Neospora caninum: Infection induced IL-10 overexpression in rat astrocytes in vitro
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2006 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/12792 |
Resumo: | Texto completo: acesso restrito. p.193–197 |
| id |
UFBA-2_523e2d596dde10fe0b3b3f5255cb0c32 |
|---|---|
| oai_identifier_str |
oai:repositorio.ufba.br:ri/12792 |
| network_acronym_str |
UFBA-2 |
| network_name_str |
Repositório Institucional da UFBA |
| repository_id_str |
1932 |
| spelling |
Pinheiro, A. M.Costa, Silvia LimaFreire, S. M.Nascimento, Roberto José MeyerAlmeida, Maria Angela Ornelas deTardy, Marcienne BlochEl-Bachá, Ramon dos SantosCosta, Maria de Fátima DiasPinheiro, A. M.Costa, Silvia LimaFreire, S. M.Nascimento, Roberto José MeyerAlmeida, Maria Angela Ornelas deTardy, Marcienne BlochEl-Bachá, Ramon dos SantosCosta, Maria de Fátima Dias2013-09-02T15:24:40Z20060014-4894http://www.repositorio.ufba.br/ri/handle/ri/12792v.112 n. 3Texto completo: acesso restrito. p.193–197The effect of Neospora caninum, a parasite that causes abortion and neuromuscular changes, has been investigated on a major population of neural cells, the astrocytes. Highly enriched astroglial primary cultures obtained from neonatal rats were infected after 21 days of culture. Astroglial reactivity, IL-10 and IFN-γ expression, and cell viability (lactate dehydrogenase activity, metabolization of tetrazolium salt, and trypan blue exclusion assay) have been investigated after 24 and 72 h of infection. Astroglial hypertrophy, gliofilament reorganization, metabolic changes suggesting hypoxia and a strong IL-10 release have been observed in the infected cells. These results show that neural cells are targets for the parasite and that astrocytes may contribute to the CNS immune response to the parasite.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2013-08-29T16:08:01Z No. of bitstreams: 1 1-s2.0-S0014489405002791-main.pdf: 301544 bytes, checksum: e6fd21c4145ac6f1edcc75fe0a4c36dc (MD5)Approved for entry into archive by Patricia Barroso(pbarroso@ufba.br) on 2013-09-02T15:24:40Z (GMT) No. of bitstreams: 1 1-s2.0-S0014489405002791-main.pdf: 301544 bytes, checksum: e6fd21c4145ac6f1edcc75fe0a4c36dc (MD5)Made available in DSpace on 2013-09-02T15:24:40Z (GMT). No. of bitstreams: 1 1-s2.0-S0014489405002791-main.pdf: 301544 bytes, checksum: e6fd21c4145ac6f1edcc75fe0a4c36dc (MD5) Previous issue date: 2006http://dx.doi.org.ez10.periodicos.capes.gov.br/10.1016/j.exppara.2005.10.008reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBANeospora caninumAstrocytesImmune responseNeospora caninum: Infection induced IL-10 overexpression in rat astrocytes in vitroExperimental Parasitologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINAL1-s2.0-S0014489405002791-main.pdf1-s2.0-S0014489405002791-main.pdfapplication/pdf301544https://repositorio.ufba.br/bitstream/ri/12792/1/1-s2.0-S0014489405002791-main.pdfe6fd21c4145ac6f1edcc75fe0a4c36dcMD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/12792/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXT1-s2.0-S0014489405002791-main.pdf.txt1-s2.0-S0014489405002791-main.pdf.txtExtracted texttext/plain19287https://repositorio.ufba.br/bitstream/ri/12792/3/1-s2.0-S0014489405002791-main.pdf.txt9a29dbaa96ce6e78cca5705a761e50f3MD53ri/127922022-07-05 14:02:50.861oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:02:50Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Neospora caninum: Infection induced IL-10 overexpression in rat astrocytes in vitro |
