Balance of IL-10 and Interferon-γ plasma levels in human visceral leishmaniasis: Implications in the pathogenesis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2005 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/13498 |
Resumo: | p.1-9 |
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Barral-Netto, ManoelBarral, Aldina Maria PradoCaldas, Arlene de Jesus MendesFavali, Cecilia Beatriz FiuzaAquino, Dorlene Maria Cardoso deVinhas, Vera Silvia de FreitasWeyenbergh, Johan vanBrodskyn, Claudia IdaJackson Mauricio LopesBarral-Netto, ManoelBarral, Aldina Maria PradoCaldas, Arlene de Jesus MendesFavali, Cecilia Beatriz FiuzaAquino, Dorlene Maria Cardoso deVinhas, Vera Silvia de FreitasWeyenbergh, Johan vanBrodskyn, Claudia IdaJackson Mauricio Lopes2013-11-01T19:26:48Z2013-11-01T19:26:48Z20051471-2334http://repositorio.ufba.br/ri/handle/ri/13498v.5 n. 113p.1-9Background: Leishmaniasis remains a serious public health problem in several parts of the developing world. Effective prophylactic measurements are hampered by imprecise comprehension of different aspects of the disease, including its immunoregulation. A better comprehension of immunoregulation in human VL may be useful both for designing and evaluating immunoprophylaxis. Methods: To explore immunoregulatory mechanisms, 20 visceral leishmaniasis (VL) patients were evaluated during active disease and at different periods up to one year after treatment determining their plasma cytokine levels, clinical parameters (palpable spleen and liver) and antibody levels. Results: Elevated plasma levels of IFN-γ and of IL-12 p40 were observed during active disease, significantly decreasing after treatment whereas in vitro Leishmania antigen-stimulated IFN-γ production by PBMC exhibited an inverse pattern being low during disease and increasing steadily thereafter. Absence of IFN-γ activity is a hallmark of VL. The main candidate for blunting IFN-γ activity is IL-10, a cytokine highly elevated in plasma with sharp decrease after treatment. Activity of IL-10 is inferred by high levels of anti-Leishmania specific IgG1 and IgG3. TGF-β had elevated total, but not of active, levels lessening the likelihood of being the IFN-γ counterpart. Spleen or liver size presented a steady decrease but return to normal values at only 120 days after treatment. Anti-Leishmania IgG (total and subclasses) levels and DTH or Leishmania-stimulated lymphocyte proliferation conversion to positive also present a slow decrease after treatment. IL-6 plasma levels were elevated in only a few patients. Conclusion:Taken together our results suggest that IFN-γ and IL-10 are the molecules most likely involved in determining fate of disease. After treatment, there is a long delay before the immune profile returns to normal what precludes using plasma cytokine levels as criteria of cure as simpler clinical evaluations, as a palpable spleen or liver, can be used.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2013-09-09T15:00:36Z No. of bitstreams: 1 1471-2334-5-113.pdf: 716910 bytes, checksum: 97412173b494bcb490cb197c3fb217c9 (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2013-11-01T19:26:48Z (GMT) No. of bitstreams: 1 1471-2334-5-113.pdf: 716910 bytes, checksum: 97412173b494bcb490cb197c3fb217c9 (MD5)Made available in DSpace on 2013-11-01T19:26:48Z (GMT). No. of bitstreams: 1 1471-2334-5-113.pdf: 716910 bytes, checksum: 97412173b494bcb490cb197c3fb217c9 (MD5) Previous issue date: 2005http://dx.doi.org/ 10.1186/1471-2334-5-113reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBABalance of IL-10 and Interferon-γ plasma levels in human visceral leishmaniasis: Implications in the pathogenesisBMC Infectious Diseasesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessLICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/13498/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52ORIGINAL1471-2334-5-113.pdf1471-2334-5-113.pdfapplication/pdf716910https://repositorio.ufba.br/bitstream/ri/13498/1/1471-2334-5-113.pdf97412173b494bcb490cb197c3fb217c9MD51TEXT1471-2334-5-113.pdf.txt1471-2334-5-113.pdf.txtExtracted texttext/plain38385https://repositorio.ufba.br/bitstream/ri/13498/3/1471-2334-5-113.pdf.txt08a30d85adaaf733e5a8a86cfcd31286MD53ri/134982022-08-08 13:17:35.887oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-08-08T16:17:35Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Balance of IL-10 and Interferon-γ plasma levels in human visceral leishmaniasis: Implications in the pathogenesis |
| dc.title.alternative.pt_BR.fl_str_mv |
BMC Infectious Diseases |
| title |
Balance of IL-10 and Interferon-γ plasma levels in human visceral leishmaniasis: Implications in the pathogenesis |
| spellingShingle |
Balance of IL-10 and Interferon-γ plasma levels in human visceral leishmaniasis: Implications in the pathogenesis Barral-Netto, Manoel |
| title_short |
Balance of IL-10 and Interferon-γ plasma levels in human visceral leishmaniasis: Implications in the pathogenesis |
| title_full |
Balance of IL-10 and Interferon-γ plasma levels in human visceral leishmaniasis: Implications in the pathogenesis |
| title_fullStr |
Balance of IL-10 and Interferon-γ plasma levels in human visceral leishmaniasis: Implications in the pathogenesis |
| title_full_unstemmed |
Balance of IL-10 and Interferon-γ plasma levels in human visceral leishmaniasis: Implications in the pathogenesis |
| title_sort |
Balance of IL-10 and Interferon-γ plasma levels in human visceral leishmaniasis: Implications in the pathogenesis |
| author |
Barral-Netto, Manoel |
| author_facet |
Barral-Netto, Manoel Barral, Aldina Maria Prado Caldas, Arlene de Jesus Mendes Favali, Cecilia Beatriz Fiuza Aquino, Dorlene Maria Cardoso de Vinhas, Vera Silvia de Freitas Weyenbergh, Johan van Brodskyn, Claudia Ida Jackson Mauricio Lopes |
| author_role |
author |
| author2 |
Barral, Aldina Maria Prado Caldas, Arlene de Jesus Mendes Favali, Cecilia Beatriz Fiuza Aquino, Dorlene Maria Cardoso de Vinhas, Vera Silvia de Freitas Weyenbergh, Johan van Brodskyn, Claudia Ida Jackson Mauricio Lopes |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Barral-Netto, Manoel Barral, Aldina Maria Prado Caldas, Arlene de Jesus Mendes Favali, Cecilia Beatriz Fiuza Aquino, Dorlene Maria Cardoso de Vinhas, Vera Silvia de Freitas Weyenbergh, Johan van Brodskyn, Claudia Ida Jackson Mauricio Lopes Barral-Netto, Manoel Barral, Aldina Maria Prado Caldas, Arlene de Jesus Mendes Favali, Cecilia Beatriz Fiuza Aquino, Dorlene Maria Cardoso de Vinhas, Vera Silvia de Freitas Weyenbergh, Johan van Brodskyn, Claudia Ida Jackson Mauricio Lopes |
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p.1-9 |
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2005 |
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2005 |
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2013-11-01T19:26:48Z |
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2013-11-01T19:26:48Z |
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1471-2334 |
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v.5 n. 113 |
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1471-2334 v.5 n. 113 |
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