Neospora caninum: Early immune response of rat mixed glial cultures after tachyzoites infection

Detalhes bibliográficos
Autor(a) principal: Pinheiro, A. M.
Data de Publicação: 2010
Outros Autores: Costa, Silvia Lima, Freire, S. M., Ribeiro, C. S. O., Tardy, Marcienne Bloch, El-Bachá, Ramon dos Santos, Costa, Maria de Fátima Dias
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/5842
Resumo: Trabalho completo: acesso restrito, p.442–447
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spelling Pinheiro, A. M.Costa, Silvia LimaFreire, S. M.Ribeiro, C. S. O.Tardy, Marcienne BlochEl-Bachá, Ramon dos SantosCosta, Maria de Fátima DiasPinheiro, A. M.Costa, Silvia LimaFreire, S. M.Ribeiro, C. S. O.Tardy, Marcienne BlochEl-Bachá, Ramon dos SantosCosta, Maria de Fátima Dias2012-05-11T19:04:23Z2010-040014-4894http://www.repositorio.ufba.br/ri/handle/ri/5842v.124, n. 4Trabalho completo: acesso restrito, p.442–447Neospora caninum causes neurologic disease in dogs and abortion in cattle. Little is known about the immune response of the CNS against this protozoan. The aim of this study was to evaluate production of IL-6, IL-10, TNF-α, IFN-γ, and NO in rat mixed glial cell cultures infected by N. caninum. IFN-γ was not observed. The mean cytokine released after 24 and 72 h of infection were 3.8 ± 0.6 and 3.7 ± 0.6 pg TNF-α/mg protein and 2.7 ± 0.69 and 4.1 ± 0.64 pg IL-10/mg protein, respectively, and more than 8.0 pg IL-6/mg protein for both time points. NO levels increased 24 h post-infection (2.3 ± 0.8 pg/mg protein) until 72 h (4.2 ± 1.1 pg/mg protein) and the number of tachyzoites reduced with the time. Our results show high levels of regulatory cytokines that may suppress the harmful effects of IFN-γ; high levels of TNF-α and NO may represent an effective response by infected glial cells against N. caninum.Submitted by Bruna Lessa (lessbruna@gmail.com) on 2012-05-11T19:04:23Z No. of bitstreams: 1 (10)1-s2.0-S0014489409003543-main.pdf: 482275 bytes, checksum: 6326717d663b6292a95b2844441461b6 (MD5)Made available in DSpace on 2012-05-11T19:04:23Z (GMT). No. of bitstreams: 1 (10)1-s2.0-S0014489409003543-main.pdf: 482275 bytes, checksum: 6326717d663b6292a95b2844441461b6 (MD5) Previous issue date: 2010-04Elsevierhttp://dx.doi.org/10.1016/j.exppara.2009.12.018reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBANeospora caninumImmune responseCNSCytokinesNeospora caninum: Early immune response of rat mixed glial cultures after tachyzoites infectionExperimental Parasitologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessLICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/5842/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52ORIGINAL(10)1-s2.0-S0014489409003543-main.pdf(10)1-s2.0-S0014489409003543-main.pdfapplication/pdf482275https://repositorio.ufba.br/bitstream/ri/5842/1/%2810%291-s2.0-S0014489409003543-main.pdf6326717d663b6292a95b2844441461b6MD51TEXT(10)1-s2.0-S0014489409003543-main.pdf.txt(10)1-s2.0-S0014489409003543-main.pdf.txtExtracted texttext/plain32881https://repositorio.ufba.br/bitstream/ri/5842/3/%2810%291-s2.0-S0014489409003543-main.pdf.txt483723694df8d608a8360050a600bd6eMD53ri/58422022-07-05 14:03:21.771oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:21Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Neospora caninum: Early immune response of rat mixed glial cultures after tachyzoites infection
dc.title.alternative.pt_BR.fl_str_mv Experimental Parasitology
title Neospora caninum: Early immune response of rat mixed glial cultures after tachyzoites infection
spellingShingle Neospora caninum: Early immune response of rat mixed glial cultures after tachyzoites infection
Pinheiro, A. M.
Neospora caninum
Immune response
CNS
Cytokines
title_short Neospora caninum: Early immune response of rat mixed glial cultures after tachyzoites infection
title_full Neospora caninum: Early immune response of rat mixed glial cultures after tachyzoites infection
title_fullStr Neospora caninum: Early immune response of rat mixed glial cultures after tachyzoites infection
title_full_unstemmed Neospora caninum: Early immune response of rat mixed glial cultures after tachyzoites infection
title_sort Neospora caninum: Early immune response of rat mixed glial cultures after tachyzoites infection
author Pinheiro, A. M.
author_facet Pinheiro, A. M.
Costa, Silvia Lima
Freire, S. M.
Ribeiro, C. S. O.
Tardy, Marcienne Bloch
El-Bachá, Ramon dos Santos
Costa, Maria de Fátima Dias
author_role author
author2 Costa, Silvia Lima
Freire, S. M.
Ribeiro, C. S. O.
Tardy, Marcienne Bloch
El-Bachá, Ramon dos Santos
Costa, Maria de Fátima Dias
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Pinheiro, A. M.
Costa, Silvia Lima
Freire, S. M.
Ribeiro, C. S. O.
Tardy, Marcienne Bloch
El-Bachá, Ramon dos Santos
Costa, Maria de Fátima Dias
Pinheiro, A. M.
Costa, Silvia Lima
Freire, S. M.
Ribeiro, C. S. O.
Tardy, Marcienne Bloch
El-Bachá, Ramon dos Santos
Costa, Maria de Fátima Dias
dc.subject.por.fl_str_mv Neospora caninum
Immune response
CNS
Cytokines
topic Neospora caninum
Immune response
CNS
Cytokines
description Trabalho completo: acesso restrito, p.442–447
publishDate 2010
dc.date.issued.fl_str_mv 2010-04
dc.date.accessioned.fl_str_mv 2012-05-11T19:04:23Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/5842
dc.identifier.issn.none.fl_str_mv 0014-4894
dc.identifier.number.pt_BR.fl_str_mv v.124, n. 4
identifier_str_mv 0014-4894
v.124, n. 4
url http://www.repositorio.ufba.br/ri/handle/ri/5842
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1016/j.exppara.2009.12.018
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
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