Evidence for Reductive Genome Evolution and Lateral Acquisition of Virulence Functions in Two Corynebacterium pseudotuberculosis Strains
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2011 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/5467 |
Resumo: | p. 1-15 |
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Ruiz, Jerônimo ConceiçãoFerreira, Vívian D'Afonseca da SilvaSilva, Artur Luiz da Costa daAli, AmjadPinto, Anne CybelleSantos, Anderson Rodrigues dosRocha, Aryane Aparecida Magalhães CassianoLopes, Débora de OliveiraDorella, Fernanda AlvesPacheco, Luis Gustavo CarvalhoCosta, Marcilia Pinheiro daTurk, Meritxell ZuritaSeyffert, NúbiaMoraes, Pablo Matias Ribeiro de OliveiraSoares, Siomar de CastroAlmeida, Sintia Silva deCastro, Thiago Luiz de PaulaAbreu, Vinicius Augusto Carvalho deTrost, EvaBaumbach, JanTauch, AndreasSchneider, Maria Paula CruzMcCulloch, John AnthonyCerdeira, Louise TeixeiraRamos, Rommel Thiago JucaZerlotini, AdhemarDominitini, AndersonResende, Daniela de MeloCoser, Elisângela MonteiroOliveira, Luciana Márcia dePedrosa, André LuizUeira-Vieira, CarlosGuimarães, Claudia TeixeiraBartholomeu, Daniela C.Oliveira, Magalhães deSantos, Fabrício R.Rabelo, Élida MaraLobo, Francisco PereiraFranco, Gloria ReginaCosta, Ana FláviaCastro, Ieso M.Dias, Sílvia Regina CostaFerro, Jesus AparecidoOrtega, José MiguelPaiva, Luciano VilelaGoulart Filho, Luiz RicardoAlmeida, Juliana FrancoFerro, Maria Inês TiraboschiCarneiro, Newton PortilhoFalcão, Paula Regina KuserGrynberg, PriscilaTeixeira, Santuza Maria RibeiroBrommonschenkel, SérgioOliveira, Sérgio CostaNascimento, Roberto José MeyerMoore, Robert J.Miyoshi, AndersonOliveira, Guilherme C.Azevedo, Vasco Ariston de CarvalhoRuiz, Jerônimo ConceiçãoFerreira, Vívian D'Afonseca da SilvaSilva, Artur Luiz da Costa daAli, AmjadPinto, Anne CybelleSantos, Anderson Rodrigues dosRocha, Aryane Aparecida Magalhães CassianoLopes, Débora de OliveiraDorella, Fernanda AlvesPacheco, Luis Gustavo CarvalhoCosta, Marcilia Pinheiro daTurk, Meritxell ZuritaSeyffert, NúbiaMoraes, Pablo Matias Ribeiro de OliveiraSoares, Siomar de CastroAlmeida, Sintia Silva deCastro, Thiago Luiz de PaulaAbreu, Vinicius Augusto Carvalho deTrost, EvaBaumbach, JanTauch, AndreasSchneider, Maria Paula CruzMcCulloch, John AnthonyCerdeira, Louise TeixeiraRamos, Rommel Thiago JucaZerlotini, AdhemarDominitini, AndersonResende, Daniela de MeloCoser, Elisângela MonteiroOliveira, Luciana Márcia dePedrosa, André LuizUeira-Vieira, CarlosGuimarães, Claudia TeixeiraBartholomeu, Daniela C.Oliveira, Magalhães deSantos, Fabrício R.Rabelo, Élida MaraLobo, Francisco PereiraFranco, Gloria ReginaCosta, Ana FláviaCastro, Ieso M.Dias, Sílvia Regina CostaFerro, Jesus AparecidoOrtega, José MiguelPaiva, Luciano VilelaGoulart Filho, Luiz RicardoAlmeida, Juliana FrancoFerro, Maria Inês TiraboschiCarneiro, Newton PortilhoFalcão, Paula Regina KuserGrynberg, PriscilaTeixeira, Santuza Maria RibeiroBrommonschenkel, SérgioOliveira, Sérgio CostaNascimento, Roberto José MeyerMoore, Robert J.Miyoshi, AndersonOliveira, Guilherme C.Azevedo, Vasco Ariston de Carvalho2012-02-27T13:03:23Z2012-02-27T13:03:23Z20111932-6203http://www.repositorio.ufba.br/ri/handle/ri/5467v. 6, n. 4.p. 1-15Background: Corynebacterium pseudotuberculosis, a Gram-positive, facultative intracellular pathogen, is the etiologic agent of the disease known as caseous lymphadenitis (CL). CL mainly affects small ruminants, such as goats and sheep; it also causes infections in humans, though rarely. This species is distributed worldwide, but it has the most serious economic impact in