Characterization of regulatory T cell (Treg) function in patients infected with Leishmania braziliensis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2013 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/15034 |
Resumo: | Texto completo: acesso restrito. p. 1491–1500 |
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Costa, Diego LuisGuimarães, Luiz H.Cardoso, Thiago M.Queiroz, AdrianoLago, Ednaldo LimaRoselino, Ana M.Bacellar, Maria Olívia Amado RamosCarvalho Filho, Edgar Marcelino deSilva, João S.Costa, Diego LuisGuimarães, Luiz H.Cardoso, Thiago M.Queiroz, AdrianoLago, Ednaldo LimaRoselino, Ana M.Bacellar, Maria Olívia Amado RamosCarvalho Filho, Edgar Marcelino deSilva, João S.2014-06-02T11:33:19Z20130198-8859http://repositorio.ufba.br/ri/handle/ri/15034v. 74, n. 12Texto completo: acesso restrito. p. 1491–1500Th1 immune responses are crucial for eliminating Leishmania parasites. However, despite strong Th1 responses, cutaneous leishmaniasis (CL) patients infected with Leishmania braziliensis develop the disease, while milder Th1 responses are found in sub-clinical (SC) infections. Therefore, CL patients may experience impaired regulatory T cell (Treg) function, causing excessive Th1 responses and tissue damage. To address this hypothesis, we characterized the function of circulating Tregs in L. braziliensis infected CL patients and compared them to Tregs from uninfected controls (UC) and SC subjects. The frequency of circulating Tregs was similar in CL patients, UC and SC subjects. Moreover, CL patients Tregs suppressed lymphocyte proliferation and PBMC pro-inflammatory cytokine production more efficiently than UC Tregs, and also produced higher levels of IL-10 than UC and SC Tregs. Furthermore, PBMC and mononuclear cells from lesions of CL patients responded normally to Treg-induced suppression. Therefore, the lesion development in CL patients infected with L. braziliensis is not associated with impairment in Treg function or failure of cells to respond to immunomodulation. Rather, the increased Treg activation in CL patients may impair parasite elimination, resulting in establishment of chronic infection. Thus, immunological strategies that interfere with this response may improve leishmaniasis treatment.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-04-29T17:05:14Z No. of bitstreams: 1 1-s2.0-S0198885913004941-main.pdf: 1938576 bytes, checksum: d3439607edf50622cba711a087c1370a (MD5)Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2014-06-02T11:33:19Z (GMT) No. of bitstreams: 1 1-s2.0-S0198885913004941-main.pdf: 1938576 bytes, checksum: d3439607edf50622cba711a087c1370a (MD5)Made available in DSpace on 2014-06-02T11:33:19Z (GMT). No. of bitstreams: 1 1-s2.0-S0198885913004941-main.pdf: 1938576 bytes, checksum: d3439607edf50622cba711a087c1370a (MD5) Previous issue date: 2013http://dx.doi.org/10.1016/j.humimm.2013.08.269reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAInterleukin-10Leishmania braziliensisAntigensCell SeparationCD4-Positive T-LymphocytesReceptors, CytokineInterleukin-2Characterization of regulatory T cell (Treg) function in patients infected with Leishmania braziliensisHuman Immunologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINAL1-s2.0-S0198885913004941-main.pdf1-s2.0-S0198885913004941-main.pdfapplication/pdf1938576https://repositorio.ufba.br/bitstream/ri/15034/1/1-s2.0-S0198885913004941-main.pdfd3439607edf50622cba711a087c1370aMD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/15034/2/license.txt0d4b811ef71182510d2015daa7c8a900MD52TEXT1-s2.0-S0198885913004941-main.pdf.txt1-s2.0-S0198885913004941-main.pdf.txtExtracted texttext/plain50461https://repositorio.ufba.br/bitstream/ri/15034/3/1-s2.0-S0198885913004941-main.pdf.txt9cbccfd42026eb8040dd7d1ab5ef7a8dMD53ri/150342022-08-08 13:17:47.958oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-08-08T16:17:47Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Characterization of regulatory T cell (Treg) function in patients infected with Leishmania braziliensis |
| dc.title.alternative.pt_BR.fl_str_mv |
Human Immunology |
| title |
Characterization of regulatory T cell (Treg) function in patients infected with Leishmania braziliensis |
| spellingShingle |
Characterization of regulatory T cell (Treg) function in patients infected with Leishmania braziliensis Costa, Diego Luis Interleukin-10 Leishmania braziliensis Antigens Cell Separation CD4-Positive T-Lymphocytes Receptors, Cytokine Interleukin-2 |
| title_short |
Characterization of regulatory T cell (Treg) function in patients infected with Leishmania braziliensis |
| title_full |
Characterization of regulatory T cell (Treg) function in patients infected with Leishmania braziliensis |
| title_fullStr |
Characterization of regulatory T cell (Treg) function in patients infected with Leishmania braziliensis |
| title_full_unstemmed |
Characterization of regulatory T cell (Treg) function in patients infected with Leishmania braziliensis |
| title_sort |
Characterization of regulatory T cell (Treg) function in patients infected with Leishmania braziliensis |
| author |
Costa, Diego Luis |
| author_facet |
Costa, Diego Luis Guimarães, Luiz H. Cardoso, Thiago M. Queiroz, Adriano Lago, Ednaldo Lima Roselino, Ana M. Bacellar, Maria Olívia Amado Ramos Carvalho Filho, Edgar Marcelino de Silva, João S. |
| author_role |
author |
| author2 |
Guimarães, Luiz H. Cardoso, Thiago M. Queiroz, Adriano Lago, Ednaldo Lima Roselino, Ana M. Bacellar, Maria Olívia Amado Ramos Carvalho Filho, Edgar Marcelino de Silva, João S. |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Costa, Diego Luis Guimarães, Luiz H. Cardoso, Thiago M. Queiroz, Adriano Lago, Ednaldo Lima Roselino, Ana M. Bacellar, Maria Olívia Amado Ramos Carvalho Filho, Edgar Marcelino de Silva, João S. Costa, Diego Luis Guimarães, Luiz H. Cardoso, Thiago M. Queiroz, Adriano Lago, Ednaldo Lima Roselino, Ana M. Bacellar, Maria Olívia Amado Ramos Carvalho Filho, Edgar Marcelino de Silva, João S. |
| dc.subject.por.fl_str_mv |
Interleukin-10 Leishmania braziliensis Antigens Cell Separation CD4-Positive T-Lymphocytes Receptors, Cytokine Interleukin-2 |
| topic |
Interleukin-10 Leishmania braziliensis Antigens Cell Separation CD4-Positive T-Lymphocytes Receptors, Cytokine Interleukin-2 |
| description |
Texto completo: acesso restrito. p. 1491–1500 |
| publishDate |
2013 |
| dc.date.issued.fl_str_mv |
2013 |
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2014-06-02T11:33:19Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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http://repositorio.ufba.br/ri/handle/ri/15034 |
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0198-8859 |
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v. 74, n. 12 |
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0198-8859 v. 74, n. 12 |
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http://repositorio.ufba.br/ri/handle/ri/15034 |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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http://dx.doi.org/10.1016/j.humimm.2013.08.269 |
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reponame:Repositório Institucional da UFBA instname:Universidade Federal da Bahia (UFBA) instacron:UFBA |
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