Association of matrix metalloproteinase gene polymorphism with temporomandibular joint degeneration

Detalhes bibliográficos
Autor(a) principal: Planello, Aline C.
Data de Publicação: 2011
Outros Autores: Campos, Maria Isabela Guimarães, Meloto, Carolina B., Secolin, Rodrigo, Rizatti-Barbosa, Célia M., Line, Sergio R. P., Souza, Ana P. de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/5549
Resumo: Acesso restrito: Texto completo. p. 1-6
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spelling Planello, Aline C.Campos, Maria Isabela GuimarãesMeloto, Carolina B.Secolin, RodrigoRizatti-Barbosa, Célia M.Line, Sergio R. P.Souza, Ana P. dePlanello, Aline C.Campos, Maria Isabela GuimarãesMeloto, Carolina B.Secolin, RodrigoRizatti-Barbosa, Célia M.Line, Sergio R. P.Souza, Ana P. de2012-03-21T19:12:46Z2011-020909-8836http://www.repositorio.ufba.br/ri/handle/ri/5549v. 119, n. 1Acesso restrito: Texto completo. p. 1-6Temporomandibular joint (TMJ) degeneration is a frequent cause of orofacial pain. Matrix metalloproteinases (MMPs) degrade extracellular matrix components and play an important role in TMJ degeneration. We investigated the frequency of the MMP1 1G/2G polymorphism (rs1799750), the MMP3 5A/6A polymorphism (rs3025058), and the MMP9 C/T polymorphism (rs3918242) in individuals with TMJ degeneration, in order to analyze the association of polymorphisms in these genes with TMJ degeneration. The population studied comprised 117 healthy controls and 115 individuals diagnosed with TMJ degeneration upon examination of magnetic resonance imaging (MRI) and computed tomography (CT) images. Genotypes were determined using PCR restriction fragment length polymorphism (RFLP). Logistic regression analyses revealed an association between the MMP1 2G/2G genotype and degeneration; in contrast, there was no association between either the MMP3 or the MMP9 genotype and degeneration. Our results may indicate a role for the MMP1 polymorphism in TMJ degeneration.Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2012-03-21T19:12:46Z No. of bitstreams: 1 __onlinelibrary.wiley.co...614c947b69b27b9c2c63cb414765b.pdf: 135013 bytes, checksum: 6f7d48b53762a4279c823515356397c5 (MD5)Made available in DSpace on 2012-03-21T19:12:46Z (GMT). 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dc.title.pt_BR.fl_str_mv Association of matrix metalloproteinase gene polymorphism with temporomandibular joint degeneration
dc.title.alternative.pt_BR.fl_str_mv European Journal of Oral Sciences
title Association of matrix metalloproteinase gene polymorphism with temporomandibular joint degeneration
spellingShingle Association of matrix metalloproteinase gene polymorphism with temporomandibular joint degeneration
Planello, Aline C.
Genetic polymorphism
Matrix metalloproteinase
Single nucleotide polymorphism
Temporomandibular joint
title_short Association of matrix metalloproteinase gene polymorphism with temporomandibular joint degeneration
title_full Association of matrix metalloproteinase gene polymorphism with temporomandibular joint degeneration
title_fullStr Association of matrix metalloproteinase gene polymorphism with temporomandibular joint degeneration
title_full_unstemmed Association of matrix metalloproteinase gene polymorphism with temporomandibular joint degeneration
title_sort Association of matrix metalloproteinase gene polymorphism with temporomandibular joint degeneration
author Planello, Aline C.
author_facet Planello, Aline C.
Campos, Maria Isabela Guimarães
Meloto, Carolina B.
Secolin, Rodrigo
Rizatti-Barbosa, Célia M.
Line, Sergio R. P.
Souza, Ana P. de
author_role author
author2 Campos, Maria Isabela Guimarães
Meloto, Carolina B.
Secolin, Rodrigo
Rizatti-Barbosa, Célia M.
Line, Sergio R. P.
Souza, Ana P. de
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Planello, Aline C.
Campos, Maria Isabela Guimarães
Meloto, Carolina B.
Secolin, Rodrigo
Rizatti-Barbosa, Célia M.
Line, Sergio R. P.
Souza, Ana P. de
Planello, Aline C.
Campos, Maria Isabela Guimarães
Meloto, Carolina B.
Secolin, Rodrigo
Rizatti-Barbosa, Célia M.
Line, Sergio R. P.
Souza, Ana P. de
dc.subject.por.fl_str_mv Genetic polymorphism
Matrix metalloproteinase
Single nucleotide polymorphism
Temporomandibular joint
topic Genetic polymorphism
Matrix metalloproteinase
Single nucleotide polymorphism
Temporomandibular joint
description Acesso restrito: Texto completo. p. 1-6
publishDate 2011
dc.date.issued.fl_str_mv 2011-02
dc.date.accessioned.fl_str_mv 2012-03-21T19:12:46Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/5549
dc.identifier.issn.none.fl_str_mv 0909-8836
dc.identifier.number.pt_BR.fl_str_mv v. 119, n. 1
identifier_str_mv 0909-8836
v. 119, n. 1
url http://www.repositorio.ufba.br/ri/handle/ri/5549
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv DOI: 10.1111/j.1600-0722.2010.00803.x
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
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instname_str Universidade Federal da Bahia (UFBA)
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