Cytokine profiles in sickle cell anemia: Pathways to be unraveled

Detalhes bibliográficos
Autor(a) principal: Pitanga, Thassila Nogueira
Data de Publicação: 2013
Outros Autores: Vilas-Boas, Wendell, Cerqueira, Bruno Antonio Veloso, Seixas, Magda Oliveira, Barbosa, Cynara Gomes, Adorno, Elisângela Vitória, Goncalves, Marilda Souza
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/14106
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Instituto de Ciência e Tecnologia do Sangue. Campinas, SP, Brasil.
id CRUZ_c60826b5490ac94441e8db84fb874239
oai_identifier_str oai:www.arca.fiocruz.br:icict/14106
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Pitanga, Thassila NogueiraVilas-Boas, WendellCerqueira, Bruno Antonio VelosoSeixas, Magda OliveiraBarbosa, Cynara GomesAdorno, Elisângela VitóriaGoncalves, Marilda Souza2016-05-05T18:29:08Z2016-05-05T18:29:08Z2013PITANGA, Thassila Nogueira et al. Cytokine profiles in sickle cell anemia: Pathways to be unraveled. Advances in Bioscience and Biotechnology, v. 4, p. 6-12, 2013.2156-8456https://www.arca.fiocruz.br/handle/icict/1410610.4236/abb.2013.47A1002engScientific Research PublishingCytokine profiles in sickle cell anemia: Pathways to be unraveledinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Instituto de Ciência e Tecnologia do Sangue. Campinas, SP, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Instituto de Ciência e Tecnologia do Sangue. Campinas, SP, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Instituto de Ciência e Tecnologia do Sangue. Campinas, SP, Brasil / Universidade Estadual de Santa Cruz. Ilhéus, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Instituto de Ciência e Tecnologia do Sangue. Campinas, SP, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Instituto de Ciência e Tecnologia do Sangue. Campinas, SP, Brasil / Universidade Federal da Bahia. Faculdade de Farmacia. Salvador, BA, BrasilInstituto de Ciência e Tecnologia do Sangue. Campinas, SP, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Instituto de Ciência e Tecnologia do Sangue. Campinas, SP, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil.Sickle cell anemia (SCA) is a genetically inherited hemolytic disorder characterized by chronic inflam- mation. Cytokine expression affects the pivotal path- ways that contribute to disease pathogenesis, but the mechanisms involved are not well understood. SCA is associated with a proinflammatory state, and an en- hanced inflammatory response occurs during vaso- occlusive crisis. The immune system thus plays an important role in this inflammatory condition, with several cell types secreting pro-inflammatory cyto- kines that contribute to the occurrence of common cyclical events in