Study of the CCR5-m303 mutation in three different ethnic groups from Brazil

Detalhes bibliográficos
Autor(a) principal: Grimaldi, Rogério
Data de Publicação: 2005
Outros Autores: Acosta, Angelina Xavier, Oliveira Filho, Fernando Cézar Cabral de, Alves, Carlos Roberto Brites, Castro Filho, Bernardo Galvão
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/6213
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil / Fundação Bahiana para o Desenvolvimento das Ciências. Escola Bahiana de Medicina e Saúde Pública. Salvador, Bahia, Brasil.
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spelling Grimaldi, RogérioAcosta, Angelina XavierOliveira Filho, Fernando Cézar Cabral deAlves, Carlos Roberto BritesCastro Filho, Bernardo Galvão2013-01-17T20:56:02Z2013-01-17T20:56:02Z2005GRIMALDI, R. et al. Study of the CCR5-m303 mutation in three different ethnic groups. Genetics and Molecular Biology, v. 28, n. 2, p. 214-217, 2005.1415-4757https://www.arca.fiocruz.br/handle/icict/6213engStudy of the CCR5-m303 mutation in three different ethnic groups from Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil / Fundação Bahiana para o Desenvolvimento das Ciências. Escola Bahiana de Medicina e Saúde Pública. Salvador, Bahia, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Departamento de Pediatria. Salvador, Bahia, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, BrasilUniversidade Federal da Bahia. Faculdade de Medicina. Departamento de Virologia. Salvador, Bahia, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil / Fundação Bahiana para o Desenvolvimento das Ciências. Escola Bahiana de Medicina e Saúde Pública. Salvador, Bahia, BrasilAbstract The main coreceptor gene involved in HIV-1 infection is CCR5 β chemokine receptor gene for which several mutations have been described, some of which have correlated with HIV-1 infection, acquired immune deficiency syndrome (AIDS), or both. Deletion of 32bp in the CCR5 gene (Δ32) has been shown to confer resistance to infection by HIV-1 R5 strains. Another mutation, characterized by a thymine to adenine (T to A) nucleotide substitution at position 303 (m303), has shown the same effects as the Δ32 mutation, with previous studies having shown that the allele frequency of the CCR5-m303 mutation is 0.014 in African-American and 0.007 in French populations. The Brazilian population is known to be genetically diverse, because of which we investigated the allele frequency of the CCR5-m303 mutation in three different Brazilian ethnic groups containing individuals who were not infected with HIV-1 and also in a cohort of HIV-1 long-term non-progressors. We used the polymerase chain reaction (PCR) and HincII restriction fragment length polymorphisms (RFLP) to investigate these populations and found that none of the 566 individuals examined the mutant CCR5-m303 allele. These results are in accordance with the previously reported allelic frequencies for African-American and Caucasian populations and may reflect the real prevalence of the m303 mutation in Brazil.CCR5 