Changes in gut microbiota due to supplemented fatty acids in diet-induced obese mice

Detalhes bibliográficos
Autor(a) principal: Mujico, Jorge R.
Data de Publicação: 2013
Outros Autores: Baccan, Gyselle Chrystina, Gheorghe, Alina, Díaz, Ligia E., Marcos, Ascensión
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/15044
Resumo: Texto completo: acesso restrito. p. 711-720
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spelling Mujico, Jorge R.Baccan, Gyselle ChrystinaGheorghe, AlinaDíaz, Ligia E.Marcos, AscensiónMujico, Jorge R.Baccan, Gyselle ChrystinaGheorghe, AlinaDíaz, Ligia E.Marcos, Ascensión2014-06-04T16:11:13Z20130007-1145http://repositorio.ufba.br/ri/handle/ri/15044v. 110, n. 4Texto completo: acesso restrito. p. 711-720Consumption of a high-fat diet (HFD), which is associated with chronic ‘low-grade’ systemic inflammation, alters the gut microbiota (GM). The aim of the present study was to investigate the ability of an oleic acid-derived compound (S1) and a combination of n-3 fatty acids (EPA and DHA, S2) to modulate both body weight and the GM in HFD-induced obese mice. A total of eighty mice were fed either a control diet or a HFD, non-supplemented or supplemented with S1 or S2. At week 19, faeces were collected in order to analyse the GM. Group-specific primers for accurate quantification of several major bacterial groups from faecal samples were assayed using quantitative PCR. The HFD induced an increase in body weight, which was reduced by supplementation with S1. Furthermore, S1 supplementation markedly increased total bacterial density and restored the proportions of bacteria that were increased (i.e. clostridial cluster XIVa and Enterobacteriales) or decreased (i.e. Bifidobacterium spp.) during HFD feeding. S2 supplementation significantly increased the quantities of Firmicutes (especially the Lactobacillus group). Correlation analysis revealed that body weight correlated positively with the phylum Firmicutes and clostridial cluster XIVa, and negatively with the phylum Bacteroidetes. In conclusion, the consumption of a HFD induced changes in the faecal microbiota, which were associated with the appearance of an obese phenotype. Supplementation of the HFD with S1 counteracted HFD-induced gut dysbiosis, together with an improvement in body weight. These data support a role for certain fatty acids as interesting nutrients related to obesity prevention.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-05-12T14:31:15Z No. of bitstreams: 1 0007114512005612a.pdf: 247205 bytes, checksum: 5a9aa17581d2d0f6cd6df19fddfb0f14 (MD5)Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2014-06-04T16:11:12Z (GMT) No. of bitstreams: 1 0007114512005612a.pdf: 247205 bytes, checksum: 5a9aa17581d2d0f6cd6df19fddfb0f14 (MD5)Made available in DSpace on 2014-06-04T16:11:13Z (GMT). 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dc.title.pt_BR.fl_str_mv Changes in gut microbiota due to supplemented fatty acids in diet-induced obese mice
dc.title.alternative.pt_BR.fl_str_mv British Journal of Nutrition
title Changes in gut microbiota due to supplemented fatty acids in diet-induced obese mice
spellingShingle Changes in gut microbiota due to supplemented fatty acids in diet-induced obese mice
Mujico, Jorge R.
Gut microbiota
Fatty acids
Obese mice
Quantitative PCR
Polymerase Chain Reaction
Fatty acids
Mice, Obese
title_short Changes in gut microbiota due to supplemented fatty acids in diet-induced obese mice
title_full Changes in gut microbiota due to supplemented fatty acids in diet-induced obese mice
title_fullStr Changes in gut microbiota due to supplemented fatty acids in diet-induced obese mice
title_full_unstemmed Changes in gut microbiota due to supplemented fatty acids in diet-induced obese mice
title_sort Changes in gut microbiota due to supplemented fatty acids in diet-induced obese mice
author Mujico, Jorge R.
author_facet Mujico, Jorge R.
Baccan, Gyselle Chrystina
Gheorghe, Alina
Díaz, Ligia E.
Marcos, Ascensión
author_role author
author2 Baccan, Gyselle Chrystina
Gheorghe, Alina
Díaz, Ligia E.
Marcos, Ascensión
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Mujico, Jorge R.
Baccan, Gyselle Chrystina
Gheorghe, Alina
Díaz, Ligia E.
Marcos, Ascensión
Mujico, Jorge R.
Baccan, Gyselle Chrystina
Gheorghe, Alina
Díaz, Ligia E.
Marcos, Ascensión
dc.subject.por.fl_str_mv Gut microbiota
Fatty acids
Obese mice
Quantitative PCR
Polymerase Chain Reaction
Fatty acids
Mice, Obese
topic Gut microbiota
Fatty acids
Obese mice
Quantitative PCR
Polymerase Chain Reaction
Fatty acids
Mice, Obese
description Texto completo: acesso restrito. p. 711-720
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2014-06-04T16:11:13Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/15044
dc.identifier.issn.none.fl_str_mv 0007-1145
dc.identifier.number.pt_BR.fl_str_mv v. 110, n. 4
identifier_str_mv 0007-1145
v. 110, n. 4
url http://repositorio.ufba.br/ri/handle/ri/15044
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1017/S0007114512005612
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
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reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
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