| dc.title.alternative.pt_BR.fl_str_mv |
Experimental Parasitology |
| title |
Neospora caninum: Infection induced IL-10 overexpression in rat astrocytes in vitro |
| spellingShingle |
Neospora caninum: Infection induced IL-10 overexpression in rat astrocytes in vitro Pinheiro, A. M. Neospora caninum Astrocytes Immune response |
| title_short |
Neospora caninum: Infection induced IL-10 overexpression in rat astrocytes in vitro |
| title_full |
Neospora caninum: Infection induced IL-10 overexpression in rat astrocytes in vitro |
| title_fullStr |
Neospora caninum: Infection induced IL-10 overexpression in rat astrocytes in vitro |
| title_full_unstemmed |
Neospora caninum: Infection induced IL-10 overexpression in rat astrocytes in vitro |
| title_sort |
Neospora caninum: Infection induced IL-10 overexpression in rat astrocytes in vitro |
| author |
Pinheiro, A. M. |
| author_facet |
Pinheiro, A. M. Costa, Silvia Lima Freire, S. M. Nascimento, Roberto José Meyer Almeida, Maria Angela Ornelas de Tardy, Marcienne Bloch El-Bachá, Ramon dos Santos Costa, Maria de Fátima Dias |
| author_role |
author |
| author2 |
Costa, Silvia Lima Freire, S. M. Nascimento, Roberto José Meyer Almeida, Maria Angela Ornelas de Tardy, Marcienne Bloch El-Bachá, Ramon dos Santos Costa, Maria de Fátima Dias |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Pinheiro, A. M. Costa, Silvia Lima Freire, S. M. Nascimento, Roberto José Meyer Almeida, Maria Angela Ornelas de Tardy, Marcienne Bloch El-Bachá, Ramon dos Santos Costa, Maria de Fátima Dias Pinheiro, A. M. Costa, Silvia Lima Freire, S. M. Nascimento, Roberto José Meyer Almeida, Maria Angela Ornelas de Tardy, Marcienne Bloch El-Bachá, Ramon dos Santos Costa, Maria de Fátima Dias |
| dc.subject.por.fl_str_mv |
Neospora caninum Astrocytes Immune response |
| topic |
Neospora caninum Astrocytes Immune response |
| description |
Texto completo: acesso restrito. p.193–197 |
| publishDate |
2006 |
| dc.date.issued.fl_str_mv |
2006 |
| dc.date.accessioned.fl_str_mv |
2013-09-02T15:24:40Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://www.repositorio.ufba.br/ri/handle/ri/12792 |
| dc.identifier.issn.none.fl_str_mv |
0014-4894 |
| dc.identifier.number.pt_BR.fl_str_mv |
v.112 n. 3 |
| identifier_str_mv |
0014-4894 v.112 n. 3 |
| url |
http://www.repositorio.ufba.br/ri/handle/ri/12792 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.source.pt_BR.fl_str_mv |
http://dx.doi.org.ez10.periodicos.capes.gov.br/10.1016/j.exppara.2005.10.008 |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFBA instname:Universidade Federal da Bahia (UFBA) instacron:UFBA |
| instname_str |
Universidade Federal da Bahia (UFBA) |
| instacron_str |
UFBA |
| institution |
UFBA |
| reponame_str |
Repositório Institucional da UFBA |
| collection |
Repositório Institucional da UFBA |
| bitstream.url.fl_str_mv |
https://repositorio.ufba.br/bitstream/ri/12792/1/1-s2.0-S0014489405002791-main.pdf https://repositorio.ufba.br/bitstream/ri/12792/2/license.txt https://repositorio.ufba.br/bitstream/ri/12792/3/1-s2.0-S0014489405002791-main.pdf.txt |
| bitstream.checksum.fl_str_mv |
e6fd21c4145ac6f1edcc75fe0a4c36dc 1b89a9a0548218172d7c829f87a0eab9 9a29dbaa96ce6e78cca5705a761e50f3 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA) |
| repository.mail.fl_str_mv |
|
| _version_ |
1801502515282313216 |