Increased concentrations of IL-18 and uric acid in sickle cell anemia: Contribution of hemolysis, endothelial activation and the inflammasome

Detalhes bibliográficos
Autor(a) principal: Cerqueira, Bruno A. V.
Data de Publicação: 2011
Outros Autores: Gonçalves, Marilda Souza, Vilas Boas, Wendell, Zanette, Angela Maria Dias, Reis, Mitermayer Galvão dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/5317
Resumo: texto completo: acesso restrito. p.471–476.
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spelling Cerqueira, Bruno A. V.Gonçalves, Marilda SouzaVilas Boas, WendellZanette, Angela Maria DiasReis, Mitermayer Galvão dosCerqueira, Bruno A. V.Gonçalves, Marilda SouzaVilas Boas, WendellZanette, Angela Maria DiasReis, Mitermayer Galvão dos2012-02-07T19:02:00Z20111096-0023http://www.repositorio.ufba.br/ri/handle/ri/5317v. 56.texto completo: acesso restrito. p.471–476.Sickle cell anemia (SCA) is a common, severe monogenetic disorder characterized by chronic hemolysis, frequent infections, a chronic inflammatory state and recurrent occlusions of the microcirculation, result- ing in painful crises, organ damage and premature death. This study evaluated associations between serum levels of IL-18, uric acid, hemolytic markers, and inflammatory molecules in SCA patients. A cross-sectional study was performed including 45 SCA patients (median age of 20.5 years) without gen- eral symptoms and who had not undergone blood transfusions. Inclusion criteria for the steady-state SCA patients were the absence of hospitalization and the absence of infections. Interleukin-18 and uric acid levels were correlated closely with markers of hemolysis, endothelial dysfunction and others cytokines levels. These findings suggest probable influences of IL-18 and uric acid in the pathophysiology of vascu- lar occlusion in SCA. Additional studies should be performed to characterize similar prognosis markers and possible therapeutic targets.Submitted by Ana Valéria de Jesus Moura (anavaleria_131@hotmail.com) on 2012-02-07T19:02:00Z No. of bitstreams: 1 __pdn.sciencedirect.com_....0-S1043466611006764-main.pdf: 270192 bytes, checksum: 28be38214d9caa6a903a59bab16e78cd (MD5)Made available in DSpace on 2012-02-07T19:02:00Z (GMT). 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dc.title.pt_BR.fl_str_mv Increased concentrations of IL-18 and uric acid in sickle cell anemia: Contribution of hemolysis, endothelial activation and the inflammasome
dc.title.alternative.pt_BR.fl_str_mv Cytokine
title Increased concentrations of IL-18 and uric acid in sickle cell anemia: Contribution of hemolysis, endothelial activation and the inflammasome
spellingShingle Increased concentrations of IL-18 and uric acid in sickle cell anemia: Contribution of hemolysis, endothelial activation and the inflammasome
Cerqueira, Bruno A. V.
Sickle cell anemia
Cytokine
Inflammation
title_short Increased concentrations of IL-18 and uric acid in sickle cell anemia: Contribution of hemolysis, endothelial activation and the inflammasome
title_full Increased concentrations of IL-18 and uric acid in sickle cell anemia: Contribution of hemolysis, endothelial activation and the inflammasome
title_fullStr Increased concentrations of IL-18 and uric acid in sickle cell anemia: Contribution of hemolysis, endothelial activation and the inflammasome
title_full_unstemmed Increased concentrations of IL-18 and uric acid in sickle cell anemia: Contribution of hemolysis, endothelial activation and the inflammasome
title_sort Increased concentrations of IL-18 and uric acid in sickle cell anemia: Contribution of hemolysis, endothelial activation and the inflammasome
author Cerqueira, Bruno A. V.
author_facet Cerqueira, Bruno A. V.
Gonçalves, Marilda Souza
Vilas Boas, Wendell
Zanette, Angela Maria Dias
Reis, Mitermayer Galvão dos
author_role author
author2 Gonçalves, Marilda Souza
Vilas Boas, Wendell
Zanette, Angela Maria Dias
Reis, Mitermayer Galvão dos
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Cerqueira, Bruno A. V.
Gonçalves, Marilda Souza
Vilas Boas, Wendell
Zanette, Angela Maria Dias
Reis, Mitermayer Galvão dos
Cerqueira, Bruno A. V.
Gonçalves, Marilda Souza
Vilas Boas, Wendell
Zanette, Angela Maria Dias
Reis, Mitermayer Galvão dos
dc.subject.por.fl_str_mv Sickle cell anemia
Cytokine
Inflammation
topic Sickle cell anemia
Cytokine
Inflammation
description texto completo: acesso restrito. p.471–476.
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2012-02-07T19:02:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/5317
dc.identifier.issn.none.fl_str_mv 1096-0023
dc.identifier.number.pt_BR.fl_str_mv v. 56.
identifier_str_mv 1096-0023
v. 56.
url http://www.repositorio.ufba.br/ri/handle/ri/5317
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv doi:10.1016/j.cyto.2011.08.013
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
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institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
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