Functional Polymorphisms in IL13 Are Protective against High Schistosoma mansoni Infection Intensity in a Brazilian Population

Detalhes bibliográficos
Autor(a) principal: Grant, Audrey V.
Data de Publicação: 2012
Outros Autores: Araujo, Maria Ilma Andrade Santos, Ponte, Eduardo Vieira, Oliveira, Ricardo Riccio, Gao, Peisong, Cruz Filho, Álvaro Augusto Souza da, Barnes, Kathleen C., Beaty, Terri H.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/16414
Resumo: Texto completo: acesso restrito. p. 1-6
id UFBA-2_725d117a8b691617f465ad8ae7a62aca
oai_identifier_str oai:repositorio.ufba.br:ri/16414
network_acronym_str UFBA-2
network_name_str Repositório Institucional da UFBA
repository_id_str 1932
spelling Grant, Audrey V.Araujo, Maria Ilma Andrade SantosPonte, Eduardo VieiraOliveira, Ricardo RiccioGao, PeisongCruz Filho, Álvaro Augusto Souza daBarnes, Kathleen C.Beaty, Terri H.Grant, Audrey V.Araujo, Maria Ilma Andrade SantosPonte, Eduardo VieiraOliveira, Ricardo RiccioGao, PeisongCruz Filho, Álvaro Augusto Souza daBarnes, Kathleen C.Beaty, Terri H.2014-10-14T12:32:29Z20121932-6203http://repositorio.ufba.br/ri/handle/ri/16414v. 7, n. 5Texto completo: acesso restrito. p. 1-6Background IL-13 is a signature cytokine of the helper T cell type 2 (TH2) pathway which underlies host defense to helminthic infection and activates production of IgE in both parasitized populations and in urban settings after allergen exposure. Methodology/Principal Findings Two functional polymorphisms in IL13, rs1800925 (or c.1-1111C>T) and rs20541 (or R130Q) were previously found to be associated with Schistosoma hematobium infection intensity. They have not been thoroughly explored in S. mansoni-endemic populations, however, and were selected along with 5 tagging SNPs for genotyping in 812 individuals in 318 nuclear families from a schistosomiasis-endemic area of Conde, Bahia, in Brazil. Regression models using GEE to account for family membership and family-based quantitative transmission disequilibrium tests (QTDT) were used to evaluate associations with total serum IgE (tIgE) levels and S. mansoni fecal egg counts adjusted for non-genetic covariates. We identified a protective effect for the T allele at rs20541 (P = 0.005) against high S. mansoni egg counts, corroborated by QTDT (P = 0.014). Our findings also suggested evidence for protective effects for the T allele at rs1800925 and A allele at rs2066960 after GEE analysis only (P = 0.050, 0.0002). Conclusions/Significance. The two functional variants in IL13 are protective against high S. mansoni egg counts. These markers showed no evidence of association with tIgE levels, unlike tIgE levels previously studied in non-parasitized or atopic study populations.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-08-11T12:34:39Z No. of bitstreams: 1 Eduardo Vieira Ponte.pdf: 636555 bytes, checksum: 4b73961c2ce88455088f752041fd2945 (MD5)Rejected by Delba Rosa (delba@ufba.br), reason: Por gentileza, Coloque os autores na ordem sequencial do artigo. Grata on 2014-10-09T15:53:33Z (GMT)Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-10-14T11:28:16Z No. of bitstreams: 1 Eduardo Vieira Ponte.pdf: 636555 bytes, checksum: 4b73961c2ce88455088f752041fd2945 (MD5)Approved for entry into archive by Delba Rosa (delba@ufba.br) on 2014-10-14T12:32:28Z (GMT) No. of bitstreams: 1 Eduardo Vieira Ponte.pdf: 636555 bytes, checksum: 4b73961c2ce88455088f752041fd2945 (MD5)Made available in DSpace on 2014-10-14T12:32:29Z (GMT). No. of bitstreams: 1 Eduardo Vieira Ponte.pdf: 636555 bytes, checksum: 4b73961c2ce88455088f752041fd2945 (MD5) Previous issue date: 2012http://dx.doi.org/ 10.1371/journal.pone.0035863reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAFunctional Polymorphisms in IL13 Are Protective against High