A proteomic approach to identify proteins from Trichuris trichiura extract with immunomodulatory effects

Detalhes bibliográficos
Autor(a) principal: Santos, L. N.
Data de Publicação: 2013
Outros Autores: Gallo, M. B. C., Silva, E. S., Figueiredo, C. A. V., Cooper, P. J., Barreto, Mauricio Lima, Loureiro, Sebastião, Carvalho, Lain Carlos Pontes de, Alcântara-Neves, Neuza Maria
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/13832
Resumo: p. 188–193
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spelling Santos, L. N.Gallo, M. B. C.Silva, E. S.Figueiredo, C. A. V.Cooper, P. J.Barreto, Mauricio LimaLoureiro, SebastiãoCarvalho, Lain Carlos Pontes deAlcântara-Neves, Neuza MariaSantos, L. N.Gallo, M. B. C.Silva, E. S.Figueiredo, C. A. V.Cooper, P. J.Barreto, Mauricio LimaLoureiro, SebastiãoCarvalho, Lain Carlos Pontes deAlcântara-Neves, Neuza Maria2013-11-21T20:47:05Z20130141-9838http://repositorio.ufba.br/ri/handle/ri/13832v. 35, n. 5-6p. 188–193Infections with Trichuris trichiura and other trichurid nematodes have been reported to display protective effects against atopy, allergic and autoimmune diseases. The aims of the present study were to investigate the immunomodulatory properties of T. trichiura adult worm extract (TtE) and its fractions (TtEFs) on the production of cytokines by peripheral blood mononuclear cells and to identify their proteinaceous components. Fourteen TtEFs were obtained by ion exchange chromatography and tested for effects on cytokine production by peripheral blood mononuclear cells. The molecular constituents of the six most active fractions were evaluated using nano-LC/mass spectrometry. The homology between T. trichiura and the related nematode Trichinella spiralis was used to identify 12 proteins in TtEFs. Among those identified, fructose biphosphate aldolase, a homologue of macrophage migration inhibitory factor and heat-shock protein 70 may contribute to the immunomodulatory effects of TtEFs. The identification of such proteins could lead to the development of novel drugs for the therapy of allergic and other inflammatory diseases.Submitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2013-11-20T18:38:20Z No. of bitstreams: 1 222222.pdf: 1612595 bytes, checksum: 7b5e9a7dc11869fbd7947fe48ef2feae (MD5)Approved for entry into archive by Patricia Barroso (pbarroso@ufba.br) on 2013-11-21T20:47:03Z (GMT) No. of bitstreams: 1 222222.pdf: 1612595 bytes, checksum: 7b5e9a7dc11869fbd7947fe48ef2feae (MD5)Made available in DSpace on 2013-11-21T20:47:05Z (GMT). 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dc.title.pt_BR.fl_str_mv A proteomic approach to identify proteins from Trichuris trichiura extract with immunomodulatory effects
dc.title.alternative.pt_BR.fl_str_mv Parasite Immunology
title A proteomic approach to identify proteins from Trichuris trichiura extract with immunomodulatory effects
spellingShingle A proteomic approach to identify proteins from Trichuris trichiura extract with immunomodulatory effects
Santos, L. N.
Cytokine
Immunoregulation
Peripheral blood mononuclear cells
Proteomics
Trichuris spp
title_short A proteomic approach to identify proteins from Trichuris trichiura extract with immunomodulatory effects
title_full A proteomic approach to identify proteins from Trichuris trichiura extract with immunomodulatory effects
title_fullStr A proteomic approach to identify proteins from Trichuris trichiura extract with immunomodulatory effects
title_full_unstemmed A proteomic approach to identify proteins from Trichuris trichiura extract with immunomodulatory effects
title_sort A proteomic approach to identify proteins from Trichuris trichiura extract with immunomodulatory effects
author Santos, L. N.
author_facet Santos, L. N.
Gallo, M. B. C.
Silva, E. S.
Figueiredo, C. A. V.
Cooper, P. J.
Barreto, Mauricio Lima
Loureiro, Sebastião
Carvalho, Lain Carlos Pontes de
Alcântara-Neves, Neuza Maria
author_role author
author2 Gallo, M. B. C.
Silva, E. S.
Figueiredo, C. A. V.
Cooper, P. J.
Barreto, Mauricio Lima
Loureiro, Sebastião
Carvalho, Lain Carlos Pontes de
Alcântara-Neves, Neuza Maria
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Santos, L. N.
Gallo, M. B. C.
Silva, E. S.
Figueiredo, C. A. V.
Cooper, P. J.
Barreto, Mauricio Lima
Loureiro, Sebastião
Carvalho, Lain Carlos Pontes de
Alcântara-Neves, Neuza Maria
Santos, L. N.
Gallo, M. B. C.
Silva, E. S.
Figueiredo, C. A. V.
Cooper, P. J.
Barreto, Mauricio Lima
Loureiro, Sebastião
Carvalho, Lain Carlos Pontes de
Alcântara-Neves, Neuza Maria
dc.subject.por.fl_str_mv Cytokine
Immunoregulation
Peripheral blood mononuclear cells
Proteomics
Trichuris spp
topic Cytokine
Immunoregulation
Peripheral blood mononuclear cells
Proteomics
Trichuris spp
description p. 188–193
publishDate 2013
dc.date.accessioned.fl_str_mv 2013-11-21T20:47:05Z
dc.date.issued.fl_str_mv 2013
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/13832
dc.identifier.issn.none.fl_str_mv 0141-9838
dc.identifier.number.pt_BR.fl_str_mv v. 35, n. 5-6
identifier_str_mv 0141-9838
v. 35, n. 5-6
url http://repositorio.ufba.br/ri/handle/ri/13832
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Parasite Immunology
publisher.none.fl_str_mv Parasite Immunology
dc.source.pt_BR.fl_str_mv http://onlinelibrary.wiley.com/doi/10.1111/pim.12025/pdf
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
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instacron_str UFBA
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reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
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