Maternal immunization with vaccines containing recombinant NetB toxin partially protects progeny chickens from necrotic enteritis

Detalhes bibliográficos
Autor(a) principal: Keyburn, Anthony L.
Data de Publicação: 2013
Outros Autores: Portela, Ricardo Wagner Dias, Ford, Mark E., Bannam, Trudi L., Xu, X. Yan, Rood, Julian I., Moore, Robert J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/14848
Resumo: p. 1-7
id UFBA-2_953fc10be01856210904760c1e50e40c
oai_identifier_str oai:repositorio.ufba.br:ri/14848
network_acronym_str UFBA-2
network_name_str Repositório Institucional da UFBA
repository_id_str 1932
spelling Keyburn, Anthony L.Portela, Ricardo Wagner DiasFord, Mark E.Bannam, Trudi L.Xu, X. YanRood, Julian I.Moore, Robert J.2014-04-22T18:46:30Z2014-04-22T18:46:30Z20130928-4249http://repositorio.ufba.br/ri/handle/ri/14848v. 44, n. 1p. 1-7Avian necrotic enteritis is a major economic and welfare issue throughout the global poultry industry and is caused by isolates of Clostridium perfringens that produce NetB toxin. Previously we have shown that birds directly vaccinated with inactivated C. perfringens type A culture supernatant (toxoid) combined with recombinant NetB (rNetB) protein were significantly protected from homologous and heterologous challenge. In the present study the protective effect of maternal immunization was examined. Broiler breeder hens were injected subcutaneously with genetically toxoided rNetB(S254L) alone, C. perfringens type A toxoid and toxoid combined with rNetB(S254L). Vaccination resulted in a strong serum immunoglobulin Y response to NetB in hens immunized with rNetB(S254L) formulations. Anti-NetB antibodies were transferred to the eggs and on into the hatched progeny. Subclinical necrotic enteritis was induced experimentally in the progeny and the occurrence of specific necrotic enteritis lesions evaluated. Birds derived from hens immunized with rNetB(S254L) combined with toxoid and challenged with a homologous strain (EHE-NE18) at either 14 or 21 days post-hatch had significantly lower levels of disease compared to birds from adjuvant only vaccinated hens. In addition, birds from hens immunized with rNetB(S254L) alone were significantly protected when challenged at 14 days post-hatch. These results demonstrate that maternal immunization with a NetB-enhanced toxoid vaccine is a promising method for the control of necrotic enteritis in young broiler chickens.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-04-03T14:04:18Z No. of bitstreams: 1 1297-9716-44-108.pdf: 705531 bytes, checksum: 6f4d1b065bff19b91cb38b2f7ddab997 (MD5)Approved for entry into archive by Alda Lima da Silva (sivalda@ufba.br) on 2014-04-22T18:46:30Z (GMT) No. of bitstreams: 1 1297-9716-44-108.pdf: 705531 bytes, checksum: 6f4d1b065bff19b91cb38b2f7ddab997 (MD5)Made available in DSpace on 2014-04-22T18:46:30Z (GMT). No. of bitstreams: 1 1297-9716-44-108.pdf: 705531 bytes, checksum: 6f4d1b065bff19b91cb38b2f7ddab997 (MD5) Previous issue date: 2013http://dx.doi.org/10.1186/1297-9716-44-108reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAMaternal immunization with vaccines containing recombinant NetB toxin partially protects progeny chickens from necrotic enteritisVeterinary Researchinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleBrasilinfo:eu-repo/semantics/openAccessengLICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/14848/2/license.txt0d4b811ef71182510d2015daa7c8a900MD52ORIGINAL1297-9716-44-108.pdf1297-9716-44-108.pdfapplication/pdf705531https://repositorio.ufba.br/bitstream/ri/14848/1/1297-9716-44-108.pdf6f4d1b065bff19b91cb38b2f7ddab997MD51TEXT1297-9716-44-108.pdf.txt1297-9716-44-108.pdf.txtExtracted texttext/plain31570https://repositorio.ufba.br/bitstream/ri/14848/3/1297-9716-44-108.pdf.txtc68c9f37b15325f0ce813c51ef23a179MD53ri/148482022-03-23 20:15:21.748oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-03-23T23:15:21Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Maternal immunization with vaccines containing recombinant NetB toxin partially protects progeny chickens from necrotic enteritis
dc.title.alternative.pt_BR.fl_str_mv Veterinary Research
title Maternal immunization with vaccines containing recombinant NetB toxin partially protects progeny chickens from necrotic enteritis
spellingShingle Maternal immunization with vaccines containing recombinant NetB toxin partially protects progeny chickens from necrotic enteritis
Keyburn, Anthony L.
title_short Maternal immunization with vaccines containing recombinant NetB toxin partially protects progeny chickens from necrotic enteritis
title_full Maternal immunization with vaccines containing recombinant NetB toxin partially protects progeny chickens from necrotic enteritis
title_fullStr Maternal immunization with vaccines containing recombinant NetB toxin partially protects progeny chickens from necrotic enteritis
title_full_unstemmed Maternal immunization with vaccines containing recombinant NetB toxin partially protects progeny chickens from necrotic enteritis
title_sort Maternal immunization with vaccines containing recombinant NetB toxin partially protects progeny chickens from necrotic enteritis
author Keyburn, Anthony L.
author_facet Keyburn, Anthony L.
Portela, Ricardo Wagner Dias
Ford, Mark E.
Bannam, Trudi L.
Xu, X. Yan
Rood, Julian I.