Hepatitis B Infection Is Associated with Asymptomatic Malaria in the Brazilian Amazon
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2011 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/5344 |
Resumo: | Acesso restrito: Texto completo. p. 1-9. |
| id |
UFBA-2_8e71008115cf050deefd9b3fba1c558a |
|---|---|
| oai_identifier_str |
oai:repositorio.ufba.br:ri/5344 |
| network_acronym_str |
UFBA-2 |
| network_name_str |
Repositório Institucional da UFBA |
| repository_id_str |
1932 |
| spelling |
Andrade, Bruno BezerrilSantos, Cristiane J. N.Camargo, Luís Marcelo AranhaSouza Neto, Sebastião MartinsReis Filho, AntonioClarêncio, JorgeMendonça, Vitor Rosa Ramos deLuz, Nívea FariasCamargo, Erney PlessmannBarral, Aldina Maria PradoSilva, Antônio A. M.Barral-Netto, ManoelAndrade, Bruno BezerrilSantos, Cristiane J. N.Camargo, Luís Marcelo AranhaSouza Neto, Sebastião MartinsReis Filho, AntonioClarêncio, JorgeMendonça, Vitor Rosa Ramos deLuz, Nívea FariasCamargo, Erney PlessmannBarral, Aldina Maria PradoSilva, Antônio A. M.Barral-Netto, Manoel2012-02-08T18:43:30Z20111932-6203http://www.repositorio.ufba.br/ri/handle/ri/5344v. 6, n. 5.Acesso restrito: Texto completo. p. 1-9.Background: Areas that are endemic for malaria are also highly endemic for hepatitis B virus (HBV) infection. Nevertheless, it is unknown whether HBV infection modifies the clinical presentation of malaria. This study aimed to address this question. Methodology and Findings: An observational study of 636 individuals was performed in Rondoˆ nia, western Amazon, Brazil between 2006 and 2007. Active and passive case detections identified Plasmodium infection by field microscopy and nested Polymerase Chain Reaction (PCR). HBV infections were identified by serology and confirmed by real-time PCR. Epidemiological information and plasma cytokine profiles were studied. The data were analyzed using adjusted multinomial logistic regression. Plasmodium-infected individuals with active HBV infection were more likely to be asymptomatic (OR: 120.13, P,0.0001), present with lower levels of parasitemia and demonstrate a decreased inflammatory cytokine profile. Nevertheless, co-infected individuals presented higher HBV viremia. Plasmodium parasitemia inversely correlated with plasma HBV DNA levels (r =20.6; P = 0.0003). Conclusion: HBV infection diminishes the intensity of malaria infection in individuals from this endemic area. This effect seems related to cytokine balance and control of inflammatory responses. These findings add important insights to the understanding of the factors affecting the clinical outcomes of malaria in endemic regions.Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2012-02-08T18:43:30Z No. of bitstreams: 1 journal.pone.0019841.pdf: 623458 bytes, checksum: 238db9e3472a568aa80adabda35bdbc4 (MD5)Made available in DSpace on 2012-02-08T18:43:30Z (GMT). No. of bitstreams: 1 journal.pone.0019841.pdf: 623458 bytes, checksum: 238db9e3472a568aa80adabda35bdbc4 (MD5) Previous issue date: 2011http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0019841reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAHepatitis B Infection Is Associated with Asymptomatic Malaria in the Brazilian AmazonPlos oneinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINALjournal.pone.0019841.pdfjournal.pone.0019841.pdfapplication/pdf623458https://repositorio.ufba.br/bitstream/ri/5344/1/journal.pone.0019841.pdf238db9e3472a568aa80adabda35bdbc4MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/5344/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTjournal.pone.0019841.pdf.txtjournal.pone.0019841.pdf.txtExtracted texttext/plain39664https://repositorio.ufba.br/bitstream/ri/5344/3/journal.pone.0019841.pdf.txt8a02d490012a88f99b5bd7e11095b1faMD53ri/53442022-07-05 14:03:09.051oai:repositorio.ufba.br:ri/5344VGVybW8gZGUgTGljZW7vv71hLCBu77+9byBleGNsdXNpdm8sIHBhcmEgbyBkZXDvv71zaXRvIG5vIHJlcG9zaXTvv71yaW8gSW5zdGl0dWNpb25hbCBkYSBVRkJBCgogICAgUGVsbyBwcm9jZXNzbyBkZSBzdWJtaXNz77+9byBkZSBkb2N1bWVudG9zLCBvIGF1dG9yIG91IHNldQpyZXByZXNlbnRhbnRlIGxlZ2FsLCBhbyBhY2VpdGFyIGVzc2UgdGVybW8gZGUgbGljZW7vv71hLCBjb25jZWRlIGFvClJlcG9zaXTvv71yaW8gSW5zdGl0dWNpb25hbCBkYSBVbml2ZXJzaWRhZGUgRmVkZXJhbCBkYSBCYWhpYSBvIGRpcmVpdG8KZGUgbWFudGVyIHVtYSBj77+9cGlhIGVtIHNldSByZXBvc2l077+9cmlvIGNvbSBhIGZpbmFsaWRhZGUsIHByaW1laXJhLCAKZGUgcHJlc2VydmHvv73vv71vLiBFc3NlcyB0ZXJtb3MsIG7vv71vIGV4Y2x1c2l2b3MsIG1hbnTvv71tIG9zIGRpcmVpdG9zIGRlIAphdXRvci9jb3B5cmlnaHQsIG1hcyBlbnRlbmRlIG8gZG9jdW1lbnRvIGNvbW8gcGFydGUgZG8gYWNlcnZvIGludGVsZWN0dWFsIGRlc3NhIFVuaXZlcnNpZGFkZS4gCgogICAgUGFyYSBvcyBkb2N1bWVudG9zIHB1YmxpY2Fkb3MgY29tIHJlcGFzc2UgZGUgZGlyZWl0b3MgZGUgZGlzdHJpYnVp77+977+9bywgZXNzZSB0ZXJtbyBkZSBsaWNlbu+/vWEgZW50ZW5kZSBxdWU6IAoKICAgIE1hbnRlbmRvIG9zICBkaXJlaXRvcyBhdXRvcmFpcywgcmVwYXNzYWRvcyBhIHRlcmNlaXJvcywgZW0gY2FzbyAKZGUgcHVibGljYe+/ve+/vWVzLCBvIHJlcG9zaXTvv71yaW8gcG9kZSByZXN0cmluZ2lyIG8gYWNlc3NvIGFvIHRleHRvIAppbnRlZ3JhbCwgbWFzIGxpYmVyYSBhcyBpbmZvcm1h77+977+9ZXMgc29icmUgbyBkb2N1bWVudG8gKE1ldGFkYWRvcyBkZXNjcml0aXZvcykuCgogRGVzdGEgZm9ybWEsIGF0ZW5kZW5kbyBhb3MgYW5zZWlvcyBkZXNzYSB1bml2ZXJzaWRhZGUgCmVtIG1hbnRlciBzdWEgcHJvZHXvv73vv71vIGNpZW5077+9ZmljYSBjb20gYXMgcmVzdHJp77+977+9ZXMgaW1wb3N0YXMgcGVsb3MgCmVkaXRvcmVzIGRlIHBlcmnvv71kaWNvcy4gCgogICAgUGFyYSBhcyBwdWJsaWNh77+977+9ZXMgZW0gaW5pY2lhdGl2YXMgcXVlIHNlZ3VlbSBhIHBvbO+/vXRpY2EgZGUgCkFjZXNzbyBBYmVydG8sIG9zIGRlcO+/vXNpdG9zIGNvbXB1bHPvv71yaW9zIG5lc3NlIHJlcG9zaXTvv71yaW8gbWFudO+/vW0gCm9zIGRpcmVpdG9zIGF1dG9yYWlzLCBtYXMgbWFudO+/vW0gbyBhY2Vzc28gaXJyZXN0cml0byBhbyBtZXRhZGFkb3MgCmUgdGV4dG8gY29tcGxldG8uIEFzc2ltLCBhIGFjZWl0Ye+/ve+/vW8gZGVzc2UgdGVybW8gbu+/vW8gbmVjZXNzaXRhIGRlIApjb25zZW50aW1lbnRvIHBvciBwYXJ0ZSBkZSBhdXRvcmVzL2RldGVudG9yZXMgZG9zIGRpcmVpdG9zLCBwb3IgCmVzdGFyZW0gZW0gaW5pY2lhdGl2YXMgZGUgYWNlc3NvIGFiZXJ0by4KCiAgICBFbSBhbWJvcyBvIGNhc28sIGVzc2UgdGVybW8gZGUgbGljZW7vv71hLCBwb2RlIHNlciBhY2VpdG8gcGVsbyAKYXV0b3IsIGRldGVudG9yZXMgZGUgZGlyZWl0b3MgZS9vdSB0ZXJjZWlyb3MgYW1wYXJhZG9zIHBlbGEgCnVuaXZlcnNpZGFkZS4gRGV2aWRvIGFvcyBkaWZlcmVudGVzIHByb2Nlc3NvcyBwZWxvIHF1YWwgYSBzdWJtaXNz77+9byAKcG9kZSBvY29ycmVyLCBvIHJlcG9zaXTvv71yaW8gcGVybWl0ZSBhIGFjZWl0Ye+/ve+/vW8gZGEgbGljZW7vv71hIHBvciAKdGVyY2Vpcm9zLCBzb21lbnRlIG5vcyBjYXNvcyBkZSBkb2N1bWVudG9zIHByb2R1emlkb3MgcG9yIGludGVncmFudGVzIApkYSBVRkJBIGUgc3VibWV0aWRvcyBwb3IgcGVzc29hcyBhbXBhcmFkYXMgcG9yIGVzdGEgaW5zdGl0dWnvv73vv71vLgo=Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:09Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Hepatitis B Infection Is Associated with Asymptomatic Malaria in the Brazilian Amazon |
| dc.title.alternative.pt_BR.fl_str_mv |
Plos one |
| title |
Hepatitis B Infection Is Associated with Asymptomatic Malaria in the Brazilian Amazon |
| spellingShingle |
