Prevalence of the CCR5Δ32 mutation in Brazilian populations and cell susceptibility to HIV-1 infection

Detalhes bibliográficos
Autor(a) principal: Grimaldi, Rogério
Data de Publicação: 2002
Outros Autores: Shindo, Nice, Acosta, Angelina Xavier, Dourado, Maria Inês Costa, Brites, Carlos, Bou-Habib, Dumith Chequer, Castro, Bernardo Galvão, Carvalho, Ozenilda de Melo, Brito, Ivo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/7467
Resumo: Texto completo: acesso restrito. p. 102-104
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spelling Grimaldi, RogérioShindo, NiceAcosta, Angelina XavierDourado, Maria Inês CostaBrites, CarlosBou-Habib, Dumith ChequerCastro, Bernardo GalvãoCarvalho, Ozenilda de MeloBrito, IvoGrimaldi, RogérioShindo, NiceAcosta, Angelina XavierDourado, Maria Inês CostaBrites, CarlosBou-Habib, Dumith ChequerCastro, Bernardo GalvãoCarvalho, Ozenilda de MeloBrito, Ivo2012-12-12T17:44:58Z2002-070340-6717http://www.repositorio.ufba.br/ri/handle/ri/7467v. 111, n. 1Texto completo: acesso restrito. p. 102-104We investigated the occurrence of the CCR5Δ32 mutation in various regional ethnic groups in Brazil and tested the resistance of mutant peripheral blood mononuclear cells (PBMCs) to infection by HIV-1 in vitro. The heterozygous prevalence was 5.3% in uninfected African descendents and 8.8% in HIV-1-positive individuals (neither population had Δ32/Δ32). German descendents were 11% heterozygous and l% Δ32/Δ32. Amerindians were exclusively CCR5/CCR5. Heterozygous uninfected PBMCs showed partial resistance to R5-HIV-1 strains in vitro, but no resistance to X4 virus. HIV-1-positive CCR5/CCR5 had higher viral loads than did heterozygous cells.Submitted by Suelen Reis (suelen_suzane@hotmail.com) on 2012-12-12T17:44:58Z No. of bitstreams: 1 art%253A10.1007%252Fs00439-002-0747-x.pdf: 41622 bytes, checksum: eff4e459dafe3f7b44157c45f85857f9 (MD5)Made available in DSpace on 2012-12-12T17:44:58Z (GMT). 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dc.title.pt_BR.fl_str_mv Prevalence of the CCR5Δ32 mutation in Brazilian populations and cell susceptibility to HIV-1 infection
dc.title.alternative.pt_BR.fl_str_mv Human Genetics
title Prevalence of the CCR5Δ32 mutation in Brazilian populations and cell susceptibility to HIV-1 infection
spellingShingle Prevalence of the CCR5Δ32 mutation in Brazilian populations and cell susceptibility to HIV-1 infection
Grimaldi, Rogério
title_short Prevalence of the CCR5Δ32 mutation in Brazilian populations and cell susceptibility to HIV-1 infection
title_full Prevalence of the CCR5Δ32 mutation in Brazilian populations and cell susceptibility to HIV-1 infection
title_fullStr Prevalence of the CCR5Δ32 mutation in Brazilian populations and cell susceptibility to HIV-1 infection
title_full_unstemmed Prevalence of the CCR5Δ32 mutation in Brazilian populations and cell susceptibility to HIV-1 infection
title_sort Prevalence of the CCR5Δ32 mutation in Brazilian populations and cell susceptibility to HIV-1 infection
author Grimaldi, Rogério
author_facet Grimaldi, Rogério
Shindo, Nice
Acosta, Angelina Xavier
Dourado, Maria Inês Costa
Brites, Carlos
Bou-Habib, Dumith Chequer
Castro, Bernardo Galvão
Carvalho, Ozenilda de Melo
Brito, Ivo
author_role author
author2 Shindo, Nice
Acosta, Angelina Xavier
Dourado, Maria Inês Costa
Brites, Carlos
Bou-Habib, Dumith Chequer
Castro, Bernardo Galvão
Carvalho, Ozenilda de Melo
Brito, Ivo
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Grimaldi, Rogério
Shindo, Nice
Acosta, Angelina Xavier
Dourado, Maria Inês Costa
Brites, Carlos
Bou-Habib, Dumith Chequer
Castro, Bernardo Galvão
Carvalho, Ozenilda de Melo
Brito, Ivo
Grimaldi, Rogério
Shindo, Nice
Acosta, Angelina Xavier
Dourado, Maria Inês Costa
Brites, Carlos
Bou-Habib, Dumith Chequer
Castro, Bernardo Galvão
Carvalho, Ozenilda de Melo
Brito, Ivo
description Texto completo: acesso restrito. p. 102-104
publishDate 2002
dc.date.issued.fl_str_mv 2002-07
dc.date.accessioned.fl_str_mv 2012-12-12T17:44:58Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/7467
dc.identifier.issn.none.fl_str_mv 0340-6717
dc.identifier.number.pt_BR.fl_str_mv v. 111, n. 1
identifier_str_mv 0340-6717
v. 111, n. 1
url http://www.repositorio.ufba.br/ri/handle/ri/7467
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1007/s00439-002-0747-x
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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