Immunoregulatory and effector activities in human cutaneous and mucosal Leishmaniasis: Understanding mechanisms of pathology

Detalhes bibliográficos
Autor(a) principal: Dutra, Walderez Ornelas
Data de Publicação: 2011
Outros Autores: Faria, Daniela Rodrigues de, Machado, Paulo Roberto Lima, Guimarães, Luiz Henrique, Schriefer, Nicolaus Albert Borges, Carvalho Filho, Edgar Marcelino de, Gollob, Kenneth John
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/16510
Resumo: Texto completo: acesso restrito. p. 430–436
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spelling Dutra, Walderez OrnelasFaria, Daniela Rodrigues deMachado, Paulo Roberto LimaGuimarães, Luiz HenriqueSchriefer, Nicolaus Albert BorgesCarvalho Filho, Edgar Marcelino deGollob, Kenneth JohnDutra, Walderez OrnelasFaria, Daniela Rodrigues deMachado, Paulo Roberto LimaGuimarães, Luiz HenriqueSchriefer, Nicolaus Albert BorgesCarvalho Filho, Edgar Marcelino deGollob, Kenneth John2014-11-04T15:21:01Z20110272-4391http://repositorio.ufba.br/ri/handle/ri/16510v. 72, n. 6Texto completo: acesso restrito. p. 430–436Individuals infected with Leishmania braziliensis may develop the relatively benign localized cutaneous (CL) form or the mucosal (ML) form of the disease, which represents a more severe and mutilating variation. Interaction between parasite and host cells, as well as the genetic background of the host, are important determinants of the immune response, which is critical in determining disease outcome. Our studies over the years have been designed to determine the immunoregulatory and effector functions that culminate in the formation of lesions in CL and ML disease and how these host response factors may be better understood for design of novel therapies and prophylaxis. By studying the immune response from CL and ML patients in both the peripheral blood and in situ, we have learned much concerning the dynamics of the host–pathogen interaction that leads to the development of CL and ML. We used multiparameter flow cytometry to study the immunoregulatory profiles of the peripheral blood leukocytes, as well as laser scanning confocal microscopy to examine in situ several aspects of the local response, including the intensity of the inflammatory infiltrate, the cellular composition, inflammatory and anti-inflammatory cytokine expression, and the expression of the effector cytotoxic molecule, granzyme A, in lesions from CL and ML patients. Moreover, the application of correlative analysis between these immunological parameters has helped shed light on disease progression in CL and ML. These findings are reviewed within the context of understanding cellular and molecular mechanisms associated with the development of pathology in these diseases through a comparative analysis of the clinical forms, CL and ML, as well as of studies derived from peripheral blood and lesions. Drug Dev Res 72:430–436, 2011. © 2011 Wiley-Liss, Inc.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-04-15T13:32:05Z No. of bitstreams: 1 Walderez O. Dutra.pdf: 210259 bytes, checksum: 6b92f994917e2a0c10b483f278aeb54a (MD5)Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2014-11-04T15:21:01Z (GMT) No. of bitstreams: 1 Walderez O. Dutra.pdf: 210259 bytes, checksum: 6b92f994917e2a0c10b483f278aeb54a (MD5)Made available in DSpace on 2014-11-04T15:21:01Z (GMT). No. of bitstreams: 1 Walderez O. Dutra.pdf: 210259 bytes, checksum: 6b92f994917e2a0c10b483f278aeb54a (MD5) Previous issue date: 2011http://dx.doi.org/ 10.1002/ddr.20449reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBALeishmaniasisImmunoregulationPathologyHumanImmunoregulatory and effector activities in human cutaneous and mucosal Leishmaniasis: Understanding mechanisms of pathologyDrug Development Researchinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINALWalderez O. Dutra.pdfWalderez O. Dutra.pdfapplication/pdf210259https://repositorio.ufba.br/bitstream/ri/16510/1/Walderez%20O.%20Dutra.pdf6b92f994917e2a0c10b483f278aeb54aMD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/16510/2/license.txt0d4b811ef71182510d2015daa7c8a900MD52TEXTWalderez O. Dutra.pdf.txtWalderez O. 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dc.title.pt_BR.fl_str_mv Immunoregulatory and effector activities in human cutaneous and mucosal Leishmaniasis: Understanding mechanisms of pathology
dc.title.alternative.pt_BR.fl_str_mv Drug Development Research
title Immunoregulatory and effector activities in human cutaneous and mucosal Leishmaniasis: Understanding mechanisms of pathology
spellingShingle Immunoregulatory and effector activities in human cutaneous and mucosal Leishmaniasis: Understanding mechanisms of pathology
Dutra, Walderez Ornelas
Leishmaniasis
Immunoregulation
Pathology
Human
title_short Immunoregulatory and effector activities in human cutaneous and mucosal Leishmaniasis: Understanding mechanisms of pathology
title_full Immunoregulatory and effector activities in human cutaneous and mucosal Leishmaniasis: Understanding mechanisms of pathology
title_fullStr Immunoregulatory and effector activities in human cutaneous and mucosal Leishmaniasis: Understanding mechanisms of pathology
title_full_unstemmed Immunoregulatory and effector activities in human cutaneous and mucosal Leishmaniasis: Understanding mechanisms of pathology
title_sort Immunoregulatory and effector activities in human cutaneous and mucosal Leishmaniasis: Understanding mechanisms of pathology
author Dutra, Walderez Ornelas
author_facet Dutra, Walderez Ornelas
Faria, Daniela Rodrigues de
Machado, Paulo Roberto Lima
Guimarães, Luiz Henrique
Schriefer, Nicolaus Albert Borges
Carvalho Filho, Edgar Marcelino de
Gollob, Kenneth John
author_role author
author2 Faria, Daniela Rodrigues de
Machado, Paulo Roberto Lima
Guimarães, Luiz Henrique
Schriefer, Nicolaus Albert Borges
Carvalho Filho, Edgar Marcelino de
Gollob, Kenneth John
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Dutra, Walderez Ornelas
Faria, Daniela Rodrigues de
Machado, Paulo Roberto Lima
Guimarães, Luiz Henrique
Schriefer, Nicolaus Albert Borges
Carvalho Filho, Edgar Marcelino de
Gollob, Kenneth John
Dutra, Walderez Ornelas
Faria, Daniela Rodrigues de
Machado, Paulo Roberto Lima
Guimarães, Luiz Henrique
Schriefer, Nicolaus Albert Borges
Carvalho Filho, Edgar Marcelino de
Gollob, Kenneth John
dc.subject.por.fl_str_mv Leishmaniasis
Immunoregulation
Pathology
Human
topic Leishmaniasis
Immunoregulation
Pathology
Human
description Texto completo: acesso restrito. p. 430–436
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2014-11-04T15:21:01Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/16510
dc.identifier.issn.none.fl_str_mv 0272-4391
dc.identifier.number.pt_BR.fl_str_mv v. 72, n. 6
identifier_str_mv 0272-4391
v. 72, n. 6
url http://repositorio.ufba.br/ri/handle/ri/16510
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/ 10.1002/ddr.20449
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
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instacron_str UFBA
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collection Repositório Institucional da UFBA
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