Hepatitis B Infection Is Associated with Asymptomatic Malaria in the Brazilian Amazon Andrade, Bruno Bezerril |
| title_short |
Hepatitis B Infection Is Associated with Asymptomatic Malaria in the Brazilian Amazon |
| title_full |
Hepatitis B Infection Is Associated with Asymptomatic Malaria in the Brazilian Amazon |
| title_fullStr |
Hepatitis B Infection Is Associated with Asymptomatic Malaria in the Brazilian Amazon |
| title_full_unstemmed |
Hepatitis B Infection Is Associated with Asymptomatic Malaria in the Brazilian Amazon |
| title_sort |
Hepatitis B Infection Is Associated with Asymptomatic Malaria in the Brazilian Amazon |
| author |
Andrade, Bruno Bezerril |
| author_facet |
Andrade, Bruno Bezerril Santos, Cristiane J. N. Camargo, Luís Marcelo Aranha Souza Neto, Sebastião Martins Reis Filho, Antonio Clarêncio, Jorge Mendonça, Vitor Rosa Ramos de Luz, Nívea Farias Camargo, Erney Plessmann Barral, Aldina Maria Prado Silva, Antônio A. M. Barral-Netto, Manoel |
| author_role |
author |
| author2 |
Santos, Cristiane J. N. Camargo, Luís Marcelo Aranha Souza Neto, Sebastião Martins Reis Filho, Antonio Clarêncio, Jorge Mendonça, Vitor Rosa Ramos de Luz, Nívea Farias Camargo, Erney Plessmann Barral, Aldina Maria Prado Silva, Antônio A. M. Barral-Netto, Manoel |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Andrade, Bruno Bezerril Santos, Cristiane J. N. Camargo, Luís Marcelo Aranha Souza Neto, Sebastião Martins Reis Filho, Antonio Clarêncio, Jorge Mendonça, Vitor Rosa Ramos de Luz, Nívea Farias Camargo, Erney Plessmann Barral, Aldina Maria Prado Silva, Antônio A. M. Barral-Netto, Manoel Andrade, Bruno Bezerril Santos, Cristiane J. N. Camargo, Luís Marcelo Aranha Souza Neto, Sebastião Martins Reis Filho, Antonio Clarêncio, Jorge Mendonça, Vitor Rosa Ramos de Luz, Nívea Farias Camargo, Erney Plessmann Barral, Aldina Maria Prado Silva, Antônio A. M. Barral-Netto, Manoel |
| description |
Acesso restrito: Texto completo. p. 1-9. |
| publishDate |
2011 |
| dc.date.issued.fl_str_mv |
2011 |
| dc.date.accessioned.fl_str_mv |
2012-02-08T18:43:30Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://www.repositorio.ufba.br/ri/handle/ri/5344 |
| dc.identifier.issn.none.fl_str_mv |
1932-6203 |
| dc.identifier.number.pt_BR.fl_str_mv |
v. 6, n. 5. |
| identifier_str_mv |
1932-6203 v. 6, n. 5. |
| url |
http://www.repositorio.ufba.br/ri/handle/ri/5344 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.source.pt_BR.fl_str_mv |
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0019841 |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFBA instname:Universidade Federal da Bahia (UFBA) instacron:UFBA |
| instname_str |
Universidade Federal da Bahia (UFBA) |
| instacron_str |
UFBA |
| institution |
UFBA |
| reponame_str |
Repositório Institucional da UFBA |
| collection |
Repositório Institucional da UFBA |
| bitstream.url.fl_str_mv |
https://repositorio.ufba.br/bitstream/ri/5344/1/journal.pone.0019841.pdf https://repositorio.ufba.br/bitstream/ri/5344/2/license.txt https://repositorio.ufba.br/bitstream/ri/5344/3/journal.pone.0019841.pdf.txt |
| bitstream.checksum.fl_str_mv |
238db9e3472a568aa80adabda35bdbc4 1b89a9a0548218172d7c829f87a0eab9 8a02d490012a88f99b5bd7e11095b1fa |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA) |
| repository.mail.fl_str_mv |
|
| _version_ |
1808459394233401344 |