Lutzomyia longipalpis Saliva Induces Heme Oxygenase-1 Expression at Bite Sites
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/30695 |
Resumo: | Fundação de Amparo a Pesquisa do Estado da Bahia (FAPESB) e Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), and by the Intramural Research Program of the NIH, National Institute of Allergy and Infectious Diseases. This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) - Finance Code 001. NL is a fellowship recipient from CAPES Brazil; PM is a fellowship recipient from FAPESB; AV is a fellowship recipient from Programa Nacional de Pós-Doutorado/CAPES; CdO, UL, CB and VMB are senior investigators of CNPq. |
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Luz, Nívea FariasVieira, Thiago de SouzaCastro, Waldione deVivarini, Aislan de CarvalhoPereira, LaisFrança, Riam RochaMattos, Paulo Sérgio de Morais da SilveiraCosta, Diego LuisTeixeira, ClarissaMeneses, ClaudioBoaventura, Viviane SampaioOliveira, Camila Indiani deLopes, Ulisses GazosAronson, NaomiAndrade, Bruno de BezerrilBrodskyn, Claudia IdaValenzuela, Jesus G.Kamhawi, ShadenBorges, Valeria de Matos2018-12-19T16:46:42Z2018-12-19T16:46:42Z2018LUZ, Nívea Farias et al. Lutzomyia longipalpis saliva induces heme oxygenase-1 expression at bite sites. Frontiers in Immunology, v. 9, p. 1-10, Nov. 2018.1664-3224https://www.arca.fiocruz.br/handle/icict/3069510.3389/fimmu.2018.02779Fundação de Amparo a Pesquisa do Estado da Bahia (FAPESB) e Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), and by the Intramural Research Program of the NIH, National Institute of Allergy and Infectious Diseases. This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) - Finance Code 001. NL is a fellowship recipient from CAPES Brazil; PM is a fellowship recipient from FAPESB; AV is a fellowship recipient from Programa Nacional de Pós-Doutorado/CAPES; CdO, UL, CB and VMB are senior investigators of CNPq.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Malaria and Vector Research. Vector Molecular Biology Section. Rockville, MD, United States.National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Malaria and Vector Research. Vector Molecular Biology Section. Rockville, MD, USA.Federal University of Rio de Janeiro. Carlos Chagas Filho Biophysics Institute. Laboratory of Molecular Parasitology, Center of Health Science. Rio de Janeiro, RJ, Brazil.National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Malaria and Vector Research. Vector Molecular Biology Section. Rockville, MD, USA.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Parasitic Diseases, Immunobiology Section. Bethesda, MD, USA.Fundação Oswaldo Cruz. Teresina, PI, Brasil.National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Malaria and Vector Research. Vector Molecular Biology Section. Rockville, MD, USA.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Federal University of Rio de Janeiro. Carlos Chagas Filho Biophysics Institute. Laboratory of Molecular Parasitology, Center of Health Science. Rio de Janeiro, RJ, Brazil.Uniformed Services University of the Health Sciences. Infectious Diseases Division. Bethesda, MD, USA.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Fundação José Silveira, Bahia. Multinational Organization Network Sponsoring Translational and Epidemiological Research. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Malaria and Vector Research. Vector Molecular Biology Section. Rockville, MD, USA.National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Malaria and Vector Research. Vector Molecular Biology Section. Rockville, MD, United States.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Sand flies bite mammalian hosts to obtain a blood meal, driving changes in the host inflammatory response that support the establishment of Leishmania infection. This effect is partially attributed to components of sand fly saliva, which are able to recruit and activate leukocytes. Our group has shown that heme oxygenase-1 (HO-1) favors Leishmania survival in infected cells by reducing inflammatory responses. Here, we show that exposure to sand fly bites is associated with induction of HO-1 in vivo. Histopathological analyses of skin specimens from human volunteers experimentally exposed to sand fly bites revealed that HO-1 and Nrf2 are produced at bite sites in the skin. These results were recapitulated in mice ears injected with a salivary gland sonicate (SGS) or exposed to sand fly bites, indicating that vector saliva may be a key factor in triggering HO-1 expression. Resident skin macrophages were the main source HO-1 at 24-48 h after bites. Additionally, assays in vivo after bites and in vitro after stimulation with saliva both demonstrated that HO-1 production by macrophages was Nrf2-dependent. Collectively, our data demonstrates that vector saliva induces early HO-1 production at the bite sites, representing a major event associated with establishment of naturally-transmitted Leishmania infections.engFrontiers MediaLutzomyia longipalpisMosca da areiaSalivaPeleMacrófagosHeme oxigenase-1Nrf2Lutzomyia longipalpisSand fly biteSalivaSkinMacrophagesHeme oxygenase-1Nrf2Lutzomyia longipalpis Saliva Induces Heme Oxygenase-1 Expression at Bite Sitesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/30695/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALLuz NF. Lutzomyia longipalpis saliva...2018.pdfLuz NF. 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| dc.title.pt_BR.fl_str_mv |