Schistosoma mansoni Infection Intensity in a Brazilian PopulationPLoS ONEinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengLICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/16414/2/license.txt0d4b811ef71182510d2015daa7c8a900MD52ORIGINALEduardo Vieira Ponte.pdfEduardo Vieira Ponte.pdfapplication/pdf636555https://repositorio.ufba.br/bitstream/ri/16414/1/Eduardo%20Vieira%20Ponte.pdf4b73961c2ce88455088f752041fd2945MD51TEXTEduardo Vieira Ponte.pdf.txtEduardo Vieira Ponte.pdf.txtExtracted texttext/plain36586https://repositorio.ufba.br/bitstream/ri/16414/3/Eduardo%20Vieira%20Ponte.pdf.txtcce30e272688c41b19ac6e5634f66ef7MD53ri/164142022-08-08 13:18:13.107oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-08-08T16:18:13Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Functional Polymorphisms in IL13 Are Protective against High Schistosoma mansoni Infection Intensity in a Brazilian Population
dc.title.alternative.pt_BR.fl_str_mv PLoS ONE
title Functional Polymorphisms in IL13 Are Protective against High Schistosoma mansoni Infection Intensity in a Brazilian Population
spellingShingle Functional Polymorphisms in IL13 Are Protective against High Schistosoma mansoni Infection Intensity in a Brazilian Population
Grant, Audrey V.
title_short Functional Polymorphisms in IL13 Are Protective against High Schistosoma mansoni Infection Intensity in a Brazilian Population
title_full Functional Polymorphisms in IL13 Are Protective against High Schistosoma mansoni Infection Intensity in a Brazilian Population
title_fullStr Functional Polymorphisms in IL13 Are Protective against High Schistosoma mansoni Infection Intensity in a Brazilian Population
title_full_unstemmed Functional Polymorphisms in IL13 Are Protective against High Schistosoma mansoni Infection Intensity in a Brazilian Population
title_sort Functional Polymorphisms in IL13 Are Protective against High Schistosoma mansoni Infection Intensity in a Brazilian Population
author Grant, Audrey V.
author_facet Grant, Audrey V.
Araujo, Maria Ilma Andrade Santos
Ponte, Eduardo Vieira
Oliveira, Ricardo Riccio
Gao, Peisong
Cruz Filho, Álvaro Augusto Souza da
Barnes, Kathleen C.
Beaty, Terri H.
author_role author
author2 Araujo, Maria Ilma Andrade Santos
Ponte, Eduardo Vieira
Oliveira, Ricardo Riccio
Gao, Peisong
Cruz Filho, Álvaro Augusto Souza da
Barnes, Kathleen C.
Beaty, Terri H.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Grant, Audrey V.
Araujo, Maria Ilma Andrade Santos
Ponte, Eduardo Vieira
Oliveira, Ricardo Riccio
Gao, Peisong
Cruz Filho, Álvaro Augusto Souza da
Barnes, Kathleen C.
Beaty, Terri H.
Grant, Audrey V.
Araujo, Maria Ilma Andrade Santos
Ponte, Eduardo Vieira
Oliveira, Ricardo Riccio
Gao, Peisong
Cruz Filho, Álvaro Augusto Souza da
Barnes, Kathleen C.
Beaty, Terri H.
description Texto completo: acesso restrito. p. 1-6
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2014-10-14T12:32:29Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/16414
dc.identifier.issn.none.fl_str_mv 1932-6203
dc.identifier.number.pt_BR.fl_str_mv v. 7, n. 5
identifier_str_mv 1932-6203
v. 7, n. 5
url http://repositorio.ufba.br/ri/handle/ri/16414
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/ 10.1371/journal.pone.0035863
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
bitstream.url.fl_str_mv https://repositorio.ufba.br/bitstream/ri/16414/2/license.txt
https://repositorio.ufba.br/bitstream/ri/16414/1/Eduardo%20Vieira%20Ponte.pdf
https://repositorio.ufba.br/bitstream/ri/16414/3/Eduardo%20Vieira%20Ponte.pdf.txt
bitstream.checksum.fl_str_mv 0d4b811ef71182510d2015daa7c8a900
4b73961c2ce88455088f752041fd2945
cce30e272688c41b19ac6e5634f66ef7
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)
repository.mail.fl_str_mv
_version_ 1808459483566833664

Registros relacionados