Recombination dynamics of human parechoviruses: investigation of type-specific differences in frequency and epidemiological correlates

Detalhes bibliográficos
Autor(a) principal: Calvert, J.
Data de Publicação: 2010
Outros Autores: Chieochansin, T., Benschop, K. S., Leitch, E. C. McWilliam, Drexler, Jan Felix, Grywna, K., Ribeiro Jr, H. da Costa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/13641
Resumo: Texto completo: acesso restrito. p.1229-1238
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spelling Calvert, J.Chieochansin, T.Benschop, K. S.Leitch, E. C. McWilliamDrexler, Jan FelixGrywna, K.Ribeiro Jr, H. da CostaCalvert, J.Chieochansin, T.Benschop, K. S.Leitch, E. C. McWilliamDrexler, Jan FelixGrywna, K.Ribeiro Jr, H. da Costa2013-11-14T20:00:05Z20100022-1317http://repositorio.ufba.br/ri/handle/ri/13641v. 91, n. 5Texto completo: acesso restrito. p.1229-1238Human parechoviruses (HPeVs) are highly prevalent RNA viruses classified in the family Picornaviridae. Several antigenically distinct types circulate in human populations worldwide, whilst recombination additionally contributes to the genetic heterogeneity of the virus. To investigate factors influencing the likelihood of recombination and to compare its dynamics among types, 154 variants collected from four widely geographically separated referral centres (UK, The Netherlands, Thailand and Brazil) were typed by VP3/VP1 amplification/sequencing with recombination groups assigned by analysis of 3Dpol sequences. HPeV1B and HPeV3 were the most frequently detected types in each referral region, but with marked geographical differences in the frequencies of different recombinant forms (RFs) of types 1B, 5 and 6. HPeV1B showed more frequent recombination than HPeV3, in terms both of evolutionary divergence and of temporal/geographical indicators of population separation. HPeV1 variants showing between 10 and 20 % divergence in VP3/VP1 almost invariably fell into different recombination groups, compared with only one-third of similarly divergent HPeV3 variants. Substitution rates calculated by beast in the VP3/VP1 region of HPeV1 and HPeV3 allowed half-lives of the RFs of 4 and 20 years, respectively, to be calculated, estimates fitting closely with their observed lifespans based on population sampling. The variability in recombination dynamics between HPeV1B and HPeV3 offers an intriguing link with their markedly different seasonal patterns of transmission, age distributions of infection and clinical outcomes. Future investigation of the epidemiological and biological opportunities and constraints on intertypic recombination will provide more information about its influence on the longer term evolution and pathogenicity of parechoviruses.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-08-29T17:58:22Z No. of bitstreams: 1 J. Calvert1229.full.pdf: 743278 bytes, checksum: 7ccbb5fcb7c322235854458312c0b7da (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2013-11-14T20:00:04Z (GMT) No. of bitstreams: 1 J. Calvert1229.full.pdf: 743278 bytes, checksum: 7ccbb5fcb7c322235854458312c0b7da (MD5)Made available in DSpace on 2013-11-14T20:00:05Z (GMT). No. of bitstreams: 1 J. Calvert1229.full.pdf: 743278 bytes, checksum: 7ccbb5fcb7c322235854458312c0b7da (MD5) Previous issue date: 2010http://dx.doi.org/10.1099/vir.0.018747-0reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBARecombination dynamics of human parechoviruses: investigation of type-specific differences in frequency and epidemiological correlatesJournal of General Virologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINALJ. Calvert1229.full.pdfJ. Calvert1229.full.pdfapplication/pdf743278https://repositorio.ufba.br/bitstream/ri/13641/1/J.%20Calvert1229.full.pdf7ccbb5fcb7c322235854458312c0b7daMD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/13641/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTJ. Calvert1229.full.pdf.txtJ. 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dc.title.pt_BR.fl_str_mv Recombination dynamics of human parechoviruses: investigation of type-specific differences in frequency and epidemiological correlates
dc.title.alternative.pt_BR.fl_str_mv Journal of General Virology
title Recombination dynamics of human parechoviruses: investigation of type-specific differences in frequency and epidemiological correlates
spellingShingle Recombination dynamics of human parechoviruses: investigation of type-specific differences in frequency and epidemiological correlates
Calvert, J.
title_short Recombination dynamics of human parechoviruses: investigation of type-specific differences in frequency and epidemiological correlates
title_full Recombination dynamics of human parechoviruses: investigation of type-specific differences in frequency and epidemiological correlates
title_fullStr Recombination dynamics of human parechoviruses: investigation of type-specific differences in frequency and epidemiological correlates
title_full_unstemmed Recombination dynamics of human parechoviruses: investigation of type-specific differences in frequency and epidemiological correlates
title_sort Recombination dynamics of human parechoviruses: investigation of type-specific differences in frequency and epidemiological correlates
author Calvert, J.
author_facet Calvert, J.
Chieochansin, T.
Benschop, K. S.
Leitch, E. C. McWilliam
Drexler, Jan Felix
Grywna, K.
Ribeiro Jr, H. da Costa
author_role author
author2 Chieochansin, T.
Benschop, K. S.
Leitch, E. C. McWilliam
Drexler, Jan Felix
Grywna, K.
Ribeiro Jr, H. da Costa
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Calvert, J.
Chieochansin, T.
Benschop, K. S.
Leitch, E. C. McWilliam
Drexler, Jan Felix
Grywna, K.
Ribeiro Jr, H. da Costa
Calvert, J.
Chieochansin, T.
Benschop, K. S.
Leitch, E. C. McWilliam
Drexler, Jan Felix
Grywna, K.
Ribeiro Jr, H. da Costa
description Texto completo: acesso restrito. p.1229-1238
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2013-11-14T20:00:05Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/13641
dc.identifier.issn.none.fl_str_mv 0022-1317
dc.identifier.number.pt_BR.fl_str_mv v. 91, n. 5
identifier_str_mv 0022-1317
v. 91, n. 5
url http://repositorio.ufba.br/ri/handle/ri/13641
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1099/vir.0.018747-0
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