Associations among immunological, parasitological and clinical parameters in canine visceral leishmaniasis: emaciation, spleen parasitism, specific antibodies and leishmanin skin test reaction

Detalhes bibliográficos
Autor(a) principal: Santos, Washington Luis Conrado dos
Data de Publicação: 2008
Outros Autores: Jesus, E. E., Silva, M. Paranhos, Pereira, A. M., Santos, J. C., Baleeiro, C. O., Nascimento, E. G., Moreira, E. D., Oliveira, G. G. S., Carvalho, Lain Carlos Pontes de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/6129
Resumo: Acesso restrito: Texto completo. p. 251-259
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spelling Santos, Washington Luis Conrado dosJesus, E. E.Silva, M. ParanhosPereira, A. M.Santos, J. C.Baleeiro, C. O.Nascimento, E. G.Moreira, E. D.Oliveira, G. G. S.Carvalho, Lain Carlos Pontes de2012-06-14T11:22:35Z20080165-2427http://www.repositorio.ufba.br/ri/handle/ri/6129v. 123, n. 3-4Acesso restrito: Texto completo. p. 251-259Associations among parameters commonly used as markers of infection by Leishmania sp., or of susceptibility to visceral leishmaniasis, were investigated in 325 stray dogs from an area where this disease is endemic. Evidence of infection (presence of Leishmania in splenic cultures, positive leishmanin skin test (LST) or detection of anti-Leishmania antibody activity in the serum) was found in 57% of the animals. Both evidence of weight loss (x2-test, P = 0.0005) and presence of specific antibody activity in the serum (x2-test, P < 0.0001) were directly associated with positive splenic culture. The frequencies of animals with positive splenic culture were directly correlated with the intensities of antibody activity in the serum as measured by ELISA (relative risk of 3.4 for animals with moderate antibody levels and relative risk of 8.43 for animals with high-antibody levels). A negative association was observed between positive leishmanin skin test results and emaciation (x2, P = 0.0089). Furthermore, animals with positive splenic cultures and negative leishmanin skin test results had higher levels of total serum IgG (Kruskal–Wallis test, P = 0.001) and IgG2 (Kruskal–Wallis test, P = 0.05) than animals with negative splenic cultures, and were more emaciated than animals with negative LST results and positive splenic cultures. The data presented herein suggest that associating these common parameters may improve their performance in predicting susceptibility to canine visceral leishmaniasis.Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2012-06-14T11:22:35Z No. of bitstreams: 1 __ac.els-cdn.com_S016524...a6bbdc409521bb03131f24171e0e5.pdf: 159828 bytes, checksum: 302bc73c6665de449a961f1d06af8bd2 (MD5)Made available in DSpace on 2012-06-14T11:22:35Z (GMT). No. of bitstreams: 1 __ac.els-cdn.com_S016524...a6bbdc409521bb03131f24171e0e5.pdf: 159828 bytes, checksum: 302bc73c6665de449a961f1d06af8bd2 (MD5) Previous issue date: 2008http://dx.doi.org/10.1016/j.vetimm.2008.02.004reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBALeishmanin skin testCanine visceral leishmaniasisLeishmania chagasiLeishmania infantumSpleenImmunoglobulin isotypesAssociations among immunological, parasitological and clinical parameters in canine visceral leishmaniasis: emaciation, spleen parasitism, specific antibodies and leishmanin skin test reactionVeterinary Immunology and Immunopathologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINAL__ac.els-cdn.com_S016524...a6bbdc409521bb03131f24171e0e5.pdf__ac.els-cdn.com_S016524...a6bbdc409521bb03131f24171e0e5.pdfapplication/pdf159828https://repositorio.ufba.br/bitstream/ri/6129/1/__ac.els-cdn.com_S016524...a6bbdc409521bb03131f24171e0e5.pdf302bc73c6665de449a961f1d06af8bd2MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/6129/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXT__ac.els-cdn.com_S016524...a6bbdc409521bb03131f24171e0e5.pdf.txt__ac.els-cdn.com_S016524...a6bbdc409521bb03131f24171e0e5.pdf.txtExtracted texttext/plain41911https://repositorio.ufba.br/bitstream/ri/6129/3/__ac.els-cdn.com_S016524...a6bbdc409521bb03131f24171e0e5.pdf.txt909b9ebe0047c222dc589ccbabcad8b1MD53ri/61292022-06-01 22:19:51.959oai:repositorio.ufba.br:ri/6129VGVybW8gZGUgTGljZW7vv71hLCBu77+9byBleGNsdXNpdm8sIHBhcmEgbyBkZXDvv71zaXRvIG5vIHJlcG9zaXTvv71yaW8gSW5zdGl0dWNpb25hbCBkYSBVRkJBCgogICAgUGVsbyBwcm9jZXNzbyBkZSBzdWJtaXNz77+9byBkZSBkb2N1bWVudG9zLCBvIGF1dG9yIG91IHNldQpyZXByZXNlbnRhbnRlIGxlZ2FsLCBhbyBhY2VpdGFyIGVzc2UgdGVybW8gZGUgbGljZW7vv71hLCBjb25jZWRlIGFvClJlcG9zaXTvv71yaW8gSW5zdGl0dWNpb25hbCBkYSBVbml2ZXJzaWRhZGUgRmVkZXJhbCBkYSBCYWhpYSBvIGRpcmVpdG8KZGUgbWFudGVyIHVtYSBj77+9cGlhIGVtIHNldSByZXBvc2l077+9cmlvIGNvbSBhIGZpbmFsaWRhZGUsIHByaW1laXJhLCAKZGUgcHJlc2VydmHvv73vv71vLiBFc3NlcyB0ZXJtb3MsIG7vv71vIGV4Y2x1c2l2b3MsIG1hbnTvv71tIG9zIGRpcmVpdG9zIGRlIAphdXRvci9jb3B5cmlnaHQsIG1hcyBlbnRlbmRlIG8gZG9jdW1lbnRvIGNvbW8gcGFydGUgZG8gYWNlcnZvIGludGVsZWN0dWFsIGRlc3NhIFVuaXZlcnNpZGFkZS4gCgogICAgUGFyYSBvcyBkb2N1bWVudG9zIHB1YmxpY2Fkb3MgY29tIHJlcGFzc2UgZGUgZGlyZWl0b3MgZGUgZGlzdHJpYnVp77+977+9bywgZXNzZSB0ZXJtbyBkZSBsaWNlbu+/vWEgZW50ZW5kZSBxdWU6IAoKICAgIE1hbnRlbmRvIG9zICBkaXJlaXRvcyBhdXRvcmFpcywgcmVwYXNzYWRvcyBhIHRlcmNlaXJvcywgZW0gY2FzbyAKZGUgcHVibGljYe+/ve+/vWVzLCBvIHJlcG9zaXTvv71yaW8gcG9kZSByZXN0cmluZ2lyIG8gYWNlc3NvIGFvIHRleHRvIAppbnRlZ3JhbCwgbWFzIGxpYmVyYSBhcyBpbmZvcm1h77+977+9ZXMgc29icmUgbyBkb2N1bWVudG8gKE1ldGFkYWRvcyBkZXNjcml0aXZvcykuCgogRGVzdGEgZm9ybWEsIGF0ZW5kZW5kbyBhb3MgYW5zZWlvcyBkZXNzYSB1bml2ZXJzaWRhZGUgCmVtIG1hbnRlciBzdWEgcHJvZHXvv73vv71vIGNpZW5077+9ZmljYSBjb20gYXMgcmVzdHJp77+977+9ZXMgaW1wb3N0YXMgcGVsb3MgCmVkaXRvcmVzIGRlIHBlcmnvv71kaWNvcy4gCgogICAgUGFyYSBhcyBwdWJsaWNh77+977+9ZXMgZW0gaW5pY2lhdGl2YXMgcXVlIHNlZ3VlbSBhIHBvbO+/vXRpY2EgZGUgCkFjZXNzbyBBYmVydG8sIG9zIGRlcO+/vXNpdG9zIGNvbXB1bHPvv71yaW9zIG5lc3NlIHJlcG9zaXTvv71yaW8gbWFudO+/vW0gCm9zIGRpcmVpdG9zIGF1dG9yYWlzLCBtYXMgbWFudO+/vW0gbyBhY2Vzc28gaXJyZXN0cml0byBhbyBtZXRhZGFkb3MgCmUgdGV4dG8gY29tcGxldG8uIEFzc2ltLCBhIGFjZWl0Ye+/ve+/vW8gZGVzc2UgdGVybW8gbu+/vW8gbmVjZXNzaXRhIGRlIApjb25zZW50aW1lbnRvIHBvciBwYXJ0ZSBkZSBhdXRvcmVzL2RldGVudG9yZXMgZG9zIGRpcmVpdG9zLCBwb3IgCmVzdGFyZW0gZW0gaW5pY2lhdGl2YXMgZGUgYWNlc3NvIGFiZXJ0by4KCiAgICBFbSBhbWJvcyBvIGNhc28sIGVzc2UgdGVybW8gZGUgbGljZW7vv71hLCBwb2RlIHNlciBhY2VpdG8gcGVsbyAKYXV0b3IsIGRldGVudG9yZXMgZGUgZGlyZWl0b3MgZS9vdSB0ZXJjZWlyb3MgYW1wYXJhZG9zIHBlbGEgCnVuaXZlcnNpZGFkZS4gRGV2aWRvIGFvcyBkaWZlcmVudGVzIHByb2Nlc3NvcyBwZWxvIHF1YWwgYSBzdWJtaXNz77+9byAKcG9kZSBvY29ycmVyLCBvIHJlcG9zaXTvv71yaW8gcGVybWl0ZSBhIGFjZWl0Ye+/ve+/vW8gZGEgbGljZW7vv71hIHBvciAKdGVyY2Vpcm9zLCBzb21lbnRlIG5vcyBjYXNvcyBkZSBkb2N1bWVudG9zIHByb2R1emlkb3MgcG9yIGludGVncmFudGVzIApkYSBVRkJBIGUgc3VibWV0aWRvcyBwb3IgcGVzc29hcyBhbXBhcmFkYXMgcG9yIGVzdGEgaW5zdGl0dWnvv73vv71vLgo=Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-06-02T01:19:51Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Associations among immunological, parasitological and clinical parameters in canine visceral leishmaniasis: emaciation, spleen parasitism, specific antibodies and leishmanin skin test reaction
