Effect of 670-nm laser therapy and dexamethasone on tissue repair: a histological and ultrastructural study

Detalhes bibliográficos
Autor(a) principal: Reis, Sílvia R. A.
Data de Publicação: 2008
Outros Autores: Medrado, Alena Ribeiro Alves Peixoto, Marchionni, Antönio Márcio T., Figueira, Claúdio, Fracassi, Larissa D., Knop, Luégya A. H.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/14639
Resumo: Texto completo: acesso restrito. p. 307-313
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spelling Reis, Sílvia R. A.Medrado, Alena Ribeiro Alves PeixotoMarchionni, Antönio Márcio T.Figueira, ClaúdioFracassi, Larissa D.Knop, Luégya A. H.Reis, Sílvia R. A.Medrado, Alena Ribeiro Alves PeixotoMarchionni, Antönio Márcio T.Figueira, ClaúdioFracassi, Larissa D.Knop, Luégya A. H.2014-02-19T18:29:44Z20081549-5418http://repositorio.ufba.br/ri/handle/ri/14639v. 26, n. 4Texto completo: acesso restrito. p. 307-313Objective: In this study we investigated the role of extracellular matrix elements and cells during the wound healing phases following the use of low-level laser therapy (LLLT) and anti-inflammatory drugs. Background Data: There are few scientific studies that characterize the possible interactions of LLLT and anti-inflammatory medications. Materials and Methods: Thirty-two rats submitted to a wound inflicted with a 6-mm-diameter punch. The animals were divided into four groups: sham treated, those treated with the GaAlAs laser (4 J/cm2, 9 mW, λ = 670 nm, spot size 28.27 × 10−2 cm2), those treated with dexamethasone (2 mg/kg), and those treated with both LLLT and dexamethasone. After 3 and 5 d, the cutaneous wounds were assessed by histopathology using polarized light and ultrastructural assessment using transmission electron microscopy. Changes seen in polymorphonuclear inflammatory cells, edema, mononuclear cells, and collagen fiber deposition were semi-quantitatively evaluated. Results: The laser-treated group demonstrated increased collagen content and better arrangement of the extracellular matrix (p < 0.05). Fibroblasts in these tissues were increased in number and were more synthetically active. In the dexamethasone group, the collagen was shown to be non-homogenous and disorganized, with a scarcity of fibroblasts. In the group treated with both types of therapy, fibroblasts were more common and they exhibited vigorous rough endoplasmic reticulum, but they had less collagen production compared to those seen in the laser group. Conclusion: LLLT alone accelerates post-surgical tissue repair and reduces edema and the polymorphonuclear infiltrate even in the presence of dexamethasone.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-11-29T10:19:27Z No. of bitstreams: 1 pho%2E2007%2E2151.pdf: 1048576 bytes, checksum: 188ee7f0ad96c0bf264cd579cbefe8a1 (MD5)Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2014-02-19T18:29:44Z (GMT) No. of bitstreams: 1 pho%2E2007%2E2151.pdf: 1048576 bytes, checksum: 188ee7f0ad96c0bf264cd579cbefe8a1 (MD5)Made available in DSpace on 2014-02-19T18:29:44Z (GMT). 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dc.title.pt_BR.fl_str_mv Effect of 670-nm laser therapy and dexamethasone on tissue repair: a histological and ultrastructural study
dc.title.alternative.pt_BR.fl_str_mv Photomedicine and Laser Surgery
title Effect of 670-nm laser therapy and dexamethasone on tissue repair: a histological and ultrastructural study
spellingShingle Effect of 670-nm laser therapy and dexamethasone on tissue repair: a histological and ultrastructural study
Reis, Sílvia R. A.
Laser Therapy
Extracellular Matrix
Dexamethasone
title_short Effect of 670-nm laser therapy and dexamethasone on tissue repair: a histological and ultrastructural study
title_full Effect of 670-nm laser therapy and dexamethasone on tissue repair: a histological and ultrastructural study
title_fullStr Effect of 670-nm laser therapy and dexamethasone on tissue repair: a histological and ultrastructural study
title_full_unstemmed Effect of 670-nm laser therapy and dexamethasone on tissue repair: a histological and ultrastructural study
title_sort Effect of 670-nm laser therapy and dexamethasone on tissue repair: a histological and ultrastructural study
author Reis, Sílvia R. A.
author_facet Reis, Sílvia R. A.
Medrado, Alena Ribeiro Alves Peixoto
Marchionni, Antönio Márcio T.
Figueira, Claúdio
Fracassi, Larissa D.
Knop, Luégya A. H.
author_role author
author2 Medrado, Alena Ribeiro Alves Peixoto
Marchionni, Antönio Márcio T.
Figueira, Claúdio
Fracassi, Larissa D.
Knop, Luégya A. H.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Reis, Sílvia R. A.
Medrado, Alena Ribeiro Alves Peixoto
Marchionni, Antönio Márcio T.
Figueira, Claúdio
Fracassi, Larissa D.
Knop, Luégya A. H.
Reis, Sílvia R. A.
Medrado, Alena Ribeiro Alves Peixoto
Marchionni, Antönio Márcio T.
Figueira, Claúdio
Fracassi, Larissa D.
Knop, Luégya A. H.
dc.subject.por.fl_str_mv Laser Therapy
Extracellular Matrix
Dexamethasone
topic Laser Therapy
Extracellular Matrix
Dexamethasone
description Texto completo: acesso restrito. p. 307-313
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2014-02-19T18:29:44Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/14639
dc.identifier.issn.none.fl_str_mv 1549-5418
dc.identifier.number.pt_BR.fl_str_mv v. 26, n. 4
identifier_str_mv 1549-5418
v. 26, n. 4
url http://repositorio.ufba.br/ri/handle/ri/14639
dc.language.iso.fl_str_mv eng
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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collection Repositório Institucional da UFBA
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