Neutrophils and macrophages cooperate in host resistance against Leishmania braziliensis infection

Detalhes bibliográficos
Autor(a) principal: Novais, Fernanda Oliveira
Data de Publicação: 2009
Outros Autores: Santiago, Rômulo Carvalho, Báfica, Andre Luiz Barbosa, Cunha, Antônio Ricardo Khouri, Macêdo, Lilian Maria Afonso de, Borges, Valéria de Matos, Brodskyn, Claudia Ida, Barral-Netto, Manoel, Barral, Aldina Maria Prado, Oliveira, Camila Indiani de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/13414
Resumo: Texto completo: acesso restrito. p.8088-8098
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spelling Novais, Fernanda OliveiraSantiago, Rômulo CarvalhoBáfica, Andre Luiz BarbosaCunha, Antônio Ricardo KhouriMacêdo, Lilian Maria Afonso deBorges, Valéria de MatosBrodskyn, Claudia IdaBarral-Netto, ManoelBarral, Aldina Maria PradoOliveira, Camila Indiani deNovais, Fernanda OliveiraSantiago, Rômulo CarvalhoBáfica, Andre Luiz BarbosaCunha, Antônio Ricardo KhouriMacêdo, Lilian Maria Afonso deBorges, Valéria de MatosBrodskyn, Claudia IdaBarral-Netto, ManoelBarral, Aldina Maria PradoOliveira, Camila Indiani de2013-10-31T17:54:26Z20090022-1767http://repositorio.ufba.br/ri/handle/ri/13414v. 183, n. 12Texto completo: acesso restrito. p.8088-8098Neutrophils play an active role in the control of infections caused by intracellular pathogens such as Leishmania. In the present study, we investigated the effect of neutrophil depletion at the time of Leishmania braziliensis infection of BALB/c mice and how neutrophils interact with the infected macrophage to promote parasite elimination. The in vivo depletion of neutrophils led to a significant increase in parasite load and enhanced the Th1-Th2 immune response in this experimental model of infection. BALB/c mice coinoculated with both parasites and live neutrophils displayed lower parasite burdens at the site of infection and in the draining lymph nodes. In vitro, we observed that live neutrophils significantly reduced the parasite load in L. braziliensis-infected murine macrophages, an effect not observed with Leishmania major. L. braziliensis elimination was dependent on the interaction between neutrophils and macrophages and was associated with TNF-α as well as superoxide production. Furthermore, cooperation between neutrophils and macrophages toward parasite elimination was also observed in experiments performed with L. braziliensis-infected human cells and, importantly, with two other New World Leishmania species. These results indicate that neutrophils play an important and previously unappreciated role in L. braziliensis infection, favoring the induction of a protective immune response.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-09-16T16:16:17Z No. of bitstreams: 1 J Immunol-2009-Novais-8088-98.pdf: 4272024 bytes, checksum: ea82b5ff2e0368a5155205a766c86ffb (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2013-10-31T17:54:26Z (GMT) No. of bitstreams: 1 J Immunol-2009-Novais-8088-98.pdf: 4272024 bytes, checksum: ea82b5ff2e0368a5155205a766c86ffb (MD5)Made available in DSpace on 2013-10-31T17:54:26Z (GMT). No. of bitstreams: 1 J Immunol-2009-Novais-8088-98.pdf: 4272024 bytes, checksum: ea82b5ff2e0368a5155205a766c86ffb (MD5) Previous issue date: 2010http://dx.doi.org/10.4049/​jimmunol.0803720reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBANeutrophils and macrophages cooperate in host resistance against Leishmania braziliensis infectionJournal of Immunologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengLICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/13414/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52ORIGINALJ Immunol-2009-Novais-8088-98.pdfJ Immunol-2009-Novais-8088-98.pdfapplication/pdf4272024https://repositorio.ufba.br/bitstream/ri/13414/1/J%20Immunol-2009-Novais-8088-98.pdfea82b5ff2e0368a5155205a766c86ffbMD51TEXTJ Immunol-2009-Novais-8088-98.pdf.txtJ Immunol-2009-Novais-8088-98.pdf.txtExtracted texttext/plain64275https://repositorio.ufba.br/bitstream/ri/13414/3/J%20Immunol-2009-Novais-8088-98.pdf.txt918b0a2e863a19f8f9a143eb071138c0MD53ri/134142022-10-24 21:40:02.777oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-10-25T00:40:02Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Neutrophils and macrophages cooperate in host resistance against Leishmania braziliensis infection
dc.title.alternative.pt_BR.fl_str_mv Journal of Immunology
title Neutrophils and macrophages cooperate in host resistance against Leishmania braziliensis infection
spellingShingle Neutrophils and macrophages cooperate in host resistance against Leishmania braziliensis infection
Novais, Fernanda Oliveira
title_short Neutrophils and macrophages cooperate in host resistance against Leishmania braziliensis infection
title_full Neutrophils and macrophages cooperate in host resistance against Leishmania braziliensis infection
title_fullStr Neutrophils and macrophages cooperate in host resistance against Leishmania braziliensis infection
title_full_unstemmed Neutrophils and macrophages cooperate in host resistance against Leishmania braziliensis infection
title_sort Neutrophils and macrophages cooperate in host resistance against Leishmania braziliensis infection
author Novais, Fernanda Oliveira
author_facet Novais, Fernanda Oliveira
Santiago, Rômulo Carvalho
Báfica, Andre Luiz Barbosa
Cunha, Antônio Ricardo Khouri
Macêdo, Lilian Maria Afonso de
Borges, Valéria de Matos
Brodskyn, Claudia Ida
Barral-Netto, Manoel
Barral, Aldina Maria Prado
Oliveira, Camila Indiani de
author_role author
author2 Santiago, Rômulo Carvalho
Báfica, Andre Luiz Barbosa
Cunha, Antônio Ricardo Khouri
Macêdo, Lilian Maria Afonso de
Borges, Valéria de Matos
Brodskyn, Claudia Ida
Barral-Netto, Manoel
Barral, Aldina Maria Prado
Oliveira, Camila Indiani de
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Novais, Fernanda Oliveira
Santiago, Rômulo Carvalho
Báfica, Andre Luiz Barbosa
Cunha, Antônio Ricardo Khouri
Macêdo, Lilian Maria Afonso de
Borges, Valéria de Matos
Brodskyn, Claudia Ida
Barral-Netto, Manoel
Barral, Aldina Maria Prado
Oliveira, Camila Indiani de
Novais, Fernanda Oliveira
Santiago, Rômulo Carvalho
Báfica, Andre Luiz Barbosa
Cunha, Antônio Ricardo Khouri
Macêdo, Lilian Maria Afonso de
Borges, Valéria de Matos
Brodskyn, Claudia Ida
Barral-Netto, Manoel
Barral, Aldina Maria Prado
Oliveira, Camila Indiani de
description Texto completo: acesso restrito. p.8088-8098
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2013-10-31T17:54:26Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/13414
dc.identifier.issn.none.fl_str_mv 0022-1767
dc.identifier.number.pt_BR.fl_str_mv v. 183, n. 12
identifier_str_mv 0022-1767
v. 183, n. 12
url http://repositorio.ufba.br/ri/handle/ri/13414
dc.language.iso.fl_str_mv eng
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