Lutzomyia longipalpis Saliva Induces Heme Oxygenase-1 Expression at Bite Sites |
| title |
Lutzomyia longipalpis Saliva Induces Heme Oxygenase-1 Expression at Bite Sites |
| spellingShingle |
Lutzomyia longipalpis Saliva Induces Heme Oxygenase-1 Expression at Bite Sites Luz, Nívea Farias Lutzomyia longipalpis Mosca da areia Saliva Pele Macrófagos Heme oxigenase-1 Nrf2 Lutzomyia longipalpis Sand fly bite Saliva Skin Macrophages Heme oxygenase-1 Nrf2 |
| title_short |
Lutzomyia longipalpis Saliva Induces Heme Oxygenase-1 Expression at Bite Sites |
| title_full |
Lutzomyia longipalpis Saliva Induces Heme Oxygenase-1 Expression at Bite Sites |
| title_fullStr |
Lutzomyia longipalpis Saliva Induces Heme Oxygenase-1 Expression at Bite Sites |
| title_full_unstemmed |
Lutzomyia longipalpis Saliva Induces Heme Oxygenase-1 Expression at Bite Sites |
| title_sort |
Lutzomyia longipalpis Saliva Induces Heme Oxygenase-1 Expression at Bite Sites |
| author |
Luz, Nívea Farias |
| author_facet |
Luz, Nívea Farias Vieira, Thiago de Souza Castro, Waldione de Vivarini, Aislan de Carvalho Pereira, Lais França, Riam Rocha Mattos, Paulo Sérgio de Morais da Silveira Costa, Diego Luis Teixeira, Clarissa Meneses, Claudio Boaventura, Viviane Sampaio Oliveira, Camila Indiani de Lopes, Ulisses Gazos Aronson, Naomi Andrade, Bruno de Bezerril Brodskyn, Claudia Ida Valenzuela, Jesus G. Kamhawi, Shaden Borges, Valeria de Matos |
| author_role |
author |
| author2 |
Vieira, Thiago de Souza Castro, Waldione de Vivarini, Aislan de Carvalho Pereira, Lais França, Riam Rocha Mattos, Paulo Sérgio de Morais da Silveira Costa, Diego Luis Teixeira, Clarissa Meneses, Claudio Boaventura, Viviane Sampaio Oliveira, Camila Indiani de Lopes, Ulisses Gazos Aronson, Naomi Andrade, Bruno de Bezerril Brodskyn, Claudia Ida Valenzuela, Jesus G. Kamhawi, Shaden Borges, Valeria de Matos |
| author2_role |
author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Luz, Nívea Farias Vieira, Thiago de Souza Castro, Waldione de Vivarini, Aislan de Carvalho Pereira, Lais França, Riam Rocha Mattos, Paulo Sérgio de Morais da Silveira Costa, Diego Luis Teixeira, Clarissa Meneses, Claudio Boaventura, Viviane Sampaio Oliveira, Camila Indiani de Lopes, Ulisses Gazos Aronson, Naomi Andrade, Bruno de Bezerril Brodskyn, Claudia Ida Valenzuela, Jesus G. Kamhawi, Shaden Borges, Valeria de Matos |
| dc.subject.other.pt_BR.fl_str_mv |
Lutzomyia longipalpis Mosca da areia Saliva Pele Macrófagos Heme oxigenase-1 Nrf2 |
| topic |
Lutzomyia longipalpis Mosca da areia Saliva Pele Macrófagos Heme oxigenase-1 Nrf2 Lutzomyia longipalpis Sand fly bite Saliva Skin Macrophages Heme oxygenase-1 Nrf2 |
| dc.subject.en.pt_BR.fl_str_mv |
Lutzomyia longipalpis Sand fly bite Saliva Skin Macrophages Heme oxygenase-1 Nrf2 |
| description |
Fundação de Amparo a Pesquisa do Estado da Bahia (FAPESB) e Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), and by the Intramural Research Program of the NIH, National Institute of Allergy and Infectious Diseases. This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) - Finance Code 001. NL is a fellowship recipient from CAPES Brazil; PM is a fellowship recipient from FAPESB; AV is a fellowship recipient from Programa Nacional de Pós-Doutorado/CAPES; CdO, UL, CB and VMB are senior investigators of CNPq. |
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2018 |
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2018-12-19T16:46:42Z |
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2018-12-19T16:46:42Z |
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2018 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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LUZ, Nívea Farias et al. Lutzomyia longipalpis saliva induces heme oxygenase-1 expression at bite sites. Frontiers in Immunology, v. 9, p. 1-10, Nov. 2018. |
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https://www.arca.fiocruz.br/handle/icict/30695 |
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1664-3224 |
| dc.identifier.doi.none.fl_str_mv |
10.3389/fimmu.2018.02779 |
| identifier_str_mv |
LUZ, Nívea Farias et al. Lutzomyia longipalpis saliva induces heme oxygenase-1 expression at bite sites. Frontiers in Immunology, v. 9, p. 1-10, Nov. 2018. 1664-3224 10.3389/fimmu.2018.02779 |
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https://www.arca.fiocruz.br/handle/icict/30695 |
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Frontiers Media |
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Frontiers Media |
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