Associations among immunological, parasitological and clinical parameters in canine visceral leishmaniasis: Emaciation, spleen parasitism, specific antibodies and leishmanin skin test reaction.

dosSantos, Washington Luis Conrado; Jesus, E. E; Silva, Moacir Paranhos; Pereira, Andréa Mendes; Santos, Juliana C.; Baleeiro, Carolina de Oliveira; Nascimento, Eliane Góes; Moreira Júnior, Edson Duarte; Oliveira, Geraldo Gileno de Sá; Pontes-de-Carvalho, Lain Carlos

Associations among immunological, parasitological and clinical parameters in canine visceral leishmaniasis: Emaciation, spleen parasitism, specific antibodies and leishmanin skin test reaction.

Detalhes bibliográficos
Autor(a) principal:	dosSantos, Washington Luis Conrado
Data de Publicação:	2008
Outros Autores:	Jesus, E. E, Silva, Moacir Paranhos, Pereira, Andréa Mendes, Santos, Juliana C., Baleeiro, Carolina de Oliveira, Nascimento, Eliane Góes, Moreira Júnior, Edson Duarte, Oliveira, Geraldo Gileno de Sá, Pontes-de-Carvalho, Lain Carlos
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/7650
Resumo:	Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil

Metadados do item

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spelling	dosSantos, Washington Luis ConradoJesus, E. ESilva, Moacir ParanhosPereira, Andréa MendesSantos, Juliana C.Baleeiro, Carolina de OliveiraNascimento, Eliane GóesMoreira Júnior, Edson DuarteOliveira, Geraldo Gileno de SáPontes-de-Carvalho, Lain Carlos2014-05-23T19:03:53Z2014-05-23T19:03:53Z2008SANTOS, Washington Luis Conrado dos et al. Associations among immunological, parasitological and clinical parameters in canine visceral leishmaniasis: Emaciation, spleen parasitism, specific antibodies and leishmanin skin test reaction. Veterinary Immunology and Immunopathology, v. 123, p. 251–259, 2008.0165-2427https://www.arca.fiocruz.br/handle/icict/765010.1016/j.vetimm.2008.02.004engElsevier Science B.VAssociations among immunological, parasitological and clinical parameters in canine visceral leishmaniasis: Emaciation, spleen parasitism, specific antibodies and leishmanin skin test reaction.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilCentro de Referência em Doenças Endêmicas Pirajá da Silva-PIEJ. CSU. Jequié, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilAssociations among parameters commonly used as markers of infection by Leishmania sp., or of susceptibility to visceral leishmaniasis, were investigated in 325 stray dogs from an area where this disease is endemic. Evidence of infection (presence of Leishmania in splenic cultures, positive leishmanin skin test (LST) or detection of anti-Leishmania antibody activity in the serum) was found in 57% of the animals. Both evidence of weight loss (x2-test, P = 0.0005) and presence of specific antibody activity in the serum (x2-test, P < 0.0001) were directly associated with positive splenic culture. The frequencies of animals with positive splenic culture were directly correlated with the intensities of antibody activity in the serum as measured by ELISA (relative risk of 3.4 for animals with moderate antibody levels and relative risk of 8.43 for animals with high-antibody levels). A negative association was observed between positive leishmanin skin test results and emaciation (x2, P = 0.0089). Furthermore, animals with positive splenic cultures and negative leishmanin skin test results had higher levels of total serum IgG (Kruskal–Wallis test, P = 0.001) and IgG2 (Kruskal–Wallis test, P = 0.05) than animals with negative splenic cultures, and were more emaciated than animals with negative LST results and positive splenic cultures. The data presented herein suggest that associating these common parameters may improve their performance in predicting susceptibility to canine visceral leishmaniasis.Leishmanin skin testCanine visceral leishmaniasisLeishmania chagasiLeishmania infantum; Spleen; Immunoglobulin isotypesAnticorpos Antiprotozoários/imunologiaDoenças do Cão/imunologiaLeishmania/imunologiaLeishmaniose Visceral/veterináriaBaço/parasitologiaAnimaisAnticorpos Antiprotozoários/sangueEspecificidade de AnticorposAntígenos de Protozoários/uso diagnósticoCãesEmaciação/imunologiaEnsaio de Imunoadsorção Enzimática/veterináriaFemininoLeishmaniose Visceral/imunologiaMasculinoBaço/imunologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALDos-Santos WL Associations among....pdfDos-Santos WL Associations among....pdfapplication/pdf214280https://www.arca.fiocruz.br/bitstream/icict/7650/1/Dos-Santos%20WL%20Associations%20among....pdf4d514a9ea7bc98107a575d2f760b61edMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7650/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTDos-Santos WL Associations among....pdf.txtDos-Santos WL Associations among....pdf.txtExtracted texttext/plain42141https://www.arca.fiocruz.br/bitstream/icict/7650/5/Dos-Santos%20WL%20Associations%20among....pdf.txtfc27f3dbe5c3990bfa339d13aa2b3bf8MD55THUMBNAILDos-Santos WL Associations among....pdf.jpgDos-Santos WL Associations among....pdf.jpgGenerated Thumbnailimage/jpeg2254https://www.arca.fiocruz.br/bitstream/icict/7650/4/Dos-Santos%20WL%20Associations%20among....pdf.jpg90079c5d9afbbfd5efaf81ec83d34104MD54icict/76502023-03-15 14:34:16.349oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:34:16Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv	Associations among immunological, parasitological and clinical parameters in canine visceral leishmaniasis: Emaciation, spleen parasitism, specific antibodies and leishmanin skin test reaction.
