Evaluation of drug–drug interaction screening software combined with pharmacist intervention

Detalhes bibliográficos
Autor(a) principal: Prado, Nília M.
Data de Publicação: 2012
Outros Autores: Belo, Najara de Oliveira, Moura, Cristiano Soares de, Acurcio, Francisco de Assis
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/15343
Resumo: Texto completo: acesso restrito. p. 547-552
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spelling Prado, Nília M.Belo, Najara de OliveiraMoura, Cristiano Soares deAcurcio, Francisco de AssisPrado, Nília M.Belo, Najara de OliveiraMoura, Cristiano Soares deAcurcio, Francisco de Assis2014-07-29T14:35:24Z20122210-7703http://repositorio.ufba.br/ri/handle/ri/15343v. 34, n. 4Texto completo: acesso restrito. p. 547-552Background Drug-drug interactions (DDI) in hospitalized patients are highly prevalent and an important source of adverse drug reactions. DI computerized screening system can prevent the occurrence of some of these events. Objective To evaluate the impact of drug–drug interaction (DDI) screening software combined with active intervention in preventing drug interactions. Setting The study was conducted at General Hospital of Vitória da Conquista (HGVC), Brazil. Method A quasi-experimental study was used to evaluate the impact of IM-Pharma, a locally developed drug–drug interaction screening system, coupled with pharmacist intervention on adverse drug events in the hospital setting. Main outcome measure The proportion of patients co-prescribed two interacting drugs were measured in two phases, prior the implementation of IM-Pharma and during the intervention period. DDI rates per 100 patient days were calculated before and after implementation. Risk ratios were estimated by Poisson regression models. Results A total of 6,834 instances of drug–drug interactions were identified; there was an average of 3.3 DDIs per patient in phase one and 2.5 in phase two, a reduction of 24 % (P = 0.03). There was a 71 % reduction in high-severity drug–drug interaction (P < 0.01). The risk for all DDIs decreased 50 % after the implementation of IM-Pharma (P < 0.01), and for those with high-severity, the reduction was 81 % (P < 0.01). Conclusion The performance of IM-Pharma combined with pharmacist intervention was positive with an expressive reduction in the risk of DDIs.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-07-29T14:35:24Z No. of bitstreams: 1 Nília M. Prado.pdf: 194350 bytes, checksum: 5eb491fa05e94361f44ca4be1915a9b6 (MD5)Made available in DSpace on 2014-07-29T14:35:24Z (GMT). No. of bitstreams: 1 Nília M. Prado.pdf: 194350 bytes, checksum: 5eb491fa05e94361f44ca4be1915a9b6 (MD5) Previous issue date: 2012http://dx.doi.org/ 10.1007/s11096-012-9642-2reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBABrazilDrug–drug interactionsPharmacist interventionPrescriptionsScreening softwareEvaluation of drug–drug interaction screening software combined with pharmacist interventionInternational Journal of Clinical Pharmacyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINALNília M. 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dc.title.pt_BR.fl_str_mv Evaluation of drug–drug interaction screening software combined with pharmacist intervention
dc.title.alternative.pt_BR.fl_str_mv International Journal of Clinical Pharmacy
title Evaluation of drug–drug interaction screening software combined with pharmacist intervention
spellingShingle Evaluation of drug–drug interaction screening software combined with pharmacist intervention
Prado, Nília M.
Brazil
Drug–drug interactions
Pharmacist intervention
Prescriptions
Screening software
title_short Evaluation of drug–drug interaction screening software combined with pharmacist intervention
title_full Evaluation of drug–drug interaction screening software combined with pharmacist intervention
title_fullStr Evaluation of drug–drug interaction screening software combined with pharmacist intervention
title_full_unstemmed Evaluation of drug–drug interaction screening software combined with pharmacist intervention
title_sort Evaluation of drug–drug interaction screening software combined with pharmacist intervention
author Prado, Nília M.
author_facet Prado, Nília M.
Belo, Najara de Oliveira
Moura, Cristiano Soares de
Acurcio, Francisco de Assis
author_role author
author2 Belo, Najara de Oliveira
Moura, Cristiano Soares de
Acurcio, Francisco de Assis
author2_role author
author
author
dc.contributor.author.fl_str_mv Prado, Nília M.
Belo, Najara de Oliveira
Moura, Cristiano Soares de
Acurcio, Francisco de Assis
Prado, Nília M.
Belo, Najara de Oliveira
Moura, Cristiano Soares de
Acurcio, Francisco de Assis
dc.subject.por.fl_str_mv Brazil
Drug–drug interactions
Pharmacist intervention
Prescriptions
Screening software
topic Brazil
Drug–drug interactions
Pharmacist intervention
Prescriptions
Screening software
description Texto completo: acesso restrito. p. 547-552
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2014-07-29T14:35:24Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/15343
dc.identifier.issn.none.fl_str_mv 2210-7703
dc.identifier.number.pt_BR.fl_str_mv v. 34, n. 4
identifier_str_mv 2210-7703
v. 34, n. 4
url http://repositorio.ufba.br/ri/handle/ri/15343
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/ 10.1007/s11096-012-9642-2
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
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reponame_str Repositório Institucional da UFBA
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