Partial benefit of anastrozole in the long-term treatment of precocious puberty in McCune-Albright syndrome

Detalhes bibliográficos
Autor(a) principal: Alves, Crésio de Aragão Dantas
Data de Publicação: 2012
Outros Autores: Silva, Sheila Ferreira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/16165
Resumo: Texto completo: acesso restrito. p. 323–325
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spelling Alves, Crésio de Aragão DantasSilva, Sheila FerreiraAlves, Crésio de Aragão DantasSilva, Sheila Ferreira2014-09-25T14:59:25Z20120334-018Xhttp://repositorio.ufba.br/ri/handle/ri/16165v. 25, n. 3Texto completo: acesso restrito. p. 323–325We report a long-term follow-up on the use of anastrozole in the treatment of peripheral precocious puberty (PP) in McCune-Albright syndrome (MAS). A girl, age 3 years and 9 months, was diagnosed with MAS due to PP, café-au-lait spots, and polyostotic fibrous dysplasia. Serum estradiol was elevated, and gonadotropins were suppressed. Pelvic ultrasound showed an enlarged uterus and a follicle cyst (13 mm) in the left ovary. Bone scintigraphy showed osteogenic lesions on the skull, humerus, tibia, and acetabulum. Bone age was 3 years and 5 months at the chronological age of 3 years. After 36 months of treatment with anastrozole (1 mg/day), there was suppression of breast growth, normalization of growth velocity and serum estradiol, and disappearance of ovarian cysts. However, there was increase in uterine volume, advancement of bone age, and two episodes of vaginal bleeding (18th and 24th months). This report shows the partial benefit of anastrozole in the treatment of peripheral PP of girls with MAS.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-08-13T15:00:03Z No. of bitstreams: 1 Cresio Alves.pdf: 67217 bytes, checksum: d6f5472f439d9a78a1a9cab7721021aa (MD5)Approved for entry into archive by Delba Rosa (delba@ufba.br) on 2014-09-25T14:59:25Z (GMT) No. of bitstreams: 1 Cresio Alves.pdf: 67217 bytes, checksum: d6f5472f439d9a78a1a9cab7721021aa (MD5)Made available in DSpace on 2014-09-25T14:59:25Z (GMT). No. of bitstreams: 1 Cresio Alves.pdf: 67217 bytes, checksum: d6f5472f439d9a78a1a9cab7721021aa (MD5) Previous issue date: 2012http://dx.doi.org/ 10.1515/jpem-2011-0472reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAAnastrazoleAromatase inhibitorsMcCune-Albright syndromePrecocious pubertyPartial benefit of anastrozole in the long-term treatment of precocious puberty in McCune-Albright syndromeJournal of Pediatric Endocrinology and Metabolisminfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINALCresio Alves.pdfCresio Alves.pdfapplication/pdf67217https://repositorio.ufba.br/bitstream/ri/16165/1/Cresio%20Alves.pdfd6f5472f439d9a78a1a9cab7721021aaMD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/16165/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXTCresio Alves.pdf.txtCresio Alves.pdf.txtExtracted texttext/plain16002https://repositorio.ufba.br/bitstream/ri/16165/3/Cresio%20Alves.pdf.txta3f53ff58ce471a7cb6a415ec466d55cMD53ri/161652022-08-08 13:17:27.244oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-08-08T16:17:27Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Partial benefit of anastrozole in the long-term treatment of precocious puberty in McCune-Albright syndrome
dc.title.alternative.pt_BR.fl_str_mv Journal of Pediatric Endocrinology and Metabolism
title Partial benefit of anastrozole in the long-term treatment of precocious puberty in McCune-Albright syndrome
spellingShingle Partial benefit of anastrozole in the long-term treatment of precocious puberty in McCune-Albright syndrome
Alves, Crésio de Aragão Dantas
Anastrazole
Aromatase inhibitors
McCune-Albright syndrome
Precocious puberty
title_short Partial benefit of anastrozole in the long-term treatment of precocious puberty in McCune-Albright syndrome
title_full Partial benefit of anastrozole in the long-term treatment of precocious puberty in McCune-Albright syndrome
title_fullStr Partial benefit of anastrozole in the long-term treatment of precocious puberty in McCune-Albright syndrome
title_full_unstemmed Partial benefit of anastrozole in the long-term treatment of precocious puberty in McCune-Albright syndrome
title_sort Partial benefit of anastrozole in the long-term treatment of precocious puberty in McCune-Albright syndrome
author Alves, Crésio de Aragão Dantas
author_facet Alves, Crésio de Aragão Dantas
Silva, Sheila Ferreira
author_role author
author2 Silva, Sheila Ferreira
author2_role author
dc.contributor.author.fl_str_mv Alves, Crésio de Aragão Dantas
Silva, Sheila Ferreira
Alves, Crésio de Aragão Dantas
Silva, Sheila Ferreira
dc.subject.por.fl_str_mv Anastrazole
Aromatase inhibitors
McCune-Albright syndrome
Precocious puberty
topic Anastrazole
Aromatase inhibitors
McCune-Albright syndrome
Precocious puberty
description Texto completo: acesso restrito. p. 323–325
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2014-09-25T14:59:25Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/16165
dc.identifier.issn.none.fl_str_mv 0334-018X
dc.identifier.number.pt_BR.fl_str_mv v. 25, n. 3
identifier_str_mv 0334-018X
v. 25, n. 3
url http://repositorio.ufba.br/ri/handle/ri/16165
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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