Serum cytokine profile among Brazilian children of African descent with periodontal inflammation and sickle cell anaemia

Detalhes bibliográficos
Autor(a) principal: Veiga, Patricia C.
Data de Publicação: 2013
Outros Autores: Schroth, Robert J., Guedes, Rosalina, Freire, Songeli Meneses, Nogueira Filho, Getúlio da Rocha
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/12147
Resumo: Texto completo. Acesso restrito. p. 505–510
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spelling Veiga, Patricia C.Schroth, Robert J.Guedes, RosalinaFreire, Songeli MenesesNogueira Filho, Getúlio da RochaVeiga, Patricia C.Schroth, Robert J.Guedes, RosalinaFreire, Songeli MenesesNogueira Filho, Getúlio da Rocha2013-07-09T12:56:11Z20130003-9969http://www.repositorio.ufba.br/ri/handle/ri/12147v. 58, n. 5Texto completo. Acesso restrito. p. 505–510Objective: The aim of this study was to evaluate possible immunologic relationships between sickle cell anaemia (SCA) and periodontal inflammation and its impact on serum cytokines. Design: Twenty-five Brazilian children of African descent were involved in this study and divided in two groups: SCA (n = 10): confirmed diagnosis of homozygous anaemia; and CTR-control (n = 15): no sickle anaemia. Clinical examination included comprehensive medical (routine physical evaluation) and periodontal exams: plaque index (PI), bleeding on probing (BoP), and haematological analysis. Serum samples were collected for cytokine evaluation by microarray. Clinical and laboratorial parameters were compared statistically (alpha = 5%). Results: The higher values of PI and BoP were similar for both groups ( p > 0.05) confirming a diagnosis of generalized gingivitis for all individuals. Intergroup analysis showed higher levels of interferon gamma (IFNg), tumour necrosis alpha (TNFa), interleukin (IL)-4, -5, -8, -10 and 13 only in the SCA group ( p < 0.05). In addition, PI was negatively correlated with IL-2, IL-4, IL-5, IL-6, IL-8 and IL-13, while BoP was positively correlated with IL-10. Conclusion: Within the limits of the present study, it was concluded that SCA increase the levels of serum cytokines regardless of the presence of periodontal inflammation. Therefore, a direct immunological relationship between SCA and periodontal inflammation was not established.Submitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2013-06-12T19:03:05Z No. of bitstreams: 1 7777777777.pdf: 285962 bytes, checksum: c0e3b0ed2a2e90889211e751257b7caf (MD5)Approved for entry into archive by Flávia Ferreira(flaviaccf@yahoo.com.br) on 2013-07-09T12:56:11Z (GMT) No. of bitstreams: 1 7777777777.pdf: 285962 bytes, checksum: c0e3b0ed2a2e90889211e751257b7caf (MD5)Made available in DSpace on 2013-07-09T12:56:11Z (GMT). No. of bitstreams: 1 7777777777.pdf: 285962 bytes, checksum: c0e3b0ed2a2e90889211e751257b7caf (MD5) Previous issue date: 2013SalvadorArchives of Oral Biologyhttp://dx.doi.org/10.1016/j.archoralbio.2012.11.006reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBASickle cell anaemiaCytokinesGingivitisInflammationAfrican descentSerum cytokine profile among Brazilian children of African descent with periodontal inflammation and sickle cell anaemiaArchives of Oral Biologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINAL7777777777.pdf7777777777.pdfapplication/pdf285962https://repositorio.ufba.br/bitstream/ri/12147/1/7777777777.pdfc0e3b0ed2a2e90889211e751257b7cafMD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/12147/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXT7777777777.pdf.txt7777777777.pdf.txtExtracted texttext/plain30298https://repositorio.ufba.br/bitstream/ri/12147/3/7777777777.pdf.txtcc8cac72b9ba5d4fa3ba5f59ef311cd4MD53ri/121472022-07-05 14:03:37.648oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:37Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Serum cytokine profile among Brazilian children of African descent with periodontal inflammation and sickle cell anaemia
dc.title.alternative.pt_BR.fl_str_mv Archives of Oral Biology
title Serum cytokine profile among Brazilian children of African descent with periodontal inflammation and sickle cell anaemia
spellingShingle Serum cytokine profile among Brazilian children of African descent with periodontal inflammation and sickle cell anaemia
Veiga, Patricia C.
Sickle cell anaemia
Cytokines
Gingivitis
Inflammation
African descent
title_short Serum cytokine profile among Brazilian children of African descent with periodontal inflammation and sickle cell anaemia
title_full Serum cytokine profile among Brazilian children of African descent with periodontal inflammation and sickle cell anaemia
title_fullStr Serum cytokine profile among Brazilian children of African descent with periodontal inflammation and sickle cell anaemia
title_full_unstemmed Serum cytokine profile among Brazilian children of African descent with periodontal inflammation and sickle cell anaemia
title_sort Serum cytokine profile among Brazilian children of African descent with periodontal inflammation and sickle cell anaemia
author Veiga, Patricia C.
author_facet Veiga, Patricia C.
Schroth, Robert J.
Guedes, Rosalina
Freire, Songeli Meneses
Nogueira Filho, Getúlio da Rocha
author_role author
author2 Schroth, Robert J.
Guedes, Rosalina
Freire, Songeli Meneses
Nogueira Filho, Getúlio da Rocha
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Veiga, Patricia C.
Schroth, Robert J.
Guedes, Rosalina
Freire, Songeli Meneses
Nogueira Filho, Getúlio da Rocha
Veiga, Patricia C.
Schroth, Robert J.
Guedes, Rosalina
Freire, Songeli Meneses
Nogueira Filho, Getúlio da Rocha
dc.subject.por.fl_str_mv Sickle cell anaemia
Cytokines
Gingivitis
Inflammation
African descent
topic Sickle cell anaemia
Cytokines
Gingivitis
Inflammation
African descent
description Texto completo. Acesso restrito. p. 505–510
publishDate 2013
dc.date.accessioned.fl_str_mv 2013-07-09T12:56:11Z
dc.date.issued.fl_str_mv 2013
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/12147
dc.identifier.issn.none.fl_str_mv 0003-9969
dc.identifier.number.pt_BR.fl_str_mv v. 58, n. 5
identifier_str_mv 0003-9969
v. 58, n. 5
url http://www.repositorio.ufba.br/ri/handle/ri/12147
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Archives of Oral Biology
publisher.none.fl_str_mv Archives of Oral Biology
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1016/j.archoralbio.2012.11.006
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
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collection Repositório Institucional da UFBA
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