Oceania, Africa and South America. Although C. pseudotuberculosis causes major health and productivity problems for livestock, little is known about the molecular basis of its pathogenicity. Methodology and Findings: We characterized two C. pseudotuberculosis genomes (Cp1002, isolated from goats; and CpC231, isolated from sheep). Analysis of the predicted genomes showed high similarity in genomic architecture, gene content and genetic order. When C. pseudotuberculosis was compared with other Corynebacterium species, it became evident that this pathogenic species has lost numerous genes, resulting in one of the smallest genomes in the genus. Other differences that could be part of the adaptation to pathogenicity include a lower GC content, of about 52%, and a reduced gene repertoire. The C. pseudotuberculosis genome also includes seven putative pathogenicity islands, which contain several classical virulence factors, including genes for fimbrial subunits, adhesion factors, iron uptake and secreted toxins. Additionally, all of the virulence factors in the islands have characteristics that indicate horizontal transfer. Conclusions: These particular genome characteristics of C. pseudotuberculosis, as well as its acquired virulence factors in pathogenicity islands, provide evidence of its lifestyle and of the pathogenicity pathways used by this pathogen in the infection process. All genomes cited in this study are available in the NCBI Genbank database (http://www.ncbi.nlm.nih.gov/ genbank/) under accession numbers CP001809 and CP001829.Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2012-02-27T13:03:23Z No. of bitstreams: 1 journal.pone.0018551.pdf: 410957 bytes, checksum: 9150a5f0fbe637d4f1197a80e401c8d2 (MD5)Made available in DSpace on 2012-02-27T13:03:23Z (GMT). No. of bitstreams: 1 journal.pone.0018551.pdf: 410957 bytes, checksum: 9150a5f0fbe637d4f1197a80e401c8d2 (MD5) Previous issue date: 2011DOI: 10.1371/journal.pone.0018551reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAEvidence for Reductive Genome Evolution and Lateral Acquisition of Virulence Functions in Two Corynebacterium pseudotuberculosis StrainsPLoS ONEinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessORIGINALjournal.pone.0018551.pdfjournal.pone.0018551.pdfapplication/pdf410957https://repositorio.ufba.br/bitstream/ri/5467/1/journal.pone.0018551.pdf9150a5f0fbe637d4f1197a80e401c8d2MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/5467/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTjournal.pone.0018551.pdf.txtjournal.pone.0018551.pdf.txtExtracted texttext/plain87625https://repositorio.ufba.br/bitstream/ri/5467/3/journal.pone.0018551.pdf.txtd64e3af8b7071956f77d6f7e11283f19MD53ri/54672022-07-05 14:03:21.464oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:21Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Evidence for Reductive Genome Evolution and Lateral Acquisition of Virulence Functions in Two Corynebacterium pseudotuberculosis Strains |
| dc.title.alternative.pt_BR.fl_str_mv |
PLoS ONE |
| title |
Evidence for Reductive Genome Evolution and Lateral Acquisition of Virulence Functions in Two Corynebacterium pseudotuberculosis Strains |
| spellingShingle |
Evidence for Reductive Genome Evolution and Lateral Acquisition of Virulence Functions in Two Corynebacterium pseudotuberculosis Strains Ruiz, Jerônimo Conceição |
| title_short |
Evidence for Reductive Genome Evolution and Lateral Acquisition of Virulence Functions in Two Corynebacterium pseudotuberculosis Strains |
| title_full |
