Study of the CCR5-m303 mutation in three different ethnic groups from Brazil

Detalhes bibliográficos
Autor(a) principal: Grimaldi, Rogério
Data de Publicação: 2005
Outros Autores: Acosta, Angelina Xavier, Oliveira, Fernando Cézar Cabral, Brites, Carlos, Castro, Bernardo Galvão
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/2622
Resumo: p.214-217
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spelling Grimaldi, RogérioAcosta, Angelina XavierOliveira, Fernando Cézar CabralBrites, CarlosCastro, Bernardo GalvãoGrimaldi, RogérioAcosta, Angelina XavierOliveira, Fernando Cézar CabralBrites, CarlosCastro, Bernardo Galvão2011-09-08T19:44:28Z2011-09-08T19:44:28Z200515-4757http://www.repositorio.ufba.br/ri/handle/ri/262228(2):214-217p.214-217The main coreceptor gene involved in HIV-1 infection is CCR5 b chemokine receptor gene for which several mutations have been described, some of which have correlated with HIV-1 infection, acquired immune deficiency syndrome (AIDS), or both. Deletion of 32bp in the CCR5 gene (D32) has been shown to confer resistance to infection by HIV-1 R5 strains. Another mutation, characterized by a thymine to adenine (T to A) nucleotide substitution at position 303 (m303), has shown the same effects as the D32 mutation, with previous studies having shown that the allele frequency of the CCR5-m303 mutation is 0.014 in African-American and 0.007 in French populations. The Brazilian population is known to be genetically diverse, because of which we investigated the allele frequency of the CCR5-m303 mutation in three different Brazilian ethnic groups containing individuals who were not infected with HIV-1 and also in a cohort of HIV-1 long-term non-progressors. We used the polymerase chain reaction (PCR) and HincII restriction fragment length polymorphisms (RFLP) to investigate these populations and found that none of the 566 individuals examined the mutant CCR5-m303 allele. These results are in accordance with the previously reported allelic frequencies for African-American and Caucasian populations and may reflect the real prevalence of the m303 mutation in Brazil.Submitted by Rigaud Andréa (andrearigaud16@yahoo.com.br) on 2011-09-08T19:44:28Z No. of bitstreams: 1 a06v28n2.pdf: 72260 bytes, checksum: 7d59f8849356d428c8fcd85fce8353ff (MD5)Made available in DSpace on 2011-09-08T19:44:28Z (GMT). No. of bitstreams: 1 a06v28n2.pdf: 72260 bytes, checksum: 7d59f8849356d428c8fcd85fce8353ff (MD5) Previous issue date: 2005São pauloCCR5 geneBrazilian populationsm303 frequencyHIV-1Study of the CCR5-m303 mutation in three different ethnic groups from BrazilGenetics and Molecular Biologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAinfo:eu-repo/semantics/openAccessORIGINALa06v28n2.pdfa06v28n2.pdfapplication/pdf72260https://repositorio.ufba.br/bitstream/ri/2622/1/a06v28n2.pdf7d59f8849356d428c8fcd85fce8353ffMD51LICENSElicense.txtlicense.txttext/plain1906https://repositorio.ufba.br/bitstream/ri/2622/2/license.txt3952d45f4ed16021b001847e1627e2c9MD52TEXTa06v28n2.pdf.txta06v28n2.pdf.txtExtracted texttext/plain17059https://repositorio.ufba.br/bitstream/ri/2622/3/a06v28n2.pdf.txtabdf6973a5c7e9e0d400b220096454f6MD53ri/26222022-07-05 14:02:53.471oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:02:53Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Study of the CCR5-m303 mutation in three different ethnic groups from Brazil
dc.title.alternative.pt_BR.fl_str_mv Genetics and Molecular Biology
title Study of the CCR5-m303 mutation in three different ethnic groups from Brazil
spellingShingle Study of the CCR5-m303 mutation in three different ethnic groups from Brazil
Grimaldi, Rogério
CCR5 gene
Brazilian populations
m303 frequency
HIV-1
title_short Study of the CCR5-m303 mutation in three different ethnic groups from Brazil
title_full Study of the CCR5-m303 mutation in three different ethnic groups from Brazil
title_fullStr Study of the CCR5-m303 mutation in three different ethnic groups from Brazil
title_full_unstemmed Study of the CCR5-m303 mutation in three different ethnic groups from Brazil
title_sort Study of the CCR5-m303 mutation in three different ethnic groups from Brazil
author Grimaldi, Rogério
author_facet Grimaldi, Rogério
Acosta, Angelina Xavier
Oliveira, Fernando Cézar Cabral
Brites, Carlos
Castro, Bernardo Galvão
author_role author
author2 Acosta, Angelina Xavier
Oliveira, Fernando Cézar Cabral
Brites, Carlos
Castro, Bernardo Galvão
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Grimaldi, Rogério
Acosta, Angelina Xavier
Oliveira, Fernando Cézar Cabral
Brites, Carlos
Castro, Bernardo Galvão
Grimaldi, Rogério
Acosta, Angelina Xavier
Oliveira, Fernando Cézar Cabral
Brites, Carlos
Castro, Bernardo Galvão
dc.subject.por.fl_str_mv CCR5 gene
Brazilian populations
m303 frequency
HIV-1
topic CCR5 gene
Brazilian populations
m303 frequency
HIV-1
description p.214-217
publishDate 2005
dc.date.issued.fl_str_mv 2005
dc.date.accessioned.fl_str_mv 2011-09-08T19:44:28Z
dc.date.available.fl_str_mv 2011-09-08T19:44:28Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/2622
dc.identifier.issn.none.fl_str_mv 15-4757
dc.identifier.number.pt_BR.fl_str_mv 28(2):214-217
identifier_str_mv 15-4757
28(2):214-217
url http://www.repositorio.ufba.br/ri/handle/ri/2622
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
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collection Repositório Institucional da UFBA
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