dc.title.alternative.pt_BR.fl_str_mv Veterinary Immunology and Immunopathology
title Associations among immunological, parasitological and clinical parameters in canine visceral leishmaniasis: emaciation, spleen parasitism, specific antibodies and leishmanin skin test reaction
spellingShingle Associations among immunological, parasitological and clinical parameters in canine visceral leishmaniasis: emaciation, spleen parasitism, specific antibodies and leishmanin skin test reaction
Santos, Washington Luis Conrado dos
Leishmanin skin test
Canine visceral leishmaniasis
Leishmania chagasi
Leishmania infantum
Spleen
Immunoglobulin isotypes
title_short Associations among immunological, parasitological and clinical parameters in canine visceral leishmaniasis: emaciation, spleen parasitism, specific antibodies and leishmanin skin test reaction
title_full Associations among immunological, parasitological and clinical parameters in canine visceral leishmaniasis: emaciation, spleen parasitism, specific antibodies and leishmanin skin test reaction
title_fullStr Associations among immunological, parasitological and clinical parameters in canine visceral leishmaniasis: emaciation, spleen parasitism, specific antibodies and leishmanin skin test reaction
title_full_unstemmed Associations among immunological, parasitological and clinical parameters in canine visceral leishmaniasis: emaciation, spleen parasitism, specific antibodies and leishmanin skin test reaction
title_sort Associations among immunological, parasitological and clinical parameters in canine visceral leishmaniasis: emaciation, spleen parasitism, specific antibodies and leishmanin skin test reaction
author Santos, Washington Luis Conrado dos
author_facet Santos, Washington Luis Conrado dos
Jesus, E. E.
Silva, M. Paranhos
Pereira, A. M.
Santos, J. C.
Baleeiro, C. O.
Nascimento, E. G.
Moreira, E. D.
Oliveira, G. G. S.
Carvalho, Lain Carlos Pontes de
author_role author
author2 Jesus, E. E.
Silva, M. Paranhos
Pereira, A. M.
Santos, J. C.
Baleeiro, C. O.
Nascimento, E. G.
Moreira, E. D.
Oliveira, G. G. S.
Carvalho, Lain Carlos Pontes de
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Santos, Washington Luis Conrado dos
Jesus, E. E.
Silva, M. Paranhos
Pereira, A. M.
Santos, J. C.
Baleeiro, C. O.
Nascimento, E. G.
Moreira, E. D.
Oliveira, G. G. S.
Carvalho, Lain Carlos Pontes de
dc.subject.por.fl_str_mv Leishmanin skin test
Canine visceral leishmaniasis
Leishmania chagasi
Leishmania infantum
Spleen
Immunoglobulin isotypes
topic Leishmanin skin test
Canine visceral leishmaniasis
Leishmania chagasi
Leishmania infantum
Spleen
Immunoglobulin isotypes
description Acesso restrito: Texto completo. p. 251-259
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2012-06-14T11:22:35Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/6129
dc.identifier.issn.none.fl_str_mv 0165-2427
dc.identifier.number.pt_BR.fl_str_mv v. 123, n. 3-4
identifier_str_mv 0165-2427
v. 123, n. 3-4
url http://www.repositorio.ufba.br/ri/handle/ri/6129
dc.language.iso.fl_str_mv eng
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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