geneM303 frequencyBrazilian populationsHIV-1info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALGrimaldi, Rogerio Study of the CCR5....pdfGrimaldi, Rogerio Study of the CCR5....pdfapplication/pdf72260https://www.arca.fiocruz.br/bitstream/icict/6213/1/Grimaldi%2c%20Rogerio%20Study%20of%20the%20CCR5....pdf7d59f8849356d428c8fcd85fce8353ffMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/6213/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTGrimaldi, Rogerio Study of the CCR5....pdf.txtGrimaldi, Rogerio Study of the CCR5....pdf.txtExtracted texttext/plain17128https://www.arca.fiocruz.br/bitstream/icict/6213/5/Grimaldi%2c%20Rogerio%20Study%20of%20the%20CCR5....pdf.txt877da097ff63ff1e474acd3acf8948feMD55THUMBNAILGrimaldi, Rogerio Study of the CCR5....pdf.jpgGrimaldi, Rogerio Study of the CCR5....pdf.jpgGenerated Thumbnailimage/jpeg1905https://www.arca.fiocruz.br/bitstream/icict/6213/4/Grimaldi%2c%20Rogerio%20Study%20of%20the%20CCR5....pdf.jpg007fbbd743507349866d347d81434938MD54icict/62132023-03-15 14:33:26.214oai:www.arca.fiocruz.br:icict/6213TElDRU7Dh0EgREUgRElTVFJJQlVJw4fDg08gTsODTy1FWENMVVNJVkEKCkFvIGNvbmNvcmRhciBlIGFjZWl0YXIgZXN0YSBsaWNlbsOnYSB2b2PDqiAoYXV0b3Igb3UgZGV0ZW50b3IgZG9zIGRpcmVpdG9zIGF1dG9yYWlzKToKCmEpIERlY2xhcmEgcXVlIGNvbmhlY2UgYSBwb2zDrXRpY2EgZGUgY29weXJpZ2h0IGRhIGVkaXRvcmEgZG8gc2V1IGRvY3VtZW50by4KCmIpIERlY2xhcmEgcXVlIGNvbmhlY2UgZSBhY2VpdGEgYXMgRGlyZXRyaXplcyBwYXJhIG8gUmVwb3NpdMOzcmlvIEluc3RpdHVjaW9uYWwgZGEgRnVuZGHDp8OjbyBPc3dhbGRvIENydXogKEZJT0NSVVopLgoKYykgQ29uY2VkZSDDoCBGSU9DUlVaIG8gZGlyZWl0byBuw6NvLWV4Y2x1c2l2byBkZSBhcnF1aXZhciwgcmVwcm9kdXppciwgY29udmVydGVyIChjb21vIGRlZmluaWRvIGEgc2VndWlyKSwgY29tdW5pY2FyCiAKZS9vdSBkaXN0cmlidWlyIG5vIFJlcG9zaXTDs3JpbyBkYSBGSU9DUlVaLCBvIGRvY3VtZW50byBlbnRyZWd1ZSAoaW5jbHVpbmRvIG8gcmVzdW1vL2Fic3RyYWN0KSBlbSBmb3JtYXRvIGRpZ2l0YWwgb3UgCgpwb3IgcXVhbHF1ZXIgb3V0cm8gbWVpby4KCmQpIERlY2xhcmEgcXVlIGF1dG9yaXphIGEgRklPQ1JVWiBhIGFycXVpdmFyIG1haXMgZGUgdW1hIGPDs3BpYSBkZXN0ZSBkb2N1bWVudG8gZSBjb252ZXJ0w6otbG8sIHNlbSBhbHRlcmFyIG8gc2V1IGNvbnRlw7pkbywgCgpwYXJhIHF1YWxxdWVyIGZvcm1hdG8gZGUgYXJxdWl2bywgbWVpbyBvdSBzdXBvcnRlLCBwYXJhIGVmZWl0b3MgZGUgc2VndXJhbsOnYSwgcHJlc2VydmHDp8OjbyAoYmFja3VwKSBlIGFjZXNzby4KCmUpIERlY2xhcmEgcXVlIG8gZG9jdW1lbnRvIHN1Ym1ldGlkbyDDqSBvIHNldSB0cmFiYWxobyBvcmlnaW5hbCwgZSBxdWUgZGV0w6ltIG8gZGlyZWl0byBkZSBjb25jZWRlciBhIHRlcmNlaXJvcyBvcyBkaXJlaXRvcyAKCmNvbnRpZG9zIG5lc3RhIGxpY2Vuw6dhLiBEZWNsYXJhIHRhbWLDqW0gcXVlIGEgZW50cmVnYSBkbyBkb2N1bWVudG8gbsOjbyBpbmZyaW5nZSBvcyBkaXJlaXRvcyBkZSBxdWFscXVlciBvdXRyYSBwZXNzb2Egb3UgZW50aWRhZGUuCgpmKSBEZWNsYXJhIHF1ZSwgbm8gY2FzbyBkbyBkb2N1bWVudG8gc3VibWV0aWRvIGNvbnRlciBtYXRlcmlhbCBkbyBxdWFsIG7Do28gZGV0w6ltIG9zIGRpcmVpdG9zIGRlIGF1dG9yLCBvYnRldmUgYSBhdXRvcml6YcOnw6NvIAoKaXJyZXN0cml0YSBkbyByZXNwZWN0aXZvIGRldGVudG9yIGRlc3NlcyBkaXJlaXRvcywgcGFyYSBjZWRlciBhIEZJT0NSVVogb3MgZGlyZWl0b3MgcmVxdWVyaWRvcyBwb3IgZXN0YSBMaWNlbsOnYSBlIGF1dG9yaXphciBhIAoKdXRpbGl6w6EtbG9zIGxlZ2FsbWVudGUuIERlY2xhcmEgdGFtYsOpbSBxdWUgZXNzZSBtYXRlcmlhbCBjdWpvcyBkaXJlaXRvcyBzw6NvIGRlIHRlcmNlaXJvcyBlc3TDoSBjbGFyYW1lbnRlIGlkZW50aWZpY2FkbyBlIHJlY29uaGVjaWRvIAoKbm8gdGV4dG8gb3UgY29udGXDumRvIGRvIGRvY3VtZW50byBlbnRyZWd1ZS4KCmcpIFNFIE8gRE9DVU1FTlRPIEVOVFJFR1VFIMOJIEJBU0VBRE8gRU0gVFJBQkFMSE8gRklOQU5DSUFETyBPVSBBUE9JQURPIFBPUiBPVVRSQSBJTlNUSVRVScOHw4NPIFFVRSBOw4NPIEEgRklPQ1JVWiwgREVDTEFSQSBRVUUgQ1VNUFJJVSAKClFVQUlTUVVFUiBPQlJJR0HDh8OVRVMgRVhJR0lEQVMgUEVMTyBSRVNQRUNUSVZPIENPTlRSQVRPIE9VIEFDT1JETy4gQSBGSU9DUlVaIGlkZW50aWZpY2Fyw6EgY2xhcmFtZW50ZSBvKHMpIG5vbWUocykgZG8ocykgYXV0b3IoZXMpIGRvcyAKCmRpcmVpdG9zIGRvIGRvY3VtZW50byBlbnRyZWd1ZSBlIG7Do28gZmFyw6EgcXVhbHF1ZXIgYWx0ZXJhw6fDo28sIHBhcmEgYWzDqW0gZG8gcHJldmlzdG8gbmEgYWzDrW5lYSBjKS4KRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:26Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Study of the CCR5-m303 mutation in three different ethnic groups from Brazil
title Study of the CCR5-m303 mutation in three different ethnic groups from Brazil
spellingShingle Study of the CCR5-m303 mutation in three different ethnic groups from Brazil
Grimaldi, Rogério
CCR5 gene
M303 frequency
Brazilian populations
HIV-1
title_short Study of the CCR5-m303 mutation in three different ethnic groups from Brazil
title_full Study of the CCR5-m303 mutation in three different ethnic groups from Brazil
title_fullStr Study of the CCR5-m303 mutation in three different ethnic groups from Brazil
title_full_unstemmed Study of the CCR5-m303 mutation in three different ethnic groups from Brazil
title_sort Study of the CCR5-m303 mutation in three different ethnic groups from Brazil
author Grimaldi, Rogério
author_facet Grimaldi, Rogério
Acosta, Angelina Xavier
Oliveira Filho, Fernando Cézar Cabral de
Alves, Carlos Roberto Brites
Castro Filho, Bernardo Galvão
author_role author
author2 Acosta, Angelina Xavier
Oliveira Filho, Fernando Cézar Cabral de
Alves, Carlos Roberto Brites
Castro Filho, Bernardo Galvão
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Grimaldi, Rogério
Acosta, Angelina Xavier
Oliveira Filho, Fernando Cézar Cabral de
Alves, Carlos Roberto Brites
Castro Filho, Bernardo Galvão
dc.subject.en.pt_BR.fl_str_mv CCR5 gene
M303 frequency
Brazilian populations
HIV-1
topic CCR5 gene
M303 frequency
Brazilian populations
HIV-1
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil / Fundação Bahiana para o Desenvolvimento das Ciências. Escola Bahiana de Medicina e Saúde Pública. Salvador, Bahia, Brasil.
publishDate 2005
dc.date.issued.fl_str_mv 2005
dc.date.accessioned.fl_str_mv 2013-01-17T20:56:02Z
dc.date.available.fl_str_mv 2013-01-17T20:56:02Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GRIMALDI, R. et al. Study of the CCR5-m303 mutation in three different ethnic groups. Genetics and Molecular Biology, v. 28, n. 2, p. 214-217, 2005.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/6213
dc.identifier.issn.none.fl_str_mv 1415-4757
identifier_str_mv GRIMALDI, R. et al. Study of the CCR5-m303 mutation in three different ethnic groups. Genetics and Molecular Biology, v. 28, n. 2, p. 214-217, 2005.
1415-4757
url https://www.arca.fiocruz.br/handle/icict/6213
dc.language.iso.fl_str_mv eng
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