Saliva from Lutzomyia longipalpis Induces CC Chemokine Ligand 2/Monocyte Chemoattractant Protein-1 Expression and Macrophage Recruitment
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2005 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/13497 |
Resumo: | Texto completo: acesso restrito.p.8346-8353 |
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Teixeira, Clarissa RomeroTeixeira, Maria JaniaGomes, Regis Bernardo BrandimSantos, Claire da SilvaAndrade, Bruno BezerrilRaffaele-Netto, ImbroiniseSilva, João Santana daGuglielmotti, AngeloMiranda, José CarlosBarral, Aldina Maria PradoBrodskyn, Claudia IdaBarral-Netto, ManoelTeixeira, Clarissa RomeroTeixeira, Maria JaniaGomes, Regis Bernardo BrandimSantos, Claire da SilvaAndrade, Bruno BezerrilRaffaele-Netto, ImbroiniseSilva, João Santana daGuglielmotti, AngeloMiranda, José CarlosBarral, Aldina Maria PradoBrodskyn, Claudia IdaBarral-Netto, Manoel2013-11-01T19:26:05Z20050022-1767http://repositorio.ufba.br/ri/handle/ri/13497v.25 n. 65Texto completo: acesso restrito.p.8346-8353Saliva of bloodfeeding arthropods has been incriminated in facilitating the establishment of parasite in their host. We report on the leukocyte chemoattractive effect of salivary gland homogenate (SGH) from Lutzomyia longipalpis on saliva-induced inflammation in an air pouch model. SGH (0.5 pair/animal) was inoculated in the air pouch formed in the back of BALB/c or C57BL/6 mice. L. longipalpis SGH induced a significant influx of macrophages in BALB/c but not in C57BL/6 mice. SGH-induced cell recruitment reached a peak at 12 h after inoculation and was higher than that induced by the LPS control. This differential cell recruitment in BALB/c mice was directly correlated to an increase in CCL2/MCP-1 expression in the air pouch lining tissue. In fact, treatment with bindarit, an inhibitor of CCL2/MCP-1 synthesis, and also with a specific anti-MCP-1 mAb resulted in drastic reduction of macrophage recruitment and inhibition of CCL2/MCP-1 expression in the lining tissue. CCL2/MCP-1 production was also seen in vitro when J774 murine macrophages were exposed to L. longipalpis SGH. The SGH effect was abrogated by preincubation with serum containing anti-SGH IgG Abs as well as in mice previously sensitized with L. longipalpis bites. Interestingly, the combination of SGH with Leishmania chagasi induced an increased recruitment of neutrophils and macrophages when compared with L. chagasi alone. Taken together these results suggest that SGH not only induces the recruitment of a greater number of macrophages by enhancing CCL2/MCP-1 production but also synergizes with L. chagasi to recruit more inflammatory cells to the site of inoculation.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2013-09-09T15:49:13Z No. of bitstreams: 1 8346.full.pdf: 855486 bytes, checksum: 1c7d51f5819eb413b86382dd03c13a0b (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2013-11-01T19:26:05Z (GMT) No. of bitstreams: 1 8346.full.pdf: 855486 bytes, checksum: 1c7d51f5819eb413b86382dd03c13a0b (MD5)Made available in DSpace on 2013-11-01T19:26:05Z (GMT). No. of bitstreams: 1 8346.full.pdf: 855486 bytes, checksum: 1c7d51f5819eb413b86382dd03c13a0b (MD5) Previous issue date: 2005http://www-jimmunol-org.ez10.periodicos.capes.gov.br/content/175/12/8346.full.pdf+htmlreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBASaliva from Lutzomyia longipalpis Induces CC Chemokine Ligand 2/Monocyte Chemoattractant Protein-1 Expression and Macrophage RecruitmentJournal of Immunologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengLICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/13497/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52ORIGINAL8346.full.pdf8346.full.pdfapplication/pdf855486https://repositorio.ufba.br/bitstream/ri/13497/1/8346.full.pdf1c7d51f5819eb413b86382dd03c13a0bMD51TEXT8346.full.pdf.txt8346.full.pdf.txtExtracted texttext/plain46048https://repositorio.ufba.br/bitstream/ri/13497/3/8346.full.pdf.txtd3185604f26fd8e2c2b8688750a7950aMD53ri/134972022-07-05 14:03:46.601oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:46Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Saliva from Lutzomyia longipalpis Induces CC Chemokine Ligand 2/Monocyte Chemoattractant Protein-1 Expression and Macrophage Recruitment |
| dc.title.alternative.pt_BR.fl_str_mv |
Journal of Immunology |
| title |
Saliva from Lutzomyia longipalpis Induces CC Chemokine Ligand 2/Monocyte Chemoattractant Protein-1 Expression and Macrophage Recruitment |
| spellingShingle |
Saliva from Lutzomyia longipalpis Induces CC Chemokine Ligand 2/Monocyte Chemoattractant Protein-1 Expression and Macrophage Recruitment Teixeira, Clarissa Romero |
| title_short |
Saliva from Lutzomyia longipalpis Induces CC Chemokine Ligand 2/Monocyte Chemoattractant Protein-1 Expression and Macrophage Recruitment |
| title_full |
Saliva from Lutzomyia longipalpis Induces CC Chemokine Ligand 2/Monocyte Chemoattractant Protein-1 Expression and Macrophage Recruitment |
| title_fullStr |
Saliva from Lutzomyia longipalpis Induces CC Chemokine Ligand 2/Monocyte Chemoattractant Protein-1 Expression and Macrophage Recruitment |
| title_full_unstemmed |
Saliva from Lutzomyia longipalpis Induces CC Chemokine Ligand 2/Monocyte Chemoattractant Protein-1 Expression and Macrophage Recruitment |
| title_sort |
Saliva from Lutzomyia longipalpis Induces CC Chemokine Ligand 2/Monocyte Chemoattractant Protein-1 Expression and Macrophage Recruitment |
| author |
Teixeira, Clarissa Romero |
| author_facet |
Teixeira, Clarissa Romero Teixeira, Maria Jania Gomes, Regis Bernardo Brandim Santos, Claire da Silva Andrade, Bruno Bezerril Raffaele-Netto, Imbroinise Silva, João Santana da Guglielmotti, Angelo Miranda, José Carlos Barral, Aldina Maria Prado Brodskyn, Claudia Ida Barral-Netto, Manoel |
| author_role |
author |
| author2 |
Teixeira, Maria Jania Gomes, Regis Bernardo Brandim Santos, Claire da Silva Andrade, Bruno Bezerril Raffaele-Netto, Imbroinise Silva, João Santana da Guglielmotti, Angelo Miranda, José Carlos Barral, Aldina Maria Prado Brodskyn, Claudia Ida Barral-Netto, Manoel |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Teixeira, Clarissa Romero Teixeira, Maria Jania Gomes, Regis Bernardo Brandim Santos, Claire da Silva Andrade, Bruno Bezerril Raffaele-Netto, Imbroinise Silva, João Santana da Guglielmotti, Angelo Miranda, José Carlos Barral, Aldina Maria Prado Brodskyn, Claudia Ida Barral-Netto, Manoel Teixeira, Clarissa Romero Teixeira, Maria Jania Gomes, Regis Bernardo Brandim Santos, Claire da Silva Andrade, Bruno Bezerril Raffaele-Netto, Imbroinise Silva, João Santana da Guglielmotti, Angelo Miranda, José Carlos Barral, Aldina Maria Prado Brodskyn, Claudia Ida Barral-Netto, Manoel |
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Texto completo: acesso restrito.p.8346-8353 |
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2005 |
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2005 |
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2013-11-01T19:26:05Z |
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0022-1767 |
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v.25 n. 65 |
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0022-1767 v.25 n. 65 |
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