title	Associations among immunological, parasitological and clinical parameters in canine visceral leishmaniasis: Emaciation, spleen parasitism, specific antibodies and leishmanin skin test reaction.
spellingShingle	Associations among immunological, parasitological and clinical parameters in canine visceral leishmaniasis: Emaciation, spleen parasitism, specific antibodies and leishmanin skin test reaction. dosSantos, Washington Luis Conrado Leishmanin skin test Canine visceral leishmaniasis Leishmania chagasi Leishmania infantum; Spleen; Immunoglobulin isotypes Anticorpos Antiprotozoários/imunologia Doenças do Cão/imunologia Leishmania/imunologia Leishmaniose Visceral/veterinária Baço/parasitologia Animais Anticorpos Antiprotozoários/sangue Especificidade de Anticorpos Antígenos de Protozoários/uso diagnóstico Cães Emaciação/imunologia Ensaio de Imunoadsorção Enzimática/veterinária Feminino Leishmaniose Visceral/imunologia Masculino Baço/imunologia
title_short	Associations among immunological, parasitological and clinical parameters in canine visceral leishmaniasis: Emaciation, spleen parasitism, specific antibodies and leishmanin skin test reaction.
title_full	Associations among immunological, parasitological and clinical parameters in canine visceral leishmaniasis: Emaciation, spleen parasitism, specific antibodies and leishmanin skin test reaction.
title_fullStr	Associations among immunological, parasitological and clinical parameters in canine visceral leishmaniasis: Emaciation, spleen parasitism, specific antibodies and leishmanin skin test reaction.
title_full_unstemmed	Associations among immunological, parasitological and clinical parameters in canine visceral leishmaniasis: Emaciation, spleen parasitism, specific antibodies and leishmanin skin test reaction.
title_sort	Associations among immunological, parasitological and clinical parameters in canine visceral leishmaniasis: Emaciation, spleen parasitism, specific antibodies and leishmanin skin test reaction.
author	dosSantos, Washington Luis Conrado
author_facet	dosSantos, Washington Luis Conrado Jesus, E. E Silva, Moacir Paranhos Pereira, Andréa Mendes Santos, Juliana C. Baleeiro, Carolina de Oliveira Nascimento, Eliane Góes Moreira Júnior, Edson Duarte Oliveira, Geraldo Gileno de Sá Pontes-de-Carvalho, Lain Carlos
author_role	author
author2	Jesus, E. E Silva, Moacir Paranhos Pereira, Andréa Mendes Santos, Juliana C. Baleeiro, Carolina de Oliveira Nascimento, Eliane Góes Moreira Júnior, Edson Duarte Oliveira, Geraldo Gileno de Sá Pontes-de-Carvalho, Lain Carlos
author2_role	author author author author author author author author author
dc.contributor.author.fl_str_mv	dosSantos, Washington Luis Conrado Jesus, E. E Silva, Moacir Paranhos Pereira, Andréa Mendes Santos, Juliana C. Baleeiro, Carolina de Oliveira Nascimento, Eliane Góes Moreira Júnior, Edson Duarte Oliveira, Geraldo Gileno de Sá Pontes-de-Carvalho, Lain Carlos
dc.subject.en.pt_BR.fl_str_mv	Leishmanin skin test Canine visceral leishmaniasis Leishmania chagasi Leishmania infantum; Spleen; Immunoglobulin isotypes
topic	Leishmanin skin test Canine visceral leishmaniasis Leishmania chagasi Leishmania infantum; Spleen; Immunoglobulin isotypes Anticorpos Antiprotozoários/imunologia Doenças do Cão/imunologia Leishmania/imunologia Leishmaniose Visceral/veterinária Baço/parasitologia Animais Anticorpos Antiprotozoários/sangue Especificidade de Anticorpos Antígenos de Protozoários/uso diagnóstico Cães Emaciação/imunologia Ensaio de Imunoadsorção Enzimática/veterinária Feminino Leishmaniose Visceral/imunologia Masculino Baço/imunologia
dc.subject.decs.pt_BR.fl_str_mv	Anticorpos Antiprotozoários/imunologia Doenças do Cão/imunologia Leishmania/imunologia Leishmaniose Visceral/veterinária Baço/parasitologia Animais Anticorpos Antiprotozoários/sangue Especificidade de Anticorpos Antígenos de Protozoários/uso diagnóstico Cães Emaciação/imunologia Ensaio de Imunoadsorção Enzimática/veterinária Feminino Leishmaniose Visceral/imunologia Masculino Baço/imunologia
description	Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
publishDate	2008
dc.date.issued.fl_str_mv	2008
dc.date.accessioned.fl_str_mv	2014-05-23T19:03:53Z
dc.date.available.fl_str_mv	2014-05-23T19:03:53Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	SANTOS, Washington Luis Conrado dos et al. Associations among immunological, parasitological and clinical parameters in canine visceral leishmaniasis: Emaciation, spleen parasitism, specific antibodies and leishmanin skin test reaction. Veterinary Immunology and Immunopathology, v. 123, p. 251–259, 2008.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/7650
dc.identifier.issn.none.fl_str_mv	0165-2427
dc.identifier.doi.pt_BR.fl_str_mv	10.1016/j.vetimm.2008.02.004
identifier_str_mv	SANTOS, Washington Luis Conrado dos et al. Associations among immunological, parasitological and clinical parameters in canine visceral leishmaniasis: Emaciation, spleen parasitism, specific antibodies and leishmanin skin test reaction. Veterinary Immunology and Immunopathology, v. 123, p. 251–259, 2008. 0165-2427 10.1016/j.vetimm.2008.02.004
url	https://www.arca.fiocruz.br/handle/icict/7650
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Elsevier Science B.V
publisher.none.fl_str_mv	Elsevier Science B.V
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
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Associations among immunological, parasitological and clinical parameters in canine visceral leishmaniasis: Emaciation, spleen parasitism, specific antibodies and leishmanin skin test reaction.

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