Effect of central acute administration of cadmium on drinking behavior
Autor(a) principal: | |
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Data de Publicação: | 1996 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFBA |
Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/8450 |
Resumo: | Texto completo: acesso restrito. p.687–693 |
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Silva, E. de Castro EFerreira, H.Cunha, M.Bulcão, C.Sarmento, ClarissaOliveira, I. deFregoneze, J. B.Silva, E. de Castro EFerreira, H.Cunha, M.Bulcão, C.Sarmento, ClarissaOliveira, I. deFregoneze, J. B.2013-02-15T16:03:14Z19960091-3057http://www.repositorio.ufba.br/ri/handle/ri/8450v3 53, n. 3Texto completo: acesso restrito. p.687–693The effect of acute third ventricle cadmium administration on the drinking behavior of adult male rats under different situations was studied. Injections of cadmium chloride (0.07, 0.7, and 7.0 ng/rat) significantly attenuated water intake in dehydrated rats. Drinking behavior induced by acute intracerebroventricular injections of carbachol (2 μg/rat) or angiotensin II (5 ng/rat) was also inhibited by central cadmium injections. Cadmium-induced blockade in water intake in dehydrated animals was reverted by the previous administration of a S-HT2 antagonist (RP62203) in different doses (5 and 10 μg/rat). The data clearly reveal that cadmium elicits very fast actions on the central nervous system. It is suggested that cadmium-induced attenuation of water intake may rely on at least three different mechanisms: impairment of cholinergic and angiotensinergic systems in the brain and stimulation of a central serotonergic drive acting on 5-HT2 receptors. The study of cadmium neurotoxicity by observation of drinking behavior, a behavioral parameter easy to be recorded and measured, is proposed.Submitted by Suelen Reis (suelen_suzane@hotmail.com) on 2013-02-15T16:03:14Z No. of bitstreams: 1 castro.pdf: 873879 bytes, checksum: 5d3180e73e820b3ea1d7ccbbb68b1850 (MD5)Made available in DSpace on 2013-02-15T16:03:14Z (GMT). No. of bitstreams: 1 castro.pdf: 873879 bytes, checksum: 5d3180e73e820b3ea1d7ccbbb68b1850 (MD5) Previous issue date: 1996http://dx.doi.org.ez10.periodicos.capes.gov.br/10.1016/0091-3057(95)02070-5reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBACadmiumCadmium intoxicationCadmium neurotoxicityDrinking behaviorBrain angiotensinBrain cholinergic systemsBrain serotonergic systemsEffect of central acute administration of cadmium on drinking behaviorHealth Sciences Instituteinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINALcastro.pdfcastro.pdfapplication/pdf873879https://repositorio.ufba.br/bitstream/ri/8450/1/castro.pdf5d3180e73e820b3ea1d7ccbbb68b1850MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/8450/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTcastro.pdf.txtcastro.pdf.txtExtracted texttext/plain36881https://repositorio.ufba.br/bitstream/ri/8450/3/castro.pdf.txte95cb3c53d79313d6a04767cb409b70bMD53ri/84502022-07-05 14:03:01.804oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:01Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
dc.title.pt_BR.fl_str_mv |
Effect of central acute administration of cadmium on drinking behavior |
dc.title.alternative.pt_BR.fl_str_mv |
Health Sciences Institute |
title |
Effect of central acute administration of cadmium on drinking behavior |
spellingShingle |
Effect of central acute administration of cadmium on drinking behavior Silva, E. de Castro E Cadmium Cadmium intoxication Cadmium neurotoxicity Drinking behavior Brain angiotensin Brain cholinergic systems Brain serotonergic systems |
title_short |
Effect of central acute administration of cadmium on drinking behavior |
title_full |
Effect of central acute administration of cadmium on drinking behavior |
title_fullStr |
Effect of central acute administration of cadmium on drinking behavior |
title_full_unstemmed |
Effect of central acute administration of cadmium on drinking behavior |
title_sort |
Effect of central acute administration of cadmium on drinking behavior |
author |
Silva, E. de Castro E |
author_facet |
Silva, E. de Castro E Ferreira, H. Cunha, M. Bulcão, C. Sarmento, Clarissa Oliveira, I. de Fregoneze, J. B. |
author_role |
author |
author2 |
Ferreira, H. Cunha, M. Bulcão, C. Sarmento, Clarissa Oliveira, I. de Fregoneze, J. B. |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Silva, E. de Castro E Ferreira, H. Cunha, M. Bulcão, C. Sarmento, Clarissa Oliveira, I. de Fregoneze, J. B. Silva, E. de Castro E Ferreira, H. Cunha, M. Bulcão, C. Sarmento, Clarissa Oliveira, I. de Fregoneze, J. B. |
dc.subject.por.fl_str_mv |
Cadmium Cadmium intoxication Cadmium neurotoxicity Drinking behavior Brain angiotensin Brain cholinergic systems Brain serotonergic systems |
topic |
Cadmium Cadmium intoxication Cadmium neurotoxicity Drinking behavior Brain angiotensin Brain cholinergic systems Brain serotonergic systems |
description |
Texto completo: acesso restrito. p.687–693 |
publishDate |
1996 |
dc.date.issued.fl_str_mv |
1996 |
dc.date.accessioned.fl_str_mv |
2013-02-15T16:03:14Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
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http://www.repositorio.ufba.br/ri/handle/ri/8450 |
dc.identifier.issn.none.fl_str_mv |
0091-3057 |
dc.identifier.number.pt_BR.fl_str_mv |
v3 53, n. 3 |
identifier_str_mv |
0091-3057 v3 53, n. 3 |
url |
http://www.repositorio.ufba.br/ri/handle/ri/8450 |
dc.language.iso.fl_str_mv |
eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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http://dx.doi.org.ez10.periodicos.capes.gov.br/10.1016/0091-3057(95)02070-5 |
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Universidade Federal da Bahia (UFBA) |
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