Evaluating the efficacy of allopurinol for the treatment of cutaneous leishmaniasis

Detalhes bibliográficos
Autor(a) principal: D'Oliveira Junior, Argemiro
Data de Publicação: 1997
Outros Autores: Machado, Paulo Roberto Lima, Carvalho Filho, Edgar Marcelino de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/8290
Resumo: Texto completo: acesso restrito. p.938–940
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spelling D'Oliveira Junior, ArgemiroMachado, Paulo Roberto LimaCarvalho Filho, Edgar Marcelino deD'Oliveira Junior, ArgemiroMachado, Paulo Roberto LimaCarvalho Filho, Edgar Marcelino de2013-01-31T13:08:45Z19970011-9059http://www.repositorio.ufba.br/ri/handle/ri/8290v. 36, n. 12Texto completo: acesso restrito. p.938–940This study was performed in Corte de Pedra, an area of L. braziliensis braziliensis transmission located 240 km southeast of Salvador, the capital of the state of Bahia in Brazil. This open controlled trial included 34 patients, aged 12 to 45 years, with leishmania-positive skin test and a maximum of three ulcerated lesions (with a minimum lesion diameter of 10 mm and a maximum diameter of 50 mm) who had received no previous treatment. Exclusion criteria included chronic disease, use of other drugs, history of allergy to allopurinol, pregnancy, breast feeding, or forms of leishmaniasis other than cutaneous. Informed consent was obtained from all subjects after the nature of the procedures had been fully explained to them. Randomly selected patients received 20 mg/kg of allopurinol orally, three times a day, or 10 mg/kg of intravenous antimoniate of meglumine, once a day. Both patient groups used the drugs for a period of 20 days. A clinical history was collected and a physical examination was performed on all patients before initiating the treatment. Lesions were photographed and biopsied, and the tissue was used for histopathologic study and inoculation in hamsters and appropriate culture media. Patients were re-examined on days 10 and 20 and at monthly intervals for 1 year following the beginning of treatment. Blood samples for serologic and biochemical analysis (measurements of serum uric acid, urea, crsatinine, and transaminases) were collected at days 0, 10, and 22 following the beginning of treatment. The definition of therapeutic failure included incompletion of the treatment protocol, use of a treatment different from the protocol, lesions not healed 3 months after the beginning of treatment, or relapse or development of new cutaneous or mucosal lesions caused by leishmaniasis within 1 year of treatment. The exact Fischer test was used to compare the treatment results between the two patient groups. Student's t-test was used to compare the age of the patients and the duration of the illness. The Mann-Whitney test was used to compare the diameter of the lesions at day 0 and 3 months after treatment completion in the two groups, and the Kruskal-Wallis test was used to compare the number of lesions per patient and their localization.Submitted by Suelen Reis (suelen_suzane@hotmail.com) on 2013-01-31T12:25:23Z No. of bitstreams: 1 D'Oliveira.pdf: 2691920 bytes, checksum: 5f9829b810a924221f28b28a7c269e52 (MD5)Approved for entry into archive by Fatima Cleômenis Botelho Maria (botelho@ufba.br) on 2013-01-31T13:08:45Z (GMT) No. of bitstreams: 1 D'Oliveira.pdf: 2691920 bytes, checksum: 5f9829b810a924221f28b28a7c269e52 (MD5)Made available in DSpace on 2013-01-31T13:08:45Z (GMT). No. of bitstreams: 1 D'Oliveira.pdf: 2691920 bytes, checksum: 5f9829b810a924221f28b28a7c269e52 (MD5) Previous issue date: 1997http://dx.doi.org/10.1046/j.1365-4362.1997.00308.xreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAEvaluating the efficacy of allopurinol for the treatment of cutaneous leishmaniasisInternational Journal of Dermatologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINALD'Oliveira.pdfD'Oliveira.pdfapplication/pdf2691920https://repositorio.ufba.br/bitstream/ri/8290/1/D%27Oliveira.pdf5f9829b810a924221f28b28a7c269e52MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/8290/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTD'Oliveira.pdf.txtD'Oliveira.pdf.txtExtracted texttext/plain12320https://repositorio.ufba.br/bitstream/ri/8290/3/D%27Oliveira.pdf.txt79dcbb797cd03b2863d80c5ba3157227MD53ri/82902022-08-08 13:17:50.301oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-08-08T16:17:50Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Evaluating the efficacy of allopurinol for the treatment of cutaneous leishmaniasis
dc.title.alternative.pt_BR.fl_str_mv International Journal of Dermatology
title Evaluating the efficacy of allopurinol for the treatment of cutaneous leishmaniasis
spellingShingle Evaluating the efficacy of allopurinol for the treatment of cutaneous leishmaniasis
D'Oliveira Junior, Argemiro
title_short Evaluating the efficacy of allopurinol for the treatment of cutaneous leishmaniasis
title_full Evaluating the efficacy of allopurinol for the treatment of cutaneous leishmaniasis
title_fullStr Evaluating the efficacy of allopurinol for the treatment of cutaneous leishmaniasis
title_full_unstemmed Evaluating the efficacy of allopurinol for the treatment of cutaneous leishmaniasis
title_sort Evaluating the efficacy of allopurinol for the treatment of cutaneous leishmaniasis
author D'Oliveira Junior, Argemiro
author_facet D'Oliveira Junior, Argemiro
Machado, Paulo Roberto Lima
Carvalho Filho, Edgar Marcelino de
author_role author
author2 Machado, Paulo Roberto Lima
Carvalho Filho, Edgar Marcelino de
author2_role author
author
dc.contributor.author.fl_str_mv D'Oliveira Junior, Argemiro
Machado, Paulo Roberto Lima
Carvalho Filho, Edgar Marcelino de
D'Oliveira Junior, Argemiro
Machado, Paulo Roberto Lima
Carvalho Filho, Edgar Marcelino de
description Texto completo: acesso restrito. p.938–940
publishDate 1997
dc.date.issued.fl_str_mv 1997
dc.date.accessioned.fl_str_mv 2013-01-31T13:08:45Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/8290
dc.identifier.issn.none.fl_str_mv 0011-9059
dc.identifier.number.pt_BR.fl_str_mv v. 36, n. 12
identifier_str_mv 0011-9059
v. 36, n. 12
url http://www.repositorio.ufba.br/ri/handle/ri/8290
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1046/j.1365-4362.1997.00308.x
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collection Repositório Institucional da UFBA
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