Macrophages participate in host protection and the disease pathology associated with Leishmania braziliensis infection

Detalhes bibliográficos
Autor(a) principal: Giudice, Angela
Data de Publicação: 2012
Outros Autores: Vendrame, Célia, Bezerra, Caroline A., Carvalho, Lucas Pedreira de, Delavechia, Thaís, Carvalho Filho, Edgar Marcelino de, Bacellar, Maria Olívia Amado Ramos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/16189
Resumo: p. 1-9
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spelling Giudice, AngelaVendrame, CéliaBezerra, Caroline A.Carvalho, Lucas Pedreira deDelavechia, ThaísCarvalho Filho, Edgar Marcelino deBacellar, Maria Olívia Amado Ramos2014-09-29T14:30:59Z2014-09-29T14:30:59Z20121471-2334http://repositorio.ufba.br/ri/handle/ri/16189v. 12, n. 75p. 1-9Background Leishmania preferentially infects macrophages, which allow the parasite to multiply but can also kill the parasite. Although the T cell response in human leishmaniasis is well-characterized, little is known about the concomitant macrophage behavior. The aim of this study was to characterize the macrophage immune response after Leishmania braziliensis infection in cells derived from cutaneous leishmaniasis (CL) or mucosal leishmaniasis (ML) patients, subclinical individuals (SC) and healthy control subjects (HS). Methods Peripheral blood mononuclear cell-derived macrophages from the different groups were exposed to L. braziliensis in vitro and were evaluated for susceptibility to Leishmania infection, ability to kill Leishmania and chemokine/cytokine production. Nitric Oxide (NO) and superoxide (O2-) levels in the supernatant of infected macrophage cultures were monitored. Results After exposure to L. braziliensis, peripheral blood mononuclear cell-derived macrophages from SC individuals showed a lower infection rate and a smaller number of intracellular amastigotes compared to cells from CL and ML patients. Macrophages from CL and ML patients produced more chemokines and TNF-α than those from the SC group. Production of NO and O2- were detected but did not vary significantly among the different groups. Conclusions Our data indicate that macrophages play a pivotal role in controlling L. braziliensis infection and in leishmaniasis pathology by secreting pro-inflammatory chemokines/cytokines that activate and recruit T cells, overwhelming the inflammatory response.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-08-18T14:21:12Z No. of bitstreams: 1 Angela Giudice.pdf: 552087 bytes, checksum: 169da8ae593a18e00ab30752fdc13299 (MD5)Approved for entry into archive by Delba Rosa (delba@ufba.br) on 2014-09-29T14:30:59Z (GMT) No. of bitstreams: 1 Angela Giudice.pdf: 552087 bytes, checksum: 169da8ae593a18e00ab30752fdc13299 (MD5)Made available in DSpace on 2014-09-29T14:30:59Z (GMT). No. of bitstreams: 1 Angela Giudice.pdf: 552087 bytes, checksum: 169da8ae593a18e00ab30752fdc13299 (MD5) Previous issue date: 2012http://dx.doi.org/10.1186/1471-2334-12-75reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAL braziliensisMacrophagesChemokinesSubclinical infectionMacrophages participate in host protection and the disease pathology associated with Leishmania braziliensis infectionBMC Infectious Diseasesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessengORIGINALAngela Giudice.pdfAngela Giudice.pdfapplication/pdf552087https://repositorio.ufba.br/bitstream/ri/16189/1/Angela%20Giudice.pdf169da8ae593a18e00ab30752fdc13299MD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/16189/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXTAngela Giudice.pdf.txtAngela Giudice.pdf.txtExtracted texttext/plain37940https://repositorio.ufba.br/bitstream/ri/16189/3/Angela%20Giudice.pdf.txt3b88a65c517146db39e869670e1f2791MD53ri/161892022-02-21 00:10:22.248oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-02-21T03:10:22Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Macrophages participate in host protection and the disease pathology associated with Leishmania braziliensis infection
dc.title.alternative.pt_BR.fl_str_mv BMC Infectious Diseases
title Macrophages participate in host protection and the disease pathology associated with Leishmania braziliensis infection
spellingShingle Macrophages participate in host protection and the disease pathology associated with Leishmania braziliensis infection
Giudice, Angela
L braziliensis
Macrophages
Chemokines
Subclinical infection
title_short Macrophages participate in host protection and the disease pathology associated with Leishmania braziliensis infection
title_full Macrophages participate in host protection and the disease pathology associated with Leishmania braziliensis infection
title_fullStr Macrophages participate in host protection and the disease pathology associated with Leishmania braziliensis infection
title_full_unstemmed Macrophages participate in host protection and the disease pathology associated with Leishmania braziliensis infection
title_sort Macrophages participate in host protection and the disease pathology associated with Leishmania braziliensis infection
author Giudice, Angela
author_facet Giudice, Angela
Vendrame, Célia
Bezerra, Caroline A.
Carvalho, Lucas Pedreira de
Delavechia, Thaís
Carvalho Filho, Edgar Marcelino de
Bacellar, Maria Olívia Amado Ramos
author_role author
author2 Vendrame, Célia
Bezerra, Caroline A.
Carvalho, Lucas Pedreira de
Delavechia, Thaís
Carvalho Filho, Edgar Marcelino de
Bacellar, Maria Olívia Amado Ramos
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Giudice, Angela
Vendrame, Célia
Bezerra, Caroline A.
Carvalho, Lucas Pedreira de
Delavechia, Thaís
Carvalho Filho, Edgar Marcelino de
Bacellar, Maria Olívia Amado Ramos
dc.subject.por.fl_str_mv L braziliensis
Macrophages
Chemokines
Subclinical infection
topic L braziliensis
Macrophages
Chemokines
Subclinical infection
description p. 1-9
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2014-09-29T14:30:59Z
dc.date.available.fl_str_mv 2014-09-29T14:30:59Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/16189
dc.identifier.issn.none.fl_str_mv 1471-2334
dc.identifier.number.pt_BR.fl_str_mv v. 12, n. 75
identifier_str_mv 1471-2334
v. 12, n. 75
url http://repositorio.ufba.br/ri/handle/ri/16189
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1186/1471-2334-12-75
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
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instname_str Universidade Federal da Bahia (UFBA)
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reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
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