Evidence for Reductive Genome Evolution and Lateral Acquisition of Virulence Functions in Two Corynebacterium pseudotuberculosis Strains |
| title_fullStr |
Evidence for Reductive Genome Evolution and Lateral Acquisition of Virulence Functions in Two Corynebacterium pseudotuberculosis Strains |
| title_full_unstemmed |
Evidence for Reductive Genome Evolution and Lateral Acquisition of Virulence Functions in Two Corynebacterium pseudotuberculosis Strains |
| title_sort |
Evidence for Reductive Genome Evolution and Lateral Acquisition of Virulence Functions in Two Corynebacterium pseudotuberculosis Strains |
| author |
Ruiz, Jerônimo Conceição |
| author_facet |
Ruiz, Jerônimo Conceição Ferreira, Vívian D'Afonseca da Silva Silva, Artur Luiz da Costa da Ali, Amjad Pinto, Anne Cybelle Santos, Anderson Rodrigues dos Rocha, Aryane Aparecida Magalhães Cassiano Lopes, Débora de Oliveira Dorella, Fernanda Alves Pacheco, Luis Gustavo Carvalho Costa, Marcilia Pinheiro da Turk, Meritxell Zurita Seyffert, Núbia Moraes, Pablo Matias Ribeiro de Oliveira Soares, Siomar de Castro Almeida, Sintia Silva de Castro, Thiago Luiz de Paula Abreu, Vinicius Augusto Carvalho de Trost, Eva Baumbach, Jan Tauch, Andreas Schneider, Maria Paula Cruz McCulloch, John Anthony Cerdeira, Louise Teixeira Ramos, Rommel Thiago Juca Zerlotini, Adhemar Dominitini, Anderson Resende, Daniela de Melo Coser, Elisângela Monteiro Oliveira, Luciana Márcia de Pedrosa, André Luiz Ueira-Vieira, Carlos Guimarães, Claudia Teixeira Bartholomeu, Daniela C. Oliveira, Magalhães de Santos, Fabrício R. Rabelo, Élida Mara Lobo, Francisco Pereira Franco, Gloria Regina Costa, Ana Flávia Castro, Ieso M. Dias, Sílvia Regina Costa Ferro, Jesus Aparecido Ortega, José Miguel Paiva, Luciano Vilela Goulart Filho, Luiz Ricardo Almeida, Juliana Franco Ferro, Maria Inês Tiraboschi Carneiro, Newton Portilho Falcão, Paula Regina Kuser Grynberg, Priscila Teixeira, Santuza Maria Ribeiro Brommonschenkel, Sérgio Oliveira, Sérgio Costa Nascimento, Roberto José Meyer Moore, Robert J. Miyoshi, Anderson Oliveira, Guilherme C. Azevedo, Vasco Ariston de Carvalho |
| author_role |
author |
| author2 |
Ferreira, Vívian D'Afonseca da Silva Silva, Artur Luiz da Costa da Ali, Amjad Pinto, Anne Cybelle Santos, Anderson Rodrigues dos Rocha, Aryane Aparecida Magalhães Cassiano Lopes, Débora de Oliveira Dorella, Fernanda Alves Pacheco, Luis Gustavo Carvalho Costa, Marcilia Pinheiro da Turk, Meritxell Zurita Seyffert, Núbia Moraes, Pablo Matias Ribeiro de Oliveira Soares, Siomar de Castro Almeida, Sintia Silva de Castro, Thiago Luiz de Paula Abreu, Vinicius Augusto Carvalho de Trost, Eva Baumbach, Jan Tauch, Andreas Schneider, Maria Paula Cruz McCulloch, John Anthony Cerdeira, Louise Teixeira Ramos, Rommel Thiago Juca Zerlotini, Adhemar Dominitini, Anderson Resende, Daniela de Melo Coser, Elisângela Monteiro Oliveira, Luciana Márcia de Pedrosa, André Luiz Ueira-Vieira, Carlos Guimarães, Claudia Teixeira Bartholomeu, Daniela C. Oliveira, Magalhães de Santos, Fabrício R. Rabelo, Élida Mara Lobo, Francisco Pereira Franco, Gloria Regina Costa, Ana Flávia Castro, Ieso M. Dias, Sílvia Regina Costa Ferro, Jesus Aparecido Ortega, José Miguel Paiva, Luciano Vilela Goulart Filho, Luiz Ricardo Almeida, Juliana Franco Ferro, Maria Inês Tiraboschi Carneiro, Newton Portilho Falcão, Paula Regina Kuser Grynberg, Priscila Teixeira, Santuza Maria Ribeiro Brommonschenkel, Sérgio Oliveira, Sérgio Costa Nascimento, Roberto José Meyer Moore, Robert J. Miyoshi, Anderson Oliveira, Guilherme C. Azevedo, Vasco Ariston de Carvalho |
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author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
