Networking the host immune response in Plasmodium vivax malaria

Detalhes bibliográficos
Autor(a) principal: Mendonça, Vitor Rosa Ramos de
Data de Publicação: 2013
Outros Autores: Queiroz, Artur T. L., Lopes, Fabrício M., Andrade, Bruno Bezerril, Barral-Netto, Manoel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/12428
Resumo: p. 1-10
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spelling Mendonça, Vitor Rosa Ramos deQueiroz, Artur T. L.Lopes, Fabrício M.Andrade, Bruno BezerrilBarral-Netto, ManoelMendonça, Vitor Rosa Ramos deQueiroz, Artur T. L.Lopes, Fabrício M.Andrade, Bruno BezerrilBarral-Netto, Manoel2013-08-05T01:20:47Z2013-08-05T01:20:47Z20131475-2875http://www.repositorio.ufba.br/ri/handle/ri/12428v. 12, n. 69p. 1-10Background: Plasmodium vivax malaria clinical outcomes are a consequence of the interaction of multiple parasite, environmental and host factors. The host molecular and genetic determinants driving susceptibility to disease severity in this infection are largely unknown. Here, a network analysis of large-scale data from a significant number of individuals with different clinical presentations of P. vivax malaria was performed in an attempt to identify patterns of association between various candidate biomarkers and the clinical outcomes. Methods: A retrospective analysis of 530 individuals from the Brazilian Amazon, including P. vivax-infected individuals who developed different clinical outcomes (148 asymptomatic malaria, 187 symptomatic malaria, 13 severe non-lethal malaria, and six severe lethal malaria) as well as 176 non-infected controls, was performed. Plasma levels of liver transaminases, bilirubins, creatinine, fibrinogen, C-reactive protein, superoxide dismutase (SOD)-1, haem oxygenase (HO)-1 and a panel composed by multiple cytokines and chemokines were measured and compared between the different clinical groups using network analysis. Results: Non-infected individuals displayed several statistically significant interactions in the networks, including associations between the levels of IL-10 and IL-4 with the chemokine CXCL9. Individuals with asymptomatic malaria displayed multiple significant interactions involving IL-4. Subjects with mild or severe non-lethal malaria displayed substantial loss of interactions in the networks and TNF had significant associations more frequently with other parameters. Cases of lethal P. vivax malaria infection were associated with significant interactions between TNF ALT, HO-1 and SOD-1. Conclusions: The findings imply that clinical immunity to P. vivax malaria is associated with multiple significant interactions in the network, mostly involving IL-4, while lethality is linked to a systematic reduction of complexity of these interactions and to an increase in connections between markers linked to haemolysis-induced damage.Submitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2013-07-01T19:53:36Z No. of bitstreams: 1 66666666666666.pdf: 537181 bytes, checksum: 7093567975f257961a6e78654dc209de (MD5)Approved for entry into archive by Flávia Ferreira(flaviaccf@yahoo.com.br) on 2013-08-05T01:20:47Z (GMT) No. of bitstreams: 1 66666666666666.pdf: 537181 bytes, checksum: 7093567975f257961a6e78654dc209de (MD5)Made available in DSpace on 2013-08-05T01:20:47Z (GMT). No. of bitstreams: 1 66666666666666.pdf: 537181 bytes, checksum: 7093567975f257961a6e78654dc209de (MD5) Previous issue date: 2013SalvadorMalaria Journal10.1186/1475-2875-12-69reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAMalariaPlasmodium vivaxBiomarkersNetwork analysisNetworking the host immune response in Plasmodium vivax malariaMalaria Journalinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessORIGINAL66666666666666.pdf66666666666666.pdfapplication/pdf537181https://repositorio.ufba.br/bitstream/ri/12428/1/66666666666666.pdf7093567975f257961a6e78654dc209deMD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/12428/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXT66666666666666.pdf.txt66666666666666.pdf.txtExtracted texttext/plain51097https://repositorio.ufba.br/bitstream/ri/12428/3/66666666666666.pdf.txtb09a03c3f1943a3e33324197ec0cab0eMD53ri/124282022-07-05 14:02:51.454oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:02:51Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Networking the host immune response in Plasmodium vivax malaria
dc.title.alternative.pt_BR.fl_str_mv Malaria Journal
title Networking the host immune response in Plasmodium vivax malaria
spellingShingle Networking the host immune response in Plasmodium vivax malaria
Mendonça, Vitor Rosa Ramos de
Malaria
Plasmodium vivax
Biomarkers
Network analysis
title_short Networking the host immune response in Plasmodium vivax malaria
title_full Networking the host immune response in Plasmodium vivax malaria
title_fullStr Networking the host immune response in Plasmodium vivax malaria
title_full_unstemmed Networking the host immune response in Plasmodium vivax malaria
title_sort Networking the host immune response in Plasmodium vivax malaria
author Mendonça, Vitor Rosa Ramos de
author_facet Mendonça, Vitor Rosa Ramos de
Queiroz, Artur T. L.
Lopes, Fabrício M.
Andrade, Bruno Bezerril
Barral-Netto, Manoel
author_role author
author2 Queiroz, Artur T. L.
Lopes, Fabrício M.
Andrade, Bruno Bezerril
Barral-Netto, Manoel
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Mendonça, Vitor Rosa Ramos de
Queiroz, Artur T. L.
Lopes, Fabrício M.
Andrade, Bruno Bezerril
Barral-Netto, Manoel
Mendonça, Vitor Rosa Ramos de
Queiroz, Artur T. L.
Lopes, Fabrício M.
Andrade, Bruno Bezerril
Barral-Netto, Manoel
dc.subject.por.fl_str_mv Malaria
Plasmodium vivax
Biomarkers
Network analysis
topic Malaria
Plasmodium vivax
Biomarkers
Network analysis
description p. 1-10
publishDate 2013
dc.date.accessioned.fl_str_mv 2013-08-05T01:20:47Z
dc.date.available.fl_str_mv 2013-08-05T01:20:47Z
dc.date.issued.fl_str_mv 2013
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/12428
dc.identifier.issn.none.fl_str_mv 1475-2875
dc.identifier.number.pt_BR.fl_str_mv v. 12, n. 69
identifier_str_mv 1475-2875
v. 12, n. 69
url http://www.repositorio.ufba.br/ri/handle/ri/12428
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Malaria Journal
publisher.none.fl_str_mv Malaria Journal
dc.source.pt_BR.fl_str_mv 10.1186/1475-2875-12-69
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
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