Types of marriages, population structure and genetic disease
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFBA |
Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/13597 |
Resumo: | p. 461–470 |
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Machado, Taisa Manuela BonfimBomfim, Thaís FerreiraSouza, L. V.Soares, N.Santos, F. L.Acosta, Angelina XavierAbe Sandes, Kiyoko2013-11-08T18:29:17Z2013-11-08T18:29:17Z20130021-9320http://repositorio.ufba.br/ri/handle/ri/13597p. 461–470A high occurrence rate of consanguineous marriages may favour the onset and increased frequency of autosomal recessive diseases in a population. The population of Monte Santo, Bahia, Brazil, has a high frequency of rare genetic diseases such as mucopolysaccharidosis type VI, whose observed frequency in this population is 1:5000, while the incidence of this disease recorded in other regions of the world varies from 1:43,261 in Turkey to 1:1,505,160 in Switzerland. To verify the influence of consanguineous marriage on the increased frequency of observed genetic diseases in this population, the population structure and frequency of different types of marriage during different time periods were evaluated. A total of 9765 marriages were found in an analysis of parish marriage records from the city. Over three periods, 1860–1895, 1950–1961 and 1975–2010, the inbreeding rates were 37.1%, 13.2% and 4.2% respectively. Although there was a high rate of inbreeding, endogamic marriages were the dominant marriage type in all three periods. In the most recent period, there was an increase in the number of exogamous marriages and those among immigrants, but most of these occurred among individuals from cities that neighbour Monte Santo. The low rate of migration and high frequency of endogamic and consanguineous marriages show that growth of this population is predominantly internal and could explain the occurrence, and increase in frequency, of recessive genetic diseases in the city.Submitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2013-10-29T18:30:59Z No. of bitstreams: 1 22222.pdf: 327991 bytes, checksum: 2034040204790d41f69575c6eeee012f (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2013-11-08T18:29:17Z (GMT) No. of bitstreams: 1 22222.pdf: 327991 bytes, checksum: 2034040204790d41f69575c6eeee012f (MD5)Made available in DSpace on 2013-11-08T18:29:17Z (GMT). No. of bitstreams: 1 22222.pdf: 327991 bytes, checksum: 2034040204790d41f69575c6eeee012f (MD5) Previous issue date: 2013SalvadorJournal of Biosocial ScienceBrasilhttp://journals.cambridge.org/abstract_S0021932012000673reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBATypes of marriages, population structure and genetic diseaseJournal of Biosocial Scienceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessengORIGINAL22222.pdf22222.pdfapplication/pdf327991https://repositorio.ufba.br/bitstream/ri/13597/1/22222.pdf2034040204790d41f69575c6eeee012fMD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/13597/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXT22222.pdf.txt22222.pdf.txtExtracted texttext/plain29989https://repositorio.ufba.br/bitstream/ri/13597/3/22222.pdf.txta295028b3d25e30f196942db896f39c4MD53ri/135972022-03-09 20:29:14.429oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-03-09T23:29:14Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
dc.title.pt_BR.fl_str_mv |
Types of marriages, population structure and genetic disease |
dc.title.alternative.pt_BR.fl_str_mv |
Journal of Biosocial Science |
title |
Types of marriages, population structure and genetic disease |
spellingShingle |
Types of marriages, population structure and genetic disease Machado, Taisa Manuela Bonfim |
title_short |
Types of marriages, population structure and genetic disease |
title_full |
Types of marriages, population structure and genetic disease |
title_fullStr |
Types of marriages, population structure and genetic disease |
title_full_unstemmed |
Types of marriages, population structure and genetic disease |
title_sort |
Types of marriages, population structure and genetic disease |
author |
Machado, Taisa Manuela Bonfim |
author_facet |
Machado, Taisa Manuela Bonfim Bomfim, Thaís Ferreira Souza, L. V. Soares, N. Santos, F. L. Acosta, Angelina Xavier Abe Sandes, Kiyoko |
author_role |
author |
author2 |
Bomfim, Thaís Ferreira Souza, L. V. Soares, N. Santos, F. L. Acosta, Angelina Xavier Abe Sandes, Kiyoko |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Machado, Taisa Manuela Bonfim Bomfim, Thaís Ferreira Souza, L. V. Soares, N. Santos, F. L. Acosta, Angelina Xavier Abe Sandes, Kiyoko |
description |
p. 461–470 |
publishDate |
2013 |
dc.date.accessioned.fl_str_mv |
2013-11-08T18:29:17Z |
dc.date.available.fl_str_mv |
2013-11-08T18:29:17Z |
dc.date.issued.fl_str_mv |
2013 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
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publishedVersion |
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http://repositorio.ufba.br/ri/handle/ri/13597 |
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0021-9320 |
identifier_str_mv |
0021-9320 |
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http://repositorio.ufba.br/ri/handle/ri/13597 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Journal of Biosocial Science |
dc.publisher.country.fl_str_mv |
Brasil |
publisher.none.fl_str_mv |
Journal of Biosocial Science |
dc.source.pt_BR.fl_str_mv |
http://journals.cambridge.org/abstract_S0021932012000673 |
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reponame:Repositório Institucional da UFBA instname:Universidade Federal da Bahia (UFBA) instacron:UFBA |
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Universidade Federal da Bahia (UFBA) |
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UFBA |
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UFBA |
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Repositório Institucional da UFBA |
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Repositório Institucional da UFBA |
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