Administration of granulocyte colony-stimulating factor induces immunomodulation, recruitment of T regulatory cells, reduction of myocarditis and decrease of parasite load in a mouse model of chronic Chagas disease cardiomyopathy
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2013 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/14847 |
Resumo: | Texto completo: acesso restrito. p. 4691-4702 |
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Vasconcelos, Juliana FragaSouza, Bruno Solano de FreitasLins, Thayse F. S.Garcia, Letícia M. S.Kaneto, Carla MartinsSampaio, Geraldo P.Alcântara, Adriano Costa deAlcântara, Adriano Costa deMeira, Cássio S.Macambira, Simone GarciaSantos, Ricardo Ribeiro dosSoares, Milena Botelho PereiraVasconcelos, Juliana FragaSouza, Bruno Solano de FreitasLins, Thayse F. S.Garcia, Letícia M. S.Kaneto, Carla MartinsSampaio, Geraldo P.Alcântara, Adriano Costa deAlcântara, Adriano Costa deMeira, Cássio S.Macambira, Simone GarciaSantos, Ricardo Ribeiro dosSoares, Milena Botelho Pereira2014-04-22T18:45:56Z20130892-6638http://repositorio.ufba.br/ri/handle/ri/14847v. 27, n. 12Texto completo: acesso restrito. p. 4691-4702Chagas disease, caused by Trypanosoma cruzi infection, is a leading cause of heart failure in Latin American countries. In a previous study, we showed beneficial effects of granulocyte colony-stimulating factor (G-CSF) administration in the heart function of mice with chronic T. cruzi infection. Presently, we investigated the mechanisms by which this cytokine exerts its beneficial effects. Mice chronically infected with T. cruzi were treated with human recombinant G-CSF (3 courses of 200 μg/kg/d for 5 d). Inflammation and fibrosis were reduced in the hearts of G-CSF-treated mice, compared with the hearts of vehicle-treated mice, which correlated with decreased syndecan-4, intercellular adhesion molecule-1, and galectin-3 expressions. Marked reductions in interferon-γ and tumor necrosis factor-α and increased interleukin-10 and transforming growth factor-β were found after G-CSF administration. Because the therapy did not induce a Th1 to Th2 immune response deviation, we investigated the role of regulatory T (Treg) cells. A significant increase in CD3+Foxp3+ cells was observed in the hearts of G-CSF-treated mice. In addition, a reduction of parasitism was observed after G-CSF treatment. Our results indicate a role of Treg cells in the immunosuppression induced by G-CSF treatment and reinforces its potential therapeutic use for patients with Chagas disease.—Vasconcelos, J. F., Souza, B. S. F., Lins, T. F. S., Garcia, L. M. S., Kaneto, C. M., Smapaio, G. P., de Alcântara, A. C., Meira, C. S., Macambira, S. G., Ribeiro-dos-Santos, R., Soares, M. B. P. Administration of granulocyte colony-stimulating factor induces immunomodulation, recruitment of T regulatory cells, reduction of myocarditis and decrease of parasite load in a mouse model of chronic Chagas disease cardiomyopathy.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-03-27T13:07:52Z No. of bitstreams: 1 10.1096fj.13-229351.pdf: 1028504 bytes, checksum: cf15c623e7c8b011509bf0ed3eb8c71b (MD5)Approved for entry into archive by Alda Lima da Silva (sivalda@ufba.br) on 2014-04-22T18:45:56Z (GMT) No. of bitstreams: 1 10.1096fj.13-229351.pdf: 1028504 bytes, checksum: cf15c623e7c8b011509bf0ed3eb8c71b (MD5)Made available in DSpace on 2014-04-22T18:45:56Z (GMT). No. of bitstreams: 1 10.1096fj.13-229351.pdf: 1028504 bytes, checksum: cf15c623e7c8b011509bf0ed3eb8c71b (MD5) Previous issue date: 2013http://dx.doi.org/10.1096/fj.13-229351reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBATrypanosoma cruziCytokine therapyInflammationFibrosisTh1 modulationAdministration of granulocyte colony-stimulating factor induces immunomodulation, recruitment of T regulatory cells, reduction of myocarditis and decrease of parasite load in a mouse model of chronic Chagas disease cardiomyopathyFASEB Journalinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINAL10.1096fj.13-229351.pdf10.1096fj.13-229351.pdfapplication/pdf1028504https://repositorio.ufba.br/bitstream/ri/14847/1/10.1096fj.13-229351.pdfcf15c623e7c8b011509bf0ed3eb8c71bMD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/14847/2/license.txt0d4b811ef71182510d2015daa7c8a900MD52TEXT10.1096fj.13-229351.pdf.txt10.1096fj.13-229351.pdf.txtExtracted texttext/plain57847https://repositorio.ufba.br/bitstream/ri/14847/3/10.1096fj.13-229351.pdf.txt00fccc403e66d743571e13f0914caf75MD53ri/148472022-07-05 14:04:03.027oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:04:03Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Administration of granulocyte colony-stimulating factor induces immunomodulation, recruitment of T regulatory cells, reduction of myocarditis and decrease of parasite load in a mouse model of chronic Chagas disease cardiomyopathy |
