Central lead administration induces natriuretic and kaliuretic effects in rats

Detalhes bibliográficos
Autor(a) principal: Fregoneze, J. B.
Data de Publicação: 1998
Outros Autores: Luz, C. P., Gonzalez, V., Oliveira, P., Santana Junior, P., Marinho, C. A., Castro, L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/8136
Resumo: Texto completo: acesso restrito. p.321–326
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spelling Fregoneze, J. B.Luz, C. P.Gonzalez, V.Oliveira, P.Santana Junior, P.Marinho, C. A.Castro, L.Fregoneze, J. B.Luz, C. P.Gonzalez, V.Oliveira, P.Santana Junior, P.Marinho, C. A.Castro, L.2013-01-25T11:05:48Z19980031-9384http://www.repositorio.ufba.br/ri/handle/ri/8136v. 65, n. 2Texto completo: acesso restrito. p.321–326FREGONEZE, J. B., C. P. LUZ, C. SARMENTO, V. GONZALEZ, P. OLIVEIRA, P. SANTANA, JR., C. A. MARINHO, L. CASTRO, T. NASCIMENTO, S. DE PAULA, A. K. S. LIMA, I. R. DE OLIVEIRA AND E. DE CASTRO-E-SILVA. Central lead administration induces natriuretic and kaliuretic effects in rats. PHYSIOL BEHAV 65(2) 321–326, 1998.—The aim of the present experiments was to discern whether central acute lead injections affect brain control of renal function. Adult Wistar male rats received third-ventricle injections of lead acetate in three different doses (0.03, 0.3, and 3.0 nmol/rat). Lead acetate induced a significant increase in renal excretion of sodium and potassium. Pretreatment with losartan, a selective angiotensin II AT1 receptor antagonist (10.8 nmol/rat into the third ventricle 10 min before central lead injection), inhibits lead-induced natriuretic and kaliuretic effects. In addition, pretreatment with gadolinium, a calcium-channel blocker (0.3 nmol/rat into the third ventricle 20 min before central lead administration), reversed the increase in renal excretion of sodium and potassium provoked by central lead administration. Taken together, the data presented here suggest that lead injected into the third ventricle increases renal excretion of sodium and potassium by a mechanism that depends on the functional integrity of central angiotensin II AT1 receptors and calcium channels.Submitted by Suelen Reis (suelen_suzane@hotmail.com) on 2013-01-25T11:05:48Z No. of bitstreams: 1 Fregoneze.pdf: 270083 bytes, checksum: 1cade464394d779701f0e878bf234966 (MD5)Made available in DSpace on 2013-01-25T11:05:48Z (GMT). No. of bitstreams: 1 Fregoneze.pdf: 270083 bytes, checksum: 1cade464394d779701f0e878bf234966 (MD5) Previous issue date: 1998http://dx.doi.org/10.1016/S0031-9384(98)00172-3reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBALeadLead intoxicationLead neurotoxicityBrain angiotensinCalciumCalcium channelsLosartanGadoliniumNatriuresisKaliuresisCentral lead administration induces natriuretic and kaliuretic effects in ratsPhysiology and Behaviorinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINALFregoneze.pdfFregoneze.pdfapplication/pdf270083https://repositorio.ufba.br/bitstream/ri/8136/1/Fregoneze.pdf1cade464394d779701f0e878bf234966MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/8136/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTFregoneze.pdf.txtFregoneze.pdf.txtExtracted texttext/plain32516https://repositorio.ufba.br/bitstream/ri/8136/3/Fregoneze.pdf.txtb9d3e4c4877c96dd1f4fae2c65359756MD53ri/81362022-07-05 14:03:03.471oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:03Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Central lead administration induces natriuretic and kaliuretic effects in rats
dc.title.alternative.pt_BR.fl_str_mv Physiology and Behavior
title Central lead administration induces natriuretic and kaliuretic effects in rats
spellingShingle Central lead administration induces natriuretic and kaliuretic effects in rats
Fregoneze, J. B.
Lead
Lead intoxication
Lead neurotoxicity
Brain angiotensin
Calcium
Calcium channels
Losartan
Gadolinium
Natriuresis
Kaliuresis
title_short Central lead administration induces natriuretic and kaliuretic effects in rats
title_full Central lead administration induces natriuretic and kaliuretic effects in rats
title_fullStr Central lead administration induces natriuretic and kaliuretic effects in rats
title_full_unstemmed Central lead administration induces natriuretic and kaliuretic effects in rats
title_sort Central lead administration induces natriuretic and kaliuretic effects in rats
author Fregoneze, J. B.
author_facet Fregoneze, J. B.
Luz, C. P.
Gonzalez, V.
Oliveira, P.
Santana Junior, P.
Marinho, C. A.
Castro, L.
author_role author
author2 Luz, C. P.
Gonzalez, V.
Oliveira, P.
Santana Junior, P.
Marinho, C. A.
Castro, L.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Fregoneze, J. B.
Luz, C. P.
Gonzalez, V.
Oliveira, P.
Santana Junior, P.
Marinho, C. A.
Castro, L.
Fregoneze, J. B.
Luz, C. P.
Gonzalez, V.
Oliveira, P.
Santana Junior, P.
Marinho, C. A.
Castro, L.
dc.subject.por.fl_str_mv Lead
Lead intoxication
Lead neurotoxicity
Brain angiotensin
Calcium
Calcium channels
Losartan
Gadolinium
Natriuresis
Kaliuresis
topic Lead
Lead intoxication
Lead neurotoxicity
Brain angiotensin
Calcium
Calcium channels
Losartan
Gadolinium
Natriuresis
Kaliuresis
description Texto completo: acesso restrito. p.321–326
publishDate 1998
dc.date.issued.fl_str_mv 1998
dc.date.accessioned.fl_str_mv 2013-01-25T11:05:48Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/8136
dc.identifier.issn.none.fl_str_mv 0031-9384
dc.identifier.number.pt_BR.fl_str_mv v. 65, n. 2
identifier_str_mv 0031-9384
v. 65, n. 2
url http://www.repositorio.ufba.br/ri/handle/ri/8136
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1016/S0031-9384(98)00172-3
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
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collection Repositório Institucional da UFBA
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