Influence of HTLV-1 on the clinical, microbiologic and immunologic presentation of tuberculosis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2012 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/15504 |
Resumo: | p. 1-8 |
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Bastos, Maria de Lourdes SantosSantos, Silvane Maria BragaSouza, Anselmo de SantanaFinkmoore, BrookeBispo, OhanaBarreto, TassoCardoso, IngridBispo, IanaBastos, FláviaPereira, DanieleRiley, LeeCarvalho Filho, Edgar Marcelino de2014-08-07T13:25:03Z2014-08-07T13:25:03Z20121471-2334http://repositorio.ufba.br/ri/handle/ri/15504v. 12p. 1-8Background HTLV-1 is associated with increased susceptibility to Mycobacterium tuberculosis infection and severity of tuberculosis. Although previous studies have shown that HTLV-1 infected individuals have a low frequency of positive tuberculin skin test (TST) and decreasing in lymphoproliferative responses compared to HTLV-1 uninfected persons, these studies were not performed in individuals with history of tuberculosis or evidence of M. tuberculosis infection. Therefore the reasons why HTLV-1 infection increases susceptibility to infection and severity of tuberculosis are not understood.The aim of this study was to evaluate how HTLV-1 may influence the clinical, bacteriologic and immunologic presentation of tuberculosis. Methods The study prospectively enrolled and followed 13 new cases of tuberculosis associated with HTLV-1 (cases) and 25 patients with tuberculosis without HTLV-1 infection (controls). Clinical findings, bacterial load in the sputum, x-rays, immunological response and death were compared in the two groups. Results There were no differences in the demographic, clinical and TST response between the two study groups. IFN-γ and TNF-α production was higher in unstimulated cultures of mononuclear cells of case than in control patients (p < 0.01). While there was no difference in IFN-γ production in PPD stimulated cultures, TNF-α levels were lower in cases than in controls (p = 0.01). There was no difference in the bacterial load among the groups but sputum smear microscopy results became negative faster in cases than in controls. Death only occurred in two co-infected patients. Conclusion While the increased susceptibility for tuberculosis infection in HTLV-1 infected subjects may be related to impairment in TNF-α production, the severity of tuberculosis in co-infected patients may be due to the enhancement of the Th1 inflammatory response, rather than in their decreased ability to control bacterial growth.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-07-15T17:09:25Z No. of bitstreams: 1 Silvane B. Santos.pdf: 518149 bytes, checksum: f97dce2081150bbd89da0e3d5d66beae (MD5)Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2014-08-07T13:25:03Z (GMT) No. of bitstreams: 1 Silvane B. Santos.pdf: 518149 bytes, checksum: f97dce2081150bbd89da0e3d5d66beae (MD5)Made available in DSpace on 2014-08-07T13:25:03Z (GMT). No. of bitstreams: 1 Silvane B. Santos.pdf: 518149 bytes, checksum: f97dce2081150bbd89da0e3d5d66beae (MD5) Previous issue date: 2012http://dx.doi.org/ 10.1186/1471-2334-12-199reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAHTLV-1TuberculosisMycobacterium tuberculosisInfluence of HTLV-1 on the clinical, microbiologic and immunologic presentation of tuberculosisBMC Infectious Diseasesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleBrasilinfo:eu-repo/semantics/openAccessengORIGINALSilvane B. Santos.pdfSilvane B. Santos.pdfapplication/pdf518149https://repositorio.ufba.br/bitstream/ri/15504/1/Silvane%20B.%20Santos.pdff97dce2081150bbd89da0e3d5d66beaeMD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/15504/2/license.txt0d4b811ef71182510d2015daa7c8a900MD52TEXTSilvane B. Santos.pdf.txtSilvane B. 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| dc.title.pt_BR.fl_str_mv |
Influence of HTLV-1 on the clinical, microbiologic and immunologic presentation of tuberculosis |
| dc.title.alternative.pt_BR.fl_str_mv |
BMC Infectious Diseases |
| title |
Influence of HTLV-1 on the clinical, microbiologic and immunologic presentation of tuberculosis |
| spellingShingle |
Influence of HTLV-1 on the clinical, microbiologic and immunologic presentation of tuberculosis Bastos, Maria de Lourdes Santos HTLV-1 Tuberculosis Mycobacterium tuberculosis |
| title_short |
Influence of HTLV-1 on the clinical, microbiologic and immunologic presentation of tuberculosis |
| title_full |
Influence of HTLV-1 on the clinical, microbiologic and immunologic presentation of tuberculosis |
| title_fullStr |
Influence of HTLV-1 on the clinical, microbiologic and immunologic presentation of tuberculosis |
| title_full_unstemmed |
Influence of HTLV-1 on the clinical, microbiologic and immunologic presentation of tuberculosis |
| title_sort |
Influence of HTLV-1 on the clinical, microbiologic and immunologic presentation of tuberculosis |
| author |
Bastos, Maria de Lourdes Santos |
| author_facet |
Bastos, Maria de Lourdes Santos Santos, Silvane Maria Braga Souza, Anselmo de Santana Finkmoore, Brooke Bispo, Ohana Barreto, Tasso Cardoso, Ingrid Bispo, Iana Bastos, Flávia Pereira, Daniele Riley, Lee Carvalho Filho, Edgar Marcelino de |
| author_role |
author |
| author2 |
Santos, Silvane Maria Braga Souza, Anselmo de Santana Finkmoore, Brooke Bispo, Ohana Barreto, Tasso Cardoso, Ingrid Bispo, Iana Bastos, Flávia Pereira, Daniele Riley, Lee Carvalho Filho, Edgar Marcelino de |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Bastos, Maria de Lourdes Santos Santos, Silvane Maria Braga Souza, Anselmo de Santana Finkmoore, Brooke Bispo, Ohana Barreto, Tasso Cardoso, Ingrid Bispo, Iana Bastos, Flávia Pereira, Daniele Riley, Lee Carvalho Filho, Edgar Marcelino de |
| dc.subject.por.fl_str_mv |
HTLV-1 Tuberculosis Mycobacterium tuberculosis |
| topic |
HTLV-1 Tuberculosis Mycobacterium tuberculosis |
| description |
p. 1-8 |
| publishDate |
2012 |
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2012 |
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2014-08-07T13:25:03Z |
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2014-08-07T13:25:03Z |
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1471-2334 |
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v. 12 |
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1471-2334 v. 12 |
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http://dx.doi.org/ 10.1186/1471-2334-12-199 |
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reponame:Repositório Institucional da UFBA instname:Universidade Federal da Bahia (UFBA) instacron:UFBA |
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