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Ruiz, Jerônimo Conceição Ferreira, Vívian D'Afonseca da Silva Silva, Artur Luiz da Costa da Ali, Amjad Pinto, Anne Cybelle Santos, Anderson Rodrigues dos Rocha, Aryane Aparecida Magalhães Cassiano Lopes, Débora de Oliveira Dorella, Fernanda Alves Pacheco, Luis Gustavo Carvalho Costa, Marcilia Pinheiro da Turk, Meritxell Zurita Seyffert, Núbia Moraes, Pablo Matias Ribeiro de Oliveira Soares, Siomar de Castro Almeida, Sintia Silva de Castro, Thiago Luiz de Paula Abreu, Vinicius Augusto Carvalho de Trost, Eva Baumbach, Jan Tauch, Andreas Schneider, Maria Paula Cruz McCulloch, John Anthony Cerdeira, Louise Teixeira Ramos, Rommel Thiago Juca Zerlotini, Adhemar Dominitini, Anderson Resende, Daniela de Melo Coser, Elisângela Monteiro Oliveira, Luciana Márcia de Pedrosa, André Luiz Ueira-Vieira, Carlos Guimarães, Claudia Teixeira Bartholomeu, Daniela C. Oliveira, Magalhães de Santos, Fabrício R. Rabelo, Élida Mara Lobo, Francisco Pereira Franco, Gloria Regina Costa, Ana Flávia Castro, Ieso M. Dias, Sílvia Regina Costa Ferro, Jesus Aparecido Ortega, José Miguel Paiva, Luciano Vilela Goulart Filho, Luiz Ricardo Almeida, Juliana Franco Ferro, Maria Inês Tiraboschi Carneiro, Newton Portilho Falcão, Paula Regina Kuser Grynberg, Priscila Teixeira, Santuza Maria Ribeiro Brommonschenkel, Sérgio Oliveira, Sérgio Costa Nascimento, Roberto José Meyer Moore, Robert J. Miyoshi, Anderson Oliveira, Guilherme C. Azevedo, Vasco Ariston de Carvalho Ruiz, Jerônimo Conceição Ferreira, Vívian D'Afonseca da Silva Silva, Artur Luiz da Costa da Ali, Amjad Pinto, Anne Cybelle Santos, Anderson Rodrigues dos Rocha, Aryane Aparecida Magalhães Cassiano Lopes, Débora de Oliveira Dorella, Fernanda Alves Pacheco, Luis Gustavo Carvalho Costa, Marcilia Pinheiro da Turk, Meritxell Zurita Seyffert, Núbia Moraes, Pablo Matias Ribeiro de Oliveira Soares, Siomar de Castro Almeida, Sintia Silva de Castro, Thiago Luiz de Paula Abreu, Vinicius Augusto Carvalho de Trost, Eva Baumbach, Jan Tauch, Andreas Schneider, Maria Paula Cruz McCulloch, John Anthony Cerdeira, Louise Teixeira Ramos, Rommel Thiago Juca Zerlotini, Adhemar Dominitini, Anderson Resende, Daniela de Melo Coser, Elisângela Monteiro Oliveira, Luciana Márcia de Pedrosa, André Luiz Ueira-Vieira, Carlos Guimarães, Claudia Teixeira Bartholomeu, Daniela C. Oliveira, Magalhães de Santos, Fabrício R. Rabelo, Élida Mara Lobo, Francisco Pereira Franco, Gloria Regina Costa, Ana Flávia Castro, Ieso M. Dias, Sílvia Regina Costa Ferro, Jesus Aparecido Ortega, José Miguel Paiva, Luciano Vilela Goulart Filho, Luiz Ricardo Almeida, Juliana Franco Ferro, Maria Inês Tiraboschi Carneiro, Newton Portilho Falcão, Paula Regina Kuser Grynberg, Priscila Teixeira, Santuza Maria Ribeiro Brommonschenkel, Sérgio Oliveira, Sérgio Costa Nascimento, Roberto José Meyer Moore, Robert J. Miyoshi, Anderson Oliveira, Guilherme C. Azevedo, Vasco Ariston de Carvalho |
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p. 1-15 |
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2011 |
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2011 |
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2012-02-27T13:03:23Z |
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1932-6203 |
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v. 6, n. 4. |
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1932-6203 v. 6, n. 4. |
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DOI: 10.1371/journal.pone.0018551 |
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