Interactions with apoptotic but not with necrotic neutrophils increase parasite burden in human macrophages infected with Leishmania amazonensis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2008 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/14028 |
Resumo: | Texto completo: acesso restrito. p. 389-396 |
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Afonso, LilianBorges, Valéria de MatosCruz, HeloísaGomes, Flávia L. RibeiroReis, George A. dosDutra, Alberto Augusto NoronhaClarêncio, JorgeOliveira, Camila Indiani deBarral, Aldina Maria PradoBarral-Netto, ManoelBrodskyn, Claudia IdaAfonso, LilianBorges, Valéria de MatosCruz, HeloísaGomes, Flávia L. RibeiroReis, George A. dosDutra, Alberto Augusto NoronhaClarêncio, JorgeOliveira, Camila Indiani deBarral, Aldina Maria PradoBarral-Netto, ManoelBrodskyn, Claudia Ida2013-11-29T19:34:52Z20080741-5400http://repositorio.ufba.br/ri/handle/ri/14028v. 84, n. 2Texto completo: acesso restrito. p. 389-396Neutrophils are involved in the initial steps of most responses to pathogens. In the present study, we evaluated the effects of the interaction of apoptotic vs. necrotic human neutrophils on macrophage infection by Leishmania amazonensis. Phagocytosis of apoptotic, but not viable, neutrophils by Leishmania-infected macrophages led to an increase in parasite burden via a mechanism dependent on TGF-β1 and PGE2. Conversely, infected macrophages’ uptake of necrotic neutrophils induced killing of L. amazonensis. Leishmanicidal activity was dependent on TNF-α and neutrophilic elastase. Nitric oxide was not involved in the killing of parasites, but the interaction of necrotic neutrophils with infected macrophages resulted in high superoxide production, a process reversed by catalase, an inhibitor of reactive oxygen intermediate production. Initial events after Leishmania infection involve interactions with neutrophils; we demonstrate that phagocytosis of these cells in an apoptotic or necrotic stage can influence the outcome of infection, driving either parasite survival or destruction.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-11-29T12:28:34Z No. of bitstreams: 1 10.1189jlb.0108018.pdf: 461168 bytes, checksum: d58a0fa4a1b8c4672a4dc606f788780c (MD5)Approved for entry into archive by Alda Lima da Silva (sivalda@ufba.br) on 2013-11-29T19:34:52Z (GMT) No. of bitstreams: 1 10.1189jlb.0108018.pdf: 461168 bytes, checksum: d58a0fa4a1b8c4672a4dc606f788780c (MD5)Made available in DSpace on 2013-11-29T19:34:52Z (GMT). No. of bitstreams: 1 10.1189jlb.0108018.pdf: 461168 bytes, checksum: d58a0fa4a1b8c4672a4dc606f788780c (MD5) Previous issue date: 2008http://dx.doi.org/10.1189/jlb.0108018reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAApoptosisNecrosisPhagocytosisTGF-β1NELeishmanioseInteractions with apoptotic but not with necrotic neutrophils increase parasite burden in human macrophages infected with Leishmania amazonensisJournal of Leukocyte Biologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengLICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/14028/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52ORIGINAL10.1189jlb.0108018.pdf10.1189jlb.0108018.pdfapplication/pdf461168https://repositorio.ufba.br/bitstream/ri/14028/1/10.1189jlb.0108018.pdfd58a0fa4a1b8c4672a4dc606f788780cMD51TEXT10.1189jlb.0108018.pdf.txt10.1189jlb.0108018.pdf.txtExtracted texttext/plain45298https://repositorio.ufba.br/bitstream/ri/14028/3/10.1189jlb.0108018.pdf.txt9e42456a65617a1dc7547e67ebccf8eeMD53ri/140282022-08-26 11:02:27.27oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-08-26T14:02:27Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Interactions with apoptotic but not with necrotic neutrophils increase parasite burden in human macrophages infected with Leishmania amazonensis |
| dc.title.alternative.pt_BR.fl_str_mv |
Journal of Leukocyte Biology |
| title |
Interactions with apoptotic but not with necrotic neutrophils increase parasite burden in human macrophages infected with Leishmania amazonensis |
| spellingShingle |
Interactions with apoptotic but not with necrotic neutrophils increase parasite burden in human macrophages infected with Leishmania amazonensis Afonso, Lilian Apoptosis Necrosis Phagocytosis TGF-β1 NE Leishmaniose |
| title_short |
Interactions with apoptotic but not with necrotic neutrophils increase parasite burden in human macrophages infected with Leishmania amazonensis |
| title_full |
Interactions with apoptotic but not with necrotic neutrophils increase parasite burden in human macrophages infected with Leishmania amazonensis |
| title_fullStr |
Interactions with apoptotic but not with necrotic neutrophils increase parasite burden in human macrophages infected with Leishmania amazonensis |
| title_full_unstemmed |
Interactions with apoptotic but not with necrotic neutrophils increase parasite burden in human macrophages infected with Leishmania amazonensis |
| title_sort |
Interactions with apoptotic but not with necrotic neutrophils increase parasite burden in human macrophages infected with Leishmania amazonensis |
| author |
Afonso, Lilian |
| author_facet |
Afonso, Lilian Borges, Valéria de Matos Cruz, Heloísa Gomes, Flávia L. Ribeiro Reis, George A. dos Dutra, Alberto Augusto Noronha Clarêncio, Jorge Oliveira, Camila Indiani de Barral, Aldina Maria Prado Barral-Netto, Manoel Brodskyn, Claudia Ida |
| author_role |
author |
| author2 |
Borges, Valéria de Matos Cruz, Heloísa Gomes, Flávia L. Ribeiro Reis, George A. dos Dutra, Alberto Augusto Noronha Clarêncio, Jorge Oliveira, Camila Indiani de Barral, Aldina Maria Prado Barral-Netto, Manoel Brodskyn, Claudia Ida |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Afonso, Lilian Borges, Valéria de Matos Cruz, Heloísa Gomes, Flávia L. Ribeiro Reis, George A. dos Dutra, Alberto Augusto Noronha Clarêncio, Jorge Oliveira, Camila Indiani de Barral, Aldina Maria Prado Barral-Netto, Manoel Brodskyn, Claudia Ida Afonso, Lilian Borges, Valéria de Matos Cruz, Heloísa Gomes, Flávia L. Ribeiro Reis, George A. dos Dutra, Alberto Augusto Noronha Clarêncio, Jorge Oliveira, Camila Indiani de Barral, Aldina Maria Prado Barral-Netto, Manoel Brodskyn, Claudia Ida |
| dc.subject.por.fl_str_mv |
Apoptosis Necrosis Phagocytosis TGF-β1 NE Leishmaniose |
| topic |
Apoptosis Necrosis Phagocytosis TGF-β1 NE Leishmaniose |
| description |
Texto completo: acesso restrito. p. 389-396 |
| publishDate |
2008 |
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2008 |
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2013-11-29T19:34:52Z |
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info:eu-repo/semantics/publishedVersion |
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http://repositorio.ufba.br/ri/handle/ri/14028 |
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0741-5400 |
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v. 84, n. 2 |
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0741-5400 v. 84, n. 2 |
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http://repositorio.ufba.br/ri/handle/ri/14028 |
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