SCA patients, such as hemolysis, vascular occlusion and inflammation. Studies of these cytokines and chemokines in SCA patients have clari- fied the mechanisms that underlie this disease and highlighted the need for a better understanding of cytokine participation in SCA pathophysiologySickle Cell AnemiaCytokinesChemokineInflammationInflammasomeinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/14106/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALPitanga TN Cytokine profiles....pdfPitanga TN Cytokine profiles....pdfapplication/pdf279443https://www.arca.fiocruz.br/bitstream/icict/14106/2/Pitanga%20TN%20Cytokine%20profiles....pdf21f2d9101377f5a0e1e7a2703719a842MD52TEXTPitanga TN Cytokine profiles....pdf.txtPitanga TN Cytokine profiles....pdf.txtExtracted texttext/plain39385https://www.arca.fiocruz.br/bitstream/icict/14106/3/Pitanga%20TN%20Cytokine%20profiles....pdf.txtb6e1b652eb869bb967dbb5046d62ac22MD53icict/141062023-03-15 14:34:00.722oai:www.arca.fiocruz.br:icict/14106Q0VTU8ODTyBOw4NPIEVYQ0xVU0lWQSBERSBESVJFSVRPUyBBVVRPUkFJUwoKQW8gYWNlaXRhciBvcyBURVJNT1MgZSBDT05EScOHw5VFUyBkZXN0YSBDRVNTw4NPLCBvIEFVVE9SIGUvb3UgVElUVUxBUiBkZSBkaXJlaXRvcwphdXRvcmFpcyBzb2JyZSBhIE9CUkEgZGUgcXVlIHRyYXRhIGVzdGUgZG9jdW1lbnRvOgoKKDEpIENFREUgZSBUUkFOU0ZFUkUsIHRvdGFsIGUgZ3JhdHVpdGFtZW50ZSwgw6AgRklPQ1JVWiAtIEZVTkRBw4fDg08gT1NXQUxETyBDUlVaLCBlbQpjYXLDoXRlciBwZXJtYW5lbnRlLCBpcnJldm9nw6F2ZWwgZSBOw4NPIEVYQ0xVU0lWTywgdG9kb3Mgb3MgZGlyZWl0b3MgcGF0cmltb25pYWlzIE7Dg08KQ09NRVJDSUFJUyBkZSB1dGlsaXphw6fDo28gZGEgT0JSQSBhcnTDrXN0aWNhIGUvb3UgY2llbnTDrWZpY2EgaW5kaWNhZGEgYWNpbWEsIGluY2x1c2l2ZSBvcyBkaXJlaXRvcwpkZSB2b3ogZSBpbWFnZW0gdmluY3VsYWRvcyDDoCBPQlJBLCBkdXJhbnRlIHRvZG8gbyBwcmF6byBkZSBkdXJhw6fDo28gZG9zIGRpcmVpdG9zIGF1dG9yYWlzLCBlbQpxdWFscXVlciBpZGlvbWEgZSBlbSB0b2RvcyBvcyBwYcOtc2VzOwoKKDIpIEFDRUlUQSBxdWUgYSBjZXNzw6NvIHRvdGFsIG7Do28gZXhjbHVzaXZhLCBwZXJtYW5lbnRlIGUgaXJyZXZvZ8OhdmVsIGRvcyBkaXJlaXRvcyBhdXRvcmFpcwpwYXRyaW1vbmlhaXMgbsOjbyBjb21lcmNpYWlzIGRlIHV0aWxpemHDp8OjbyBkZSBxdWUgdHJhdGEgZXN0ZSBkb2N1bWVudG8gaW5jbHVpLCBleGVtcGxpZmljYXRpdmFtZW50ZSwKb3MgZGlyZWl0b3MgZGUgZGlzcG9uaWJpbGl6YcOnw6NvIGUgY29tdW5pY2HDp8OjbyBww7pibGljYSBkYSBPQlJBLCBlbSBxdWFscXVlciBtZWlvIG91IHZlw61jdWxvLAppbmNsdXNpdmUgZW0gUmVwb3NpdMOzcmlvcyBEaWdpdGFpcywgYmVtIGNvbW8gb3MgZGlyZWl0b3MgZGUgcmVwcm9kdcOnw6NvLCBleGliacOnw6NvLCBleGVjdcOnw6NvLApkZWNsYW1hw6fDo28sIHJlY2l0YcOnw6NvLCBleHBvc2nDp8OjbywgYXJxdWl2YW1lbnRvLCBpbmNsdXPDo28gZW0gYmFuY28gZGUgZGFkb3MsIHByZXNlcnZhw6fDo28sIGRpZnVzw6NvLApkaXN0cmlidWnDp8OjbywgZGl2dWxnYcOnw6NvLCBlbXByw6lzdGltbywgdHJhZHXDp8OjbywgZHVibGFnZW0sIGxlZ2VuZGFnZW0sIGluY2x1c8OjbyBlbSBub3ZhcyBvYnJhcyBvdQpjb2xldMOibmVhcywgcmV1dGlsaXphw6fDo28sIGVkacOnw6NvLCBwcm9kdcOnw6NvIGRlIG1hdGVyaWFsIGRpZMOhdGljbyBlIGN1cnNvcyBvdSBxdWFscXVlciBmb3JtYSBkZQp1dGlsaXphw6fDo28gbsOjbyBjb21lcmNpYWw7CgooMykgUkVDT05IRUNFIHF1ZSBhIGNlc3PDo28gYXF1aSBlc3BlY2lmaWNhZGEgY29uY2VkZSDDoCBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPCkNSVVogbyBkaXJlaXRvIGRlIGF1dG9yaXphciBxdWFscXVlciBwZXNzb2Eg4oCTIGbDrXNpY2Egb3UganVyw61kaWNhLCBww7pibGljYSBvdSBwcml2YWRhLCBuYWNpb25hbCBvdQplc3RyYW5nZWlyYSDigJMgYSBhY2Vzc2FyIGUgdXRpbGl6YXIgYW1wbGFtZW50ZSBhIE9CUkEsIHNlbSBleGNsdXNpdmlkYWRlLCBwYXJhIHF1YWlzcXVlcgpmaW5hbGlkYWRlcyBuw6NvIGNvbWVyY2lhaXM7CgooNCkgREVDTEFSQSBxdWUgYSBvYnJhIMOpIGNyaWHDp8OjbyBvcmlnaW5hbCBlIHF1ZSDDqSBvIHRpdHVsYXIgZG9zIGRpcmVpdG9zIGFxdWkgY2VkaWRvcyBlIGF1dG9yaXphZG9zLApyZXNwb25zYWJpbGl6YW5kby1zZSBpbnRlZ3JhbG1lbnRlIHBlbG8gY29udGXDumRvIGUgb3V0cm9zIGVsZW1lbnRvcyBxdWUgZmF6ZW0gcGFydGUgZGEgT0JSQSwKaW5jbHVzaXZlIG9zIGRpcmVpdG9zIGRlIHZveiBlIGltYWdlbSB2aW5jdWxhZG9zIMOgIE9CUkEsIG9icmlnYW5kby1zZSBhIGluZGVuaXphciB0ZXJjZWlyb3MgcG9yCmRhbm9zLCBiZW0gY29tbyBpbmRlbml6YXIgZSByZXNzYXJjaXIgYSBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPIENSVVogZGUKZXZlbnR1YWlzIGRlc3Blc2FzIHF1ZSB2aWVyZW0gYSBzdXBvcnRhciwgZW0gcmF6w6NvIGRlIHF1YWxxdWVyIG9mZW5zYSBhIGRpcmVpdG9zIGF1dG9yYWlzIG91CmRpcmVpdG9zIGRlIHZveiBvdSBpbWFnZW0sIHByaW5jaXBhbG1lbnRlIG5vIHF1ZSBkaXogcmVzcGVpdG8gYSBwbMOhZ2lvIGUgdmlvbGHDp8O1ZXMgZGUgZGlyZWl0b3M7CgooNSkgQUZJUk1BIHF1ZSBjb25oZWNlIGEgUG9sw610aWNhIEluc3RpdHVjaW9uYWwgZGUgQWNlc3NvIEFiZXJ0byBkYSBGSU9DUlVaIC0gRlVOREHDh8ODTwpPU1dBTERPIENSVVogZSBhcyBkaXJldHJpemVzIHBhcmEgbyBmdW5jaW9uYW1lbnRvIGRvIHJlcG9zaXTDs3JpbyBpbnN0aXR1Y2lvbmFsIEFSQ0EuCgpBIFBvbMOtdGljYSBJbnN0aXR1Y2lvbmFsIGRlIEFjZXNzbyBBYmVydG8gZGEgRklPQ1JVWiAtIEZVTkRBw4fDg08gT1NXQUxETyBDUlVaIHJlc2VydmEKZXhjbHVzaXZhbWVudGUgYW8gQVVUT1Igb3MgZGlyZWl0b3MgbW9yYWlzIGUgb3MgdXNvcyBjb21lcmNpYWlzIHNvYnJlIGFzIG9icmFzIGRlIHN1YSBhdXRvcmlhCmUvb3UgdGl0dWxhcmlkYWRlLCBzZW5kbyBvcyB0ZXJjZWlyb3MgdXN1w6FyaW9zIHJlc3BvbnPDoXZlaXMgcGVsYSBhdHJpYnVpw6fDo28gZGUgYXV0b3JpYSBlIG1hbnV0ZW7Dp8OjbwpkYSBpbnRlZ3JpZGFkZSBkYSBPQlJBIGVtIHF1YWxxdWVyIHV0aWxpemHDp8Ojby4KCkEgUG9sw610aWNhIEluc3RpdHVjaW9uYWwgZGUgQWNlc3NvIEFiZXJ0byBkYSBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPIENSVVoKcmVzcGVpdGEgb3MgY29udHJhdG9zIGUgYWNvcmRvcyBwcmVleGlzdGVudGVzIGRvcyBBdXRvcmVzIGNvbSB0ZXJjZWlyb3MsIGNhYmVuZG8gYW9zIEF1dG9yZXMKaW5mb3JtYXIgw6AgSW5zdGl0dWnDp8OjbyBhcyBjb25kacOnw7VlcyBlIG91dHJhcyByZXN0cmnDp8O1ZXMgaW1wb3N0YXMgcG9yIGVzdGVzIGluc3RydW1lbnRvcy4KRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:34Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Cytokine profiles in sickle cell anemia: Pathways to be unraveled
title Cytokine profiles in sickle cell anemia: Pathways to be unraveled
spellingShingle Cytokine profiles in sickle cell anemia: Pathways to be unraveled
Pitanga, Thassila Nogueira
Sickle Cell Anemia
Cytokines
Chemokine
Inflammation