| dc.title.alternative.pt_BR.fl_str_mv |
FASEB Journal |
| title |
Administration of granulocyte colony-stimulating factor induces immunomodulation, recruitment of T regulatory cells, reduction of myocarditis and decrease of parasite load in a mouse model of chronic Chagas disease cardiomyopathy |
| spellingShingle |
Administration of granulocyte colony-stimulating factor induces immunomodulation, recruitment of T regulatory cells, reduction of myocarditis and decrease of parasite load in a mouse model of chronic Chagas disease cardiomyopathy Vasconcelos, Juliana Fraga Trypanosoma cruzi Cytokine therapy Inflammation Fibrosis Th1 modulation |
| title_short |
Administration of granulocyte colony-stimulating factor induces immunomodulation, recruitment of T regulatory cells, reduction of myocarditis and decrease of parasite load in a mouse model of chronic Chagas disease cardiomyopathy |
| title_full |
Administration of granulocyte colony-stimulating factor induces immunomodulation, recruitment of T regulatory cells, reduction of myocarditis and decrease of parasite load in a mouse model of chronic Chagas disease cardiomyopathy |
| title_fullStr |
Administration of granulocyte colony-stimulating factor induces immunomodulation, recruitment of T regulatory cells, reduction of myocarditis and decrease of parasite load in a mouse model of chronic Chagas disease cardiomyopathy |
| title_full_unstemmed |
Administration of granulocyte colony-stimulating factor induces immunomodulation, recruitment of T regulatory cells, reduction of myocarditis and decrease of parasite load in a mouse model of chronic Chagas disease cardiomyopathy |
| title_sort |
Administration of granulocyte colony-stimulating factor induces immunomodulation, recruitment of T regulatory cells, reduction of myocarditis and decrease of parasite load in a mouse model of chronic Chagas disease cardiomyopathy |
| author |
Vasconcelos, Juliana Fraga |
| author_facet |
Vasconcelos, Juliana Fraga Souza, Bruno Solano de Freitas Lins, Thayse F. S. Garcia, Letícia M. S. Kaneto, Carla Martins Sampaio, Geraldo P. Alcântara, Adriano Costa de Meira, Cássio S. Macambira, Simone Garcia Santos, Ricardo Ribeiro dos Soares, Milena Botelho Pereira |
| author_role |
author |
| author2 |
Souza, Bruno Solano de Freitas Lins, Thayse F. S. Garcia, Letícia M. S. Kaneto, Carla Martins Sampaio, Geraldo P. Alcântara, Adriano Costa de Meira, Cássio S. Macambira, Simone Garcia Santos, Ricardo Ribeiro dos Soares, Milena Botelho Pereira |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Vasconcelos, Juliana Fraga Souza, Bruno Solano de Freitas Lins, Thayse F. S. Garcia, Letícia M. S. Kaneto, Carla Martins Sampaio, Geraldo P. Alcântara, Adriano Costa de Alcântara, Adriano Costa de Meira, Cássio S. Macambira, Simone Garcia Santos, Ricardo Ribeiro dos Soares, Milena Botelho Pereira Vasconcelos, Juliana Fraga Souza, Bruno Solano de Freitas Lins, Thayse F. S. Garcia, Letícia M. S. Kaneto, Carla Martins Sampaio, Geraldo P. Alcântara, Adriano Costa de Alcântara, Adriano Costa de Meira, Cássio S. Macambira, Simone Garcia Santos, Ricardo Ribeiro dos Soares, Milena Botelho Pereira |
| dc.subject.por.fl_str_mv |
Trypanosoma cruzi Cytokine therapy Inflammation Fibrosis Th1 modulation |
| topic |
Trypanosoma cruzi Cytokine therapy Inflammation Fibrosis Th1 modulation |
| description |
Texto completo: acesso restrito. p. 4691-4702 |
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2013 |
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2013 |
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2014-04-22T18:45:56Z |
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0892-6638 |
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v. 27, n. 12 |
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0892-6638 v. 27, n. 12 |
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