Exposure of Phosphatidylserine on Leishmania amazonensis Isolates Is Associated with Diffuse Cutaneous Leishmaniasis and Parasite Infectivity

Detalhes bibliográficos
Autor(a) principal: Costa, Jaqueline França
Data de Publicação: 2012
Outros Autores: Wanderley, João Luiz Mendes, Deolindo, Poliana, Zarattini, Jessica Bevilaqua, Costa, Jackson, Soong, Lynn, Barcinski, Marcello André, Barral, Aldina Maria Prado, Borges, Valéria de Matos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/16363
Resumo: p. 1-10
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spelling Costa, Jaqueline FrançaWanderley, João Luiz MendesDeolindo, PolianaZarattini, Jessica BevilaquaCosta, JacksonSoong, LynnBarcinski, Marcello AndréBarral, Aldina Maria PradoBorges, Valéria de Matos2014-10-09T15:55:54Z2014-10-09T15:55:54Z20121932-6203http://repositorio.ufba.br/ri/handle/ri/16363v. 7, n. 5p. 1-10Diffuse cutaneous leishmaniasis (DCL) is a rare clinical manifestation of leishmaniasis, characterized by an inefficient parasite-specific cellular response and heavily parasitized macrophages. In Brazil, Leishmania (Leishmania) amazonensis is the main species involved in DCL cases. In the experimental model, recognition of phosphatidylserine (PS) molecules exposed on the surface of amastigotes forms of L. amazonensis inhibits the inflammatory response of infected macrophages as a strategy to evade the host immune surveillance. In this study, we examined whether PS exposure on L. amazonensis isolates from DCL patients operated as a parasite pathogenic factor and as a putative suppression mechanism of immune response during the infection. Peritoneal macrophages from F1 mice (BALB/c×C57BL/6) were infected with different L. amazonensis isolates from patients with localized cutaneous leishmaniasis (LCL) or DCL. DCL isolates showed higher PS exposure than their counterparts from LCL patients. In addition, PS exposure was positively correlated with clinical parameters of the human infection (number of lesions and time of disease) and with characteristics of the experimental infection (macrophage infection and anti-inflammatory cytokine induction). Furthermore, parasites isolated from DCL patients displayed an increased area in parasitophorous vacuoles (PV) when compared to those isolated from LCL patients. Thus, this study shows for the first time that a parasite factor (exposed PS) might be associated with parasite survival/persistence in macrophages and lesion exacerbation during the course of DCL, providing new insights regarding pathogenic mechanism in this rare chronic disease.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-08-11T13:08:17Z No. of bitstreams: 1 Jaqueline França Costa.pdf: 412815 bytes, checksum: 53fe07189ee39eaf55c4db8771b86315 (MD5)Approved for entry into archive by Delba Rosa (delba@ufba.br) on 2014-10-09T15:55:54Z (GMT) No. of bitstreams: 1 Jaqueline França Costa.pdf: 412815 bytes, checksum: 53fe07189ee39eaf55c4db8771b86315 (MD5)Made available in DSpace on 2014-10-09T15:55:54Z (GMT). No. of bitstreams: 1 Jaqueline França Costa.pdf: 412815 bytes, checksum: 53fe07189ee39eaf55c4db8771b86315 (MD5) Previous issue date: 2012http://dx.doi.org/ 10.1371/journal.pone.0036595reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAExposure of Phosphatidylserine on Leishmania amazonensis Isolates Is Associated with Diffuse Cutaneous Leishmaniasis and Parasite InfectivityPLoS ONEinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleBrasilinfo:eu-repo/semantics/openAccessengORIGINALJaqueline França Costa.pdfJaqueline França Costa.pdfapplication/pdf412815https://repositorio.ufba.br/bitstream/ri/16363/1/Jaqueline%20Fran%c3%a7a%20Costa.pdf53fe07189ee39eaf55c4db8771b86315MD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/16363/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXTJaqueline França Costa.pdf.txtJaqueline França Costa.pdf.txtExtracted texttext/plain52554https://repositorio.ufba.br/bitstream/ri/16363/3/Jaqueline%20Fran%c3%a7a%20Costa.pdf.txtd46802e8b4c88b198624ea67ead281f5MD53ri/163632022-03-09 20:30:19.458oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-03-09T23:30:19Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Exposure of Phosphatidylserine on Leishmania amazonensis Isolates Is Associated with Diffuse Cutaneous Leishmaniasis and Parasite Infectivity
dc.title.alternative.pt_BR.fl_str_mv PLoS ONE
title Exposure of Phosphatidylserine on Leishmania amazonensis Isolates Is Associated with Diffuse Cutaneous Leishmaniasis and Parasite Infectivity
spellingShingle Exposure of Phosphatidylserine on Leishmania amazonensis Isolates Is Associated with Diffuse Cutaneous Leishmaniasis and Parasite Infectivity
Costa, Jaqueline França
title_short Exposure of Phosphatidylserine on Leishmania amazonensis Isolates Is Associated with Diffuse Cutaneous Leishmaniasis and Parasite Infectivity
title_full Exposure of Phosphatidylserine on Leishmania amazonensis Isolates Is Associated with Diffuse Cutaneous Leishmaniasis and Parasite Infectivity
title_fullStr Exposure of Phosphatidylserine on Leishmania amazonensis Isolates Is Associated with Diffuse Cutaneous Leishmaniasis and Parasite Infectivity
title_full_unstemmed Exposure of Phosphatidylserine on Leishmania amazonensis Isolates Is Associated with Diffuse Cutaneous Leishmaniasis and Parasite Infectivity
title_sort Exposure of Phosphatidylserine on Leishmania amazonensis Isolates Is Associated with Diffuse Cutaneous Leishmaniasis and Parasite Infectivity
author Costa, Jaqueline França
author_facet Costa, Jaqueline França
Wanderley, João Luiz Mendes
Deolindo, Poliana
Zarattini, Jessica Bevilaqua
Costa, Jackson
Soong, Lynn
Barcinski, Marcello André
Barral, Aldina Maria Prado
Borges, Valéria de Matos
author_role author
author2 Wanderley, João Luiz Mendes
Deolindo, Poliana
Zarattini, Jessica Bevilaqua
Costa, Jackson
Soong, Lynn
Barcinski, Marcello André
Barral, Aldina Maria Prado
Borges, Valéria de Matos
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Costa, Jaqueline França
Wanderley, João Luiz Mendes
Deolindo, Poliana
Zarattini, Jessica Bevilaqua
Costa, Jackson
Soong, Lynn
Barcinski, Marcello André
Barral, Aldina Maria Prado
Borges, Valéria de Matos
description p. 1-10
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2014-10-09T15:55:54Z
dc.date.available.fl_str_mv 2014-10-09T15:55:54Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/16363
dc.identifier.issn.none.fl_str_mv 1932-6203
dc.identifier.number.pt_BR.fl_str_mv v. 7, n. 5
identifier_str_mv 1932-6203
v. 7, n. 5
url http://repositorio.ufba.br/ri/handle/ri/16363
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.country.fl_str_mv Brasil
dc.source.pt_BR.fl_str_mv http://dx.doi.org/ 10.1371/journal.pone.0036595
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