Investigation of toxic factors affecting cells of rat brains exposed to 3-methylcatechol
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2007 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/6782 |
Resumo: | p.839-849 |
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1932 |
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Barreto, George Emílio SampaioOliveira, Elineusa Silva deVillar, Flávio Augusto Guerreiro Aragão deSantos, Gleide Souza dosLima, Rute Maria FerreiraCosta, Silvia LimaCosta, Maria de Fátima DiasEgito, Eryvaldo Sócrates TabosaEl-Bachá, Ramon dos SantosBarreto, George Emílio SampaioOliveira, Elineusa Silva deVillar, Flávio Augusto Guerreiro Aragão deSantos, Gleide Souza dosLima, Rute Maria FerreiraCosta, Silvia LimaCosta, Maria de Fátima DiasEgito, Eryvaldo Sócrates TabosaEl-Bachá, Ramon dos Santos2012-09-25T17:47:22Z2012-09-25T17:47:22Z20071516-8913http://www.repositorio.ufba.br/ri/handle/ri/6782v. 50, n. 5p.839-849The aim of this work was to study the effects of 3MC on the peroxidation of biomolecules in nuclear fractions and nonsynaptic mitochondrial respiration in organelles obtained from rat brains. The cytotoxicity towards rat primary astrocytes in vitro was also tested. 3MC at 1mM oxidized consuming oxygen at a rate of 1.98 ± 0.19 µM.min-1 and formed reactive quinones. At the same concentration, 3MC induced peroxidation of biomolecules in nuclear fractions obtained from rat brain homogenates and inhibited state 2 FADH2-linked respiration in nonsynaptic mitochondria. Furthermore, 3MC oxidized in the culture medium, leading to the formation of quinones. This toluene metabolite was cytotoxic to rat primary astrocytes. The concentration that killed 50% of cells after 72 h was 107 mM. The results of the study indicated a direct relationship between cytotoxicity and 3MC oxidation.Submitted by Texeira Ana (atanateixeira@gmail.com) on 2012-09-25T17:47:22Z No. of bitstreams: 1 Barreto, George Emílio Sampaio.pdf: 114060 bytes, checksum: dd744d7abf1fcacb7bcd3775cd9d799d (MD5)Made available in DSpace on 2012-09-25T17:47:22Z (GMT). No. of bitstreams: 1 Barreto, George Emílio Sampaio.pdf: 114060 bytes, checksum: dd744d7abf1fcacb7bcd3775cd9d799d (MD5) Previous issue date: 2007-09CuritibaTecparhttp://dx.doi.org/10.1590/S1516-89132007000500012reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAAstrocytesBrainCytotoxicity3-methylcatecholPeroxidationRespirationInvestigation of toxic factors affecting cells of rat brains exposed to 3-methylcatecholBrazilian Archives of Biology and Technologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessORIGINALBarreto, George Emílio Sampaio.pdfBarreto, George Emílio Sampaio.pdfapplication/pdf114060https://repositorio.ufba.br/bitstream/ri/6782/1/Barreto%2c%20George%20Em%c3%adlio%20Sampaio.pdfdd744d7abf1fcacb7bcd3775cd9d799dMD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/6782/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTBarreto, George Emílio Sampaio.pdf.txtBarreto, George Emílio Sampaio.pdf.txtExtracted texttext/plain36789https://repositorio.ufba.br/bitstream/ri/6782/3/Barreto%2c%20George%20Em%c3%adlio%20Sampaio.pdf.txt09e72565b7a1759f6af0af8493dcdb12MD53ri/67822022-10-03 11:45:30.511oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-10-03T14:45:30Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Investigation of toxic factors affecting cells of rat brains exposed to 3-methylcatechol |
| dc.title.alternative.pt_BR.fl_str_mv |
Brazilian Archives of Biology and Technology |
| title |
Investigation of toxic factors affecting cells of rat brains exposed to 3-methylcatechol |
| spellingShingle |
Investigation of toxic factors affecting cells of rat brains exposed to 3-methylcatechol Barreto, George Emílio Sampaio Astrocytes Brain Cytotoxicity 3-methylcatechol Peroxidation Respiration |
| title_short |
Investigation of toxic factors affecting cells of rat brains exposed to 3-methylcatechol |
| title_full |
Investigation of toxic factors affecting cells of rat brains exposed to 3-methylcatechol |
| title_fullStr |
Investigation of toxic factors affecting cells of rat brains exposed to 3-methylcatechol |
| title_full_unstemmed |
Investigation of toxic factors affecting cells of rat brains exposed to 3-methylcatechol |
| title_sort |
Investigation of toxic factors affecting cells of rat brains exposed to 3-methylcatechol |
| author |
Barreto, George Emílio Sampaio |
| author_facet |
Barreto, George Emílio Sampaio Oliveira, Elineusa Silva de Villar, Flávio Augusto Guerreiro Aragão de Santos, Gleide Souza dos Lima, Rute Maria Ferreira Costa, Silvia Lima Costa, Maria de Fátima Dias Egito, Eryvaldo Sócrates Tabosa El-Bachá, Ramon dos Santos |
| author_role |
author |
| author2 |
Oliveira, Elineusa Silva de Villar, Flávio Augusto Guerreiro Aragão de Santos, Gleide Souza dos Lima, Rute Maria Ferreira Costa, Silvia Lima Costa, Maria de Fátima Dias Egito, Eryvaldo Sócrates Tabosa El-Bachá, Ramon dos Santos |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Barreto, George Emílio Sampaio Oliveira, Elineusa Silva de Villar, Flávio Augusto Guerreiro Aragão de Santos, Gleide Souza dos Lima, Rute Maria Ferreira Costa, Silvia Lima Costa, Maria de Fátima Dias Egito, Eryvaldo Sócrates Tabosa El-Bachá, Ramon dos Santos Barreto, George Emílio Sampaio Oliveira, Elineusa Silva de Villar, Flávio Augusto Guerreiro Aragão de Santos, Gleide Souza dos Lima, Rute Maria Ferreira Costa, Silvia Lima Costa, Maria de Fátima Dias Egito, Eryvaldo Sócrates Tabosa El-Bachá, Ramon dos Santos |
| dc.subject.por.fl_str_mv |
Astrocytes Brain Cytotoxicity 3-methylcatechol Peroxidation Respiration |
| topic |
Astrocytes Brain Cytotoxicity 3-methylcatechol Peroxidation Respiration |
| description |
p.839-849 |
| publishDate |
2007 |
| dc.date.issued.fl_str_mv |
2007 |
| dc.date.accessioned.fl_str_mv |
2012-09-25T17:47:22Z |
| dc.date.available.fl_str_mv |
2012-09-25T17:47:22Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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http://www.repositorio.ufba.br/ri/handle/ri/6782 |
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1516-8913 |
| dc.identifier.number.pt_BR.fl_str_mv |
v. 50, n. 5 |
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1516-8913 v. 50, n. 5 |
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http://www.repositorio.ufba.br/ri/handle/ri/6782 |
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openAccess |
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Tecpar |
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Tecpar |
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http://dx.doi.org/10.1590/S1516-89132007000500012 |
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reponame:Repositório Institucional da UFBA instname:Universidade Federal da Bahia (UFBA) instacron:UFBA |
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