Leishmania amazonensis: Participation of regulatory T and B cells in the in vitro priming (PIV) of CBA/J spleen cells susceptible response

Detalhes bibliográficos
Autor(a) principal: Freitas, Luiz Antônio Rodrigues de
Data de Publicação: 2006
Outros Autores: Santana, Cláudia Dias de, Veras, Patrícia Sampaio Tavares, Welby-Borges, Marcus, Nihei, Jorge S., Cardillo, Fabíola
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/12490
Resumo: Texto completo: acesso restrito. p.201–205
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spelling Freitas, Luiz Antônio Rodrigues deSantana, Cláudia Dias deVeras, Patrícia Sampaio TavaresWelby-Borges, MarcusNihei, Jorge S.Cardillo, FabíolaFreitas, Luiz Antônio Rodrigues deSantana, Cláudia Dias deVeras, Patrícia Sampaio TavaresWelby-Borges, MarcusNihei, Jorge S.Cardillo, Fabíola2013-08-08T12:11:07Z20060014-4894http://www.repositorio.ufba.br/ri/handle/ri/12490v.113 n. 3Texto completo: acesso restrito. p.201–205CBA/J mice are resistant to Leishmania major and susceptible to Leishmania amazonensis. Early events determine infection outcome. Until now, PIV (in vitro priming) immune response to L. amazonensis has not been assessed. Herein, we have shown that compared to L. major, L. amazonensis induced higher parasite burden associated to similar IL-4, IFN-γ, and TNF-α mRNA expressions and IFN-γ and IL-10 levels. Although similar amounts of IL-10 were detected, the frequency of intracellular IL-10 positive B cells was enhanced in spleen cells stimulated with anti-CD3/anti-CD28, or anti-CD3/anti-CD28 and L. amazonensis, compared to L. major-stimulation. Interestingly, IL-10- producing B cells were reduced in response to anti-CD3/anti-CD28 stimulation combined with L. major compared to the other groups. L. amazonensis may favor T regulatory cell development, since 40% of all the CD4+CD25+ were CD25high cells. These data suggest that in PIV, susceptibility to L. amazonensis is not related to Th cell polarization, but to the presence and activity of regulatory T and B cells.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2013-08-08T12:11:07Z No. of bitstreams: 1 1-s2.0-S0014489406000099-main.pdf: 304340 bytes, checksum: 057e83846ed49fde782d133e5d48ac0a (MD5)Made available in DSpace on 2013-08-08T12:11:07Z (GMT). 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dc.title.pt_BR.fl_str_mv Leishmania amazonensis: Participation of regulatory T and B cells in the in vitro priming (PIV) of CBA/J spleen cells susceptible response
dc.title.alternative.pt_BR.fl_str_mv Experimental Parasitology
title Leishmania amazonensis: Participation of regulatory T and B cells in the in vitro priming (PIV) of CBA/J spleen cells susceptible response
spellingShingle Leishmania amazonensis: Participation of regulatory T and B cells in the in vitro priming (PIV) of CBA/J spleen cells susceptible response
Freitas, Luiz Antônio Rodrigues de
CBA/J mice
PIV
Leishmania amazonensis
Leishmania major
Regulatory T and B cells
title_short Leishmania amazonensis: Participation of regulatory T and B cells in the in vitro priming (PIV) of CBA/J spleen cells susceptible response
title_full Leishmania amazonensis: Participation of regulatory T and B cells in the in vitro priming (PIV) of CBA/J spleen cells susceptible response
title_fullStr Leishmania amazonensis: Participation of regulatory T and B cells in the in vitro priming (PIV) of CBA/J spleen cells susceptible response
title_full_unstemmed Leishmania amazonensis: Participation of regulatory T and B cells in the in vitro priming (PIV) of CBA/J spleen cells susceptible response
title_sort Leishmania amazonensis: Participation of regulatory T and B cells in the in vitro priming (PIV) of CBA/J spleen cells susceptible response
author Freitas, Luiz Antônio Rodrigues de
author_facet Freitas, Luiz Antônio Rodrigues de
Santana, Cláudia Dias de
Veras, Patrícia Sampaio Tavares
Welby-Borges, Marcus
Nihei, Jorge S.
Cardillo, Fabíola
author_role author
author2 Santana, Cláudia Dias de
Veras, Patrícia Sampaio Tavares
Welby-Borges, Marcus
Nihei, Jorge S.
Cardillo, Fabíola
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Freitas, Luiz Antônio Rodrigues de
Santana, Cláudia Dias de
Veras, Patrícia Sampaio Tavares
Welby-Borges, Marcus
Nihei, Jorge S.
Cardillo, Fabíola
Freitas, Luiz Antônio Rodrigues de
Santana, Cláudia Dias de
Veras, Patrícia Sampaio Tavares
Welby-Borges, Marcus
Nihei, Jorge S.
Cardillo, Fabíola
dc.subject.por.fl_str_mv CBA/J mice
PIV
Leishmania amazonensis
Leishmania major
Regulatory T and B cells
topic CBA/J mice
PIV
Leishmania amazonensis
Leishmania major
Regulatory T and B cells
description Texto completo: acesso restrito. p.201–205
publishDate 2006
dc.date.issued.fl_str_mv 2006
dc.date.accessioned.fl_str_mv 2013-08-08T12:11:07Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/12490
dc.identifier.issn.none.fl_str_mv 0014-4894
dc.identifier.number.pt_BR.fl_str_mv v.113 n. 3
identifier_str_mv 0014-4894
v.113 n. 3
url http://www.repositorio.ufba.br/ri/handle/ri/12490
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org.ez10.periodicos.capes.gov.br/10.1016/j.exppara.2006.01.008
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