Identification of paramyosin T cell epitopes associated with human resistance to Schistosoma mansoni reinfection
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2005 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/13769 |
Resumo: | Texto completo: acesso restrito. p. 539–547 |
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Jesus, A. R. deCarvalho Filho, Edgar Marcelino deFonseca, C. T.Cunha-Neto, E.Goldberg, A. C.Kalil, J.Oliveira, R. CorreaHammer, J.Sidney, J.Sette, A.Oliveira, S. C.Jesus, A. R. deCarvalho Filho, Edgar Marcelino deFonseca, C. T.Cunha-Neto, E.Goldberg, A. C.Kalil, J.Oliveira, R. CorreaHammer, J.Sidney, J.Sette, A.Oliveira, S. C.2013-11-19T20:18:55Z20050009-9104http://repositorio.ufba.br/ri/handle/ri/13769v. 142, n. 3Texto completo: acesso restrito. p. 539–547Paramyosin, a Schistosoma mansoni myoprotein associated with human resistance to infection and reinfection, is a candidate antigen to compose a subunit vaccine against schistosomiasis. In this study, 11 paramyosin peptides selected by TEPITOPE algorithm as promiscuous epitopes were produced synthetically and tested in proliferation and in vitro human leucocyte antigen (HLA)-DR binding assays. A differential proliferative response was observed in individuals resistant to reinfection compared to individuals susceptible to reinfection in response to Para (210–226) peptide stimulation. In addition, this peptide was able to bind to all HLA-DR molecules tested in HLA-DR binding assays, confirming its promiscuity. Para (6–22) and Para (355–371) were also shown to be promiscuous peptides, because they were able to bind to the six and eight most prevalent HLA-DR alleles used in HLA-DR binding assays, respectively, and were also recognized by T cells of the individuals studied. These results suggest that these paramyosin peptides are promising antigens to compose an anti-schistosomiasis vaccine.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2013-09-10T16:23:09Z No. of bitstreams: 1 j.1365-2249.2005.02941.x.pdf: 178941 bytes, checksum: 7ddd2822fa30188b563dc6e4aaff8ba6 (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2013-11-19T20:18:55Z (GMT) No. of bitstreams: 1 j.1365-2249.2005.02941.x.pdf: 178941 bytes, checksum: 7ddd2822fa30188b563dc6e4aaff8ba6 (MD5)Made available in DSpace on 2013-11-19T20:18:55Z (GMT). No. of bitstreams: 1 j.1365-2249.2005.02941.x.pdf: 178941 bytes, checksum: 7ddd2822fa30188b563dc6e4aaff8ba6 (MD5) Previous issue date: 2005http://dx.doi.org/10.1111/j.1365-2249.2005.02941.xreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAParamyosinSchistosoma mansoniSynthetic peptidesT cellsVaccineIdentification of paramyosin T cell epitopes associated with human resistance to Schistosoma mansoni reinfectionClinical and Experimental Immunologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINALj.1365-2249.2005.02941.x.pdfj.1365-2249.2005.02941.x.pdfapplication/pdf178941https://repositorio.ufba.br/bitstream/ri/13769/1/j.1365-2249.2005.02941.x.pdf7ddd2822fa30188b563dc6e4aaff8ba6MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/13769/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTj.1365-2249.2005.02941.x.pdf.txtj.1365-2249.2005.02941.x.pdf.txtExtracted texttext/plain41587https://repositorio.ufba.br/bitstream/ri/13769/3/j.1365-2249.2005.02941.x.pdf.txtd131e976cee17d9632bd8f7ce274886bMD53ri/137692022-07-05 14:03:22.514oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:22Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Identification of paramyosin T cell epitopes associated with human resistance to Schistosoma mansoni reinfection |
| dc.title.alternative.pt_BR.fl_str_mv |
Clinical and Experimental Immunology |
| title |
Identification of paramyosin T cell epitopes associated with human resistance to Schistosoma mansoni reinfection |
| spellingShingle |
Identification of paramyosin T cell epitopes associated with human resistance to Schistosoma mansoni reinfection Jesus, A. R. de Paramyosin Schistosoma mansoni Synthetic peptides T cells Vaccine |
| title_short |
Identification of paramyosin T cell epitopes associated with human resistance to Schistosoma mansoni reinfection |
| title_full |
Identification of paramyosin T cell epitopes associated with human resistance to Schistosoma mansoni reinfection |
| title_fullStr |
Identification of paramyosin T cell epitopes associated with human resistance to Schistosoma mansoni reinfection |
| title_full_unstemmed |
Identification of paramyosin T cell epitopes associated with human resistance to Schistosoma mansoni reinfection |
| title_sort |
Identification of paramyosin T cell epitopes associated with human resistance to Schistosoma mansoni reinfection |
| author |
Jesus, A. R. de |
| author_facet |
Jesus, A. R. de Carvalho Filho, Edgar Marcelino de Fonseca, C. T. Cunha-Neto, E. Goldberg, A. C. Kalil, J. Oliveira, R. Correa Hammer, J. Sidney, J. Sette, A. Oliveira, S. C. |
| author_role |
author |
| author2 |
Carvalho Filho, Edgar Marcelino de Fonseca, C. T. Cunha-Neto, E. Goldberg, A. C. Kalil, J. Oliveira, R. Correa Hammer, J. Sidney, J. Sette, A. Oliveira, S. C. |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Jesus, A. R. de Carvalho Filho, Edgar Marcelino de Fonseca, C. T. Cunha-Neto, E. Goldberg, A. C. Kalil, J. Oliveira, R. Correa Hammer, J. Sidney, J. Sette, A. Oliveira, S. C. Jesus, A. R. de Carvalho Filho, Edgar Marcelino de Fonseca, C. T. Cunha-Neto, E. Goldberg, A. C. Kalil, J. Oliveira, R. Correa Hammer, J. Sidney, J. Sette, A. Oliveira, S. C. |
| dc.subject.por.fl_str_mv |
Paramyosin Schistosoma mansoni Synthetic peptides T cells Vaccine |
| topic |
Paramyosin Schistosoma mansoni Synthetic peptides T cells Vaccine |
| description |
Texto completo: acesso restrito. p. 539–547 |
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2005 |
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2005 |
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2013-11-19T20:18:55Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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0009-9104 |
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v. 142, n. 3 |
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0009-9104 v. 142, n. 3 |
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