Inflammasome
title_short Cytokine profiles in sickle cell anemia: Pathways to be unraveled
title_full Cytokine profiles in sickle cell anemia: Pathways to be unraveled
title_fullStr Cytokine profiles in sickle cell anemia: Pathways to be unraveled
title_full_unstemmed Cytokine profiles in sickle cell anemia: Pathways to be unraveled
title_sort Cytokine profiles in sickle cell anemia: Pathways to be unraveled
author Pitanga, Thassila Nogueira
author_facet Pitanga, Thassila Nogueira
Vilas-Boas, Wendell
Cerqueira, Bruno Antonio Veloso
Seixas, Magda Oliveira
Barbosa, Cynara Gomes
Adorno, Elisângela Vitória
Goncalves, Marilda Souza
author_role author
author2 Vilas-Boas, Wendell
Cerqueira, Bruno Antonio Veloso
Seixas, Magda Oliveira
Barbosa, Cynara Gomes
Adorno, Elisângela Vitória
Goncalves, Marilda Souza
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Pitanga, Thassila Nogueira
Vilas-Boas, Wendell
Cerqueira, Bruno Antonio Veloso
Seixas, Magda Oliveira
Barbosa, Cynara Gomes
Adorno, Elisângela Vitória
Goncalves, Marilda Souza
dc.subject.en.pt_BR.fl_str_mv Sickle Cell Anemia
Cytokines
Chemokine
Inflammation
Inflammasome
topic Sickle Cell Anemia
Cytokines
Chemokine
Inflammation
Inflammasome
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Instituto de Ciência e Tecnologia do Sangue. Campinas, SP, Brasil.
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2016-05-05T18:29:08Z
dc.date.available.fl_str_mv 2016-05-05T18:29:08Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv PITANGA, Thassila Nogueira et al. Cytokine profiles in sickle cell anemia: Pathways to be unraveled. Advances in Bioscience and Biotechnology, v. 4, p. 6-12, 2013.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/14106
dc.identifier.issn.none.fl_str_mv 2156-8456
dc.identifier.doi.none.fl_str_mv 10.4236/abb.2013.47A1002
identifier_str_mv PITANGA, Thassila Nogueira et al. Cytokine profiles in sickle cell anemia: Pathways to be unraveled. Advances in Bioscience and Biotechnology, v. 4, p. 6-12, 2013.
2156-8456
10.4236/abb.2013.47A1002
url https://www.arca.fiocruz.br/handle/icict/14106
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Scientific Research Publishing
publisher.none.fl_str_mv Scientific Research Publishing
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/14106/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/14106/2/Pitanga%20TN%20Cytokine%20profiles....pdf
https://www.arca.fiocruz.br/bitstream/icict/14106/3/Pitanga%20TN%20Cytokine%20profiles....pdf.txt
bitstream.checksum.fl_str_mv 5a560609d32a3863062d77ff32785d58
21f2d9101377f5a0e1e7a2703719a842
b6e1b652eb869bb967dbb5046d62ac22
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1798324648308375552

Registros relacionados