mv 0163-3864
v. 76, n. 4
url http://repositorio.ufba.br/ri/handle/ri/16689
dc.language.iso.fl_str_mv eng
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.source.pt_BR.fl_str_mv http://dx.doi.org/ 10.1021/np3007342
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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