Chemokines and chemokine receptors coordinate the inflammatory immune response in human cutaneous leishmaniasis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2010 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.1016/j.humimm.2010.09.002 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/7388 |
Resumo: | University of São Paulo. School of Medicine of Ribeirão Preto. Department of Biochemistry and Immunology. São Paulo, SP, Brasil / University of São Paulo. Bauru Dental School. Department of Biological Sciences. São Paulo, SP. Brasil |
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Campanelli, Ana PaulaBrodskyn, Claudia IdaOliveira, Viviane Sampaio Boaventura deSilva, ClaireRoselino, Ana MCosta, Jackson Mauricio LopesSaldanha, Ana Cristina RodriguesFreitas, Luiz Antonio Rodrigues deOliveira, Camila Indiani deBarral Netto, ManoelSilva, João Santana daBarral, Aldina Maria Prado2014-03-10T17:31:47Z2014-03-10T17:31:47Z2010CAMPANELLI, A. P. et al. Chemokines and chemokine receptors coordinate the inflammatory immune response in human cutaneous leishmaniasis. Human Immunology, v. 71, n. 12, p. 1220-1227, 2010.1879-1166https://www.arca.fiocruz.br/handle/icict/738810.1016/j.humimm.2010.09.002engElsevierChemokines and chemokine receptors coordinate the inflammatory immune response in human cutaneous leishmaniasisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversity of São Paulo. School of Medicine of Ribeirão Preto. Department of Biochemistry and Immunology. São Paulo, SP, Brasil / University of São Paulo. Bauru Dental School. Department of Biological Sciences. São Paulo, SP. BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia (INCT). Instituto de Investigação em Imunologia. São Paulo, SP, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilUniversity of São Paulo. School of Medicine. Division of Dermatology. Ribeirão Preto, SP, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil / Instituto Nacional de Ciéncia e Tecnologia (INCT). Instituto de Investigação em Imunologia. São Paulo, SP, BrasilUniversity of São Paulo. School of Medicine of Ribeirão Preto. Department of Biochemistry and Immunology. São Paulo, SP, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil / Instituto Nacional de Ciéncia e Tecnologia (INCT). Instituto de Investigação em Imunologia. São Paulo, SP, BrasilCutaneous leishmaniasis (CL) includes different clinical manifestations displaying diverse intensities of dermal inflammatory infiltrate. Diffuse CL (DCL) cases are hyporesponsive, and lesions show very few lymphocytes and a predominance of macrophages. In contrast, localized CL (LCL) cases are responsive to leishmanial antigen, and lesions exhibit granulocytes and mononuclear cell infiltration in the early phases, changing to a pattern with numerous lymphocytes and macrophages later in the lesion. Therefore, different chemokines may affect the predominance of cell infiltration in distinct clinical manifestations. In lesions from LCL patients, we examined by flow cytometry the presence of different chemokines and their receptors in T cells, and we verified a higher expression of CXCR3 in the early stages of LCL (less than 30 days of infection) and a higher expression of CCR4 in the late stages of disease (more than 60 days of infection). We also observed a higher frequency of T cells producing IL-10 in the late stage of LCL. Using immunohistochemistry, we observed a higher expression of CCL7, CCL17 in lesions from late LCL, as well as CCR4 suggesting a preferential recruitment of regulatory T cells in the late LCL. Comparing lesions from LCL and DCL patients, we observed a higher frequency of CCL7 in DCL lesions. These results point out the importance of the chemokines, defining the different types of cells recruited to the site of the infection, which could be related to the outcome of infection as well as the clinical form observed.ChemokinesCutaneous leishmaniasisInflammationReceptores de Quimiocinas/imunologiaQuimiocinas/imunologiaInflamação/imunologiaLeishmaniose Cutânea/imunologiaLeishmaniose Cutânea/patologiaLinfócitos T/metabolismoAdolescenteAdultoQuimiocinas/metabolismoCriançaFemininoCitometria de FluxoHumanosImuno-HistoquímicaLeishmaniose Tegumentar Difusa/imunologiaLeishmaniose Tegumentar Difusa/patologiaMeia-IdadeMasculinoReceptores de Quimiocinas/metabolismoLinfócitos T/imunologiaAdulto Joveminfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALCampanelli A P Chemokines and....pdfCampanelli A P Chemokines and....pdfapplication/pdf1450332https://www.arca.fiocruz.br/bitstream/icict/7388/1/Campanelli%20A%20P%20Chemokines%20and....pdff6a5e82e70e45252fca6bcd4b5ef0caeMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7388/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTCampanelli A P Chemokines and....pdf.txtCampanelli A P Chemokines and....pdf.txtExtracted texttext/plain37558https://www.arca.fiocruz.br/bitstream/icict/7388/5/Campanelli%20A%20P%20Chemokines%20and....pdf.txtc40077699d1c321535f1961c3fc3ca57MD55THUMBNAILCampanelli A P Chemokines and....pdf.jpgCampanelli A P Chemokines and....pdf.jpgGenerated Thumbnailimage/jpeg2315https://www.arca.fiocruz.br/bitstream/icict/7388/4/Campanelli%20A%20P%20Chemokines%20and....pdf.jpga29bda6286f165e83765eab83242cf7dMD54icict/73882023-03-15 14:32:58.666oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:58Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Chemokines and chemokine receptors coordinate the inflammatory immune response in human cutaneous leishmaniasis |
| title |
Chemokines and chemokine receptors coordinate the inflammatory immune response in human cutaneous leishmaniasis |
| spellingShingle |
Chemokines and chemokine receptors coordinate the inflammatory immune response in human cutaneous leishmaniasis Campanelli, Ana Paula Chemokines Cutaneous leishmaniasis Inflammation Receptores de Quimiocinas/imunologia Quimiocinas/imunologia Inflamação/imunologia Leishmaniose Cutânea/imunologia Leishmaniose Cutânea/patologia Linfócitos T/metabolismo Adolescente Adulto Quimiocinas/metabolismo Criança Feminino Citometria de Fluxo Humanos Imuno-Histoquímica Leishmaniose Tegumentar Difusa/imunologia Leishmaniose Tegumentar Difusa/patologia Meia-Idade Masculino Receptores de Quimiocinas/metabolismo Linfócitos T/imunologia Adulto Jovem |
| title_short |
Chemokines and chemokine receptors coordinate the inflammatory immune response in human cutaneous leishmaniasis |
| title_full |
Chemokines and chemokine receptors coordinate the inflammatory immune response in human cutaneous leishmaniasis |
| title_fullStr |
Chemokines and chemokine receptors coordinate the inflammatory immune response in human cutaneous leishmaniasis |
| title_full_unstemmed |
Chemokines and chemokine receptors coordinate the inflammatory immune response in human cutaneous leishmaniasis |
| title_sort |
Chemokines and chemokine receptors coordinate the inflammatory immune response in human cutaneous leishmaniasis |
| author |
Campanelli, Ana Paula |
| author_facet |
Campanelli, Ana Paula Brodskyn, Claudia Ida Oliveira, Viviane Sampaio Boaventura de Silva, Claire Roselino, Ana M Costa, Jackson Mauricio Lopes Saldanha, Ana Cristina Rodrigues Freitas, Luiz Antonio Rodrigues de Oliveira, Camila Indiani de Barral Netto, Manoel Silva, João Santana da Barral, Aldina Maria Prado |
| author_role |
author |
| author2 |
Brodskyn, Claudia Ida Oliveira, Viviane Sampaio Boaventura de Silva, Claire Roselino, Ana M Costa, Jackson Mauricio Lopes Saldanha, Ana Cristina Rodrigues Freitas, Luiz Antonio Rodrigues de Oliveira, Camila Indiani de Barral Netto, Manoel Silva, João Santana da Barral, Aldina Maria Prado |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Campanelli, Ana Paula Brodskyn, Claudia Ida Oliveira, Viviane Sampaio Boaventura de Silva, Claire Roselino, Ana M Costa, Jackson Mauricio Lopes Saldanha, Ana Cristina Rodrigues Freitas, Luiz Antonio Rodrigues de Oliveira, Camila Indiani de Barral Netto, Manoel Silva, João Santana da Barral, Aldina Maria Prado |
| dc.subject.en.pt_BR.fl_str_mv |
Chemokines Cutaneous leishmaniasis Inflammation Receptores de Quimiocinas/imunologia |
| topic |
Chemokines Cutaneous leishmaniasis Inflammation Receptores de Quimiocinas/imunologia Quimiocinas/imunologia Inflamação/imunologia Leishmaniose Cutânea/imunologia Leishmaniose Cutânea/patologia Linfócitos T/metabolismo Adolescente Adulto Quimiocinas/metabolismo Criança Feminino Citometria de Fluxo Humanos Imuno-Histoquímica Leishmaniose Tegumentar Difusa/imunologia Leishmaniose Tegumentar Difusa/patologia Meia-Idade Masculino Receptores de Quimiocinas/metabolismo Linfócitos T/imunologia Adulto Jovem |
| dc.subject.decs.pt_BR.fl_str_mv |
Quimiocinas/imunologia Inflamação/imunologia Leishmaniose Cutânea/imunologia Leishmaniose Cutânea/patologia Linfócitos T/metabolismo Adolescente Adulto Quimiocinas/metabolismo Criança Feminino Citometria de Fluxo Humanos Imuno-Histoquímica Leishmaniose Tegumentar Difusa/imunologia Leishmaniose Tegumentar Difusa/patologia Meia-Idade Masculino Receptores de Quimiocinas/metabolismo Linfócitos T/imunologia Adulto Jovem |
| description |
University of São Paulo. School of Medicine of Ribeirão Preto. Department of Biochemistry and Immunology. São Paulo, SP, Brasil / University of São Paulo. Bauru Dental School. Department of Biological Sciences. São Paulo, SP. Brasil |
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2010 |
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2010 |
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2014-03-10T17:31:47Z |
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2014-03-10T17:31:47Z |
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info:eu-repo/semantics/article |
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CAMPANELLI, A. P. et al. Chemokines and chemokine receptors coordinate the inflammatory immune response in human cutaneous leishmaniasis. Human Immunology, v. 71, n. 12, p. 1220-1227, 2010. |
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https://www.arca.fiocruz.br/handle/icict/7388 |
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1879-1166 |
| dc.identifier.doi.none.fl_str_mv |
10.1016/j.humimm.2010.09.002 |
| identifier_str_mv |
CAMPANELLI, A. P. et al. Chemokines and chemokine receptors coordinate the inflammatory immune response in human cutaneous leishmaniasis. Human Immunology, v. 71, n. 12, p. 1220-1227, 2010. 1879-1166 10.1016/j.humimm.2010.09.002 |
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Elsevier |
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Elsevier |
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