Natriuretic and kaliuretic effects of central acute cadmium administration in rats

Detalhes bibliográficos
Autor(a) principal: Luz, Carla P.
Data de Publicação: 1998
Outros Autores: Silva, Emilio de Castro e, Marinho, Carol A., Castro, Letícia, Sarmento, Clarissa, Gonzalez, Virna, Oliveira, Patrícia, Nascimento, Thais, Santana Jr, Pedro, Paula, Sheila de, Lima, Ana K., Fregoneze, Josmara B.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/8209
Resumo: Texto completo: acesso restrito. p.265–272
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spelling Luz, Carla P.Silva, Emilio de Castro eMarinho, Carol A.Castro, LetíciaSarmento, ClarissaGonzalez, VirnaOliveira, PatríciaNascimento, ThaisSantana Jr, PedroPaula, Sheila deLima, Ana K.Fregoneze, Josmara B.Luz, Carla P.Silva, Emilio de Castro eMarinho, Carol A.Castro, LetíciaSarmento, ClarissaGonzalez, VirnaOliveira, PatríciaNascimento, ThaisSantana Jr, PedroPaula, Sheila deLima, Ana K.Fregoneze, Josmara B.2013-01-29T15:39:12Z19980006-8993http://www.repositorio.ufba.br/ri/handle/ri/8209v. 796, n. 1-2Texto completo: acesso restrito. p.265–272We studied the acute effects of cadmium third ventricle injections on renal excretion of water, sodium and potassium in rats previously submitted to an oral water load equivalent to 10% of their body weight. Injections of cadmium chloride (0.03, 0.3, and 3.0 nmol/rat) significantly increased sodium and potassium renal excretion without changing urine flow. Pretreatment with losartan, an angiotensin II AT1 receptor antagonist (10.8 nmol/rat into the third ventricle 10 min before central cadmium administration) inhibits the natriuretic effect of this metal, being unable to reverse its kaliuretic effect. Pretreatment with gadolinium, a calcium-channel blocker (0.3 nmol/rat into the third ventricle 20 min before central cadmium administration) abolishes both the natriuretic and the kaliuretic response of cadmium. The data clearly show that cadmium injections into the third ventricle disturb central regulation of renal function leading to an increased renal loss of sodium and potassium. It is also evident that the natriuretic action of the metal depends on an increase in brain angiotensin II release. Also, the functional integrity of calcium channels is required for the expression of both the natriuretic and the kaliuretic effects of the metal.Submitted by Suelen Reis (suelen_suzane@hotmail.com) on 2013-01-29T15:39:12Z No. of bitstreams: 1 Luz.pdf: 199179 bytes, checksum: fd7c374e74f869bbcd00897897fe528f (MD5)Made available in DSpace on 2013-01-29T15:39:12Z (GMT). No. of bitstreams: 1 Luz.pdf: 199179 bytes, checksum: fd7c374e74f869bbcd00897897fe528f (MD5) Previous issue date: 1998http://dx.doi.org/10.1016/S0006-8993(98)00250-9reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBACadmiumCadmium neurotoxicityBrain angiotensinCalcium channelLosartanGadoliniumNatriuresisKaliuresisNatriuretic and kaliuretic effects of central acute cadmium administration in ratsBrain Researchinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINALLuz.pdfLuz.pdfapplication/pdf199179https://repositorio.ufba.br/bitstream/ri/8209/1/Luz.pdffd7c374e74f869bbcd00897897fe528fMD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/8209/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTLuz.pdf.txtLuz.pdf.txtExtracted texttext/plain36044https://repositorio.ufba.br/bitstream/ri/8209/3/Luz.pdf.txtab0cef5f56cc1d476141d6f3ac38ed6cMD53ri/82092022-07-05 14:03:07.029oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:07Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Natriuretic and kaliuretic effects of central acute cadmium administration in rats
dc.title.alternative.pt_BR.fl_str_mv Brain Research
title Natriuretic and kaliuretic effects of central acute cadmium administration in rats
spellingShingle Natriuretic and kaliuretic effects of central acute cadmium administration in rats
Luz, Carla P.
Cadmium
Cadmium neurotoxicity
Brain angiotensin
Calcium channel
Losartan
Gadolinium
Natriuresis
Kaliuresis
title_short Natriuretic and kaliuretic effects of central acute cadmium administration in rats
title_full Natriuretic and kaliuretic effects of central acute cadmium administration in rats
title_fullStr Natriuretic and kaliuretic effects of central acute cadmium administration in rats
title_full_unstemmed Natriuretic and kaliuretic effects of central acute cadmium administration in rats
title_sort Natriuretic and kaliuretic effects of central acute cadmium administration in rats
author Luz, Carla P.
author_facet Luz, Carla P.
Silva, Emilio de Castro e
Marinho, Carol A.
Castro, Letícia
Sarmento, Clarissa
Gonzalez, Virna
Oliveira, Patrícia
Nascimento, Thais
Santana Jr, Pedro
Paula, Sheila de
Lima, Ana K.
Fregoneze, Josmara B.
author_role author
author2 Silva, Emilio de Castro e
Marinho, Carol A.
Castro, Letícia
Sarmento, Clarissa
Gonzalez, Virna
Oliveira, Patrícia
Nascimento, Thais
Santana Jr, Pedro
Paula, Sheila de
Lima, Ana K.
Fregoneze, Josmara B.
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Luz, Carla P.
Silva, Emilio de Castro e
Marinho, Carol A.
Castro, Letícia
Sarmento, Clarissa
Gonzalez, Virna
Oliveira, Patrícia
Nascimento, Thais
Santana Jr, Pedro
Paula, Sheila de
Lima, Ana K.
Fregoneze, Josmara B.
Luz, Carla P.
Silva, Emilio de Castro e
Marinho, Carol A.
Castro, Letícia
Sarmento, Clarissa
Gonzalez, Virna
Oliveira, Patrícia
Nascimento, Thais
Santana Jr, Pedro
Paula, Sheila de
Lima, Ana K.
Fregoneze, Josmara B.
dc.subject.por.fl_str_mv Cadmium
Cadmium neurotoxicity
Brain angiotensin
Calcium channel
Losartan
Gadolinium
Natriuresis
Kaliuresis
topic Cadmium
Cadmium neurotoxicity
Brain angiotensin
Calcium channel
Losartan
Gadolinium
Natriuresis
Kaliuresis
description Texto completo: acesso restrito. p.265–272
publishDate 1998
dc.date.issued.fl_str_mv 1998
dc.date.accessioned.fl_str_mv 2013-01-29T15:39:12Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/8209
dc.identifier.issn.none.fl_str_mv 0006-8993
dc.identifier.number.pt_BR.fl_str_mv v. 796, n. 1-2
identifier_str_mv 0006-8993
v. 796, n. 1-2
url http://www.repositorio.ufba.br/ri/handle/ri/8209
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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collection Repositório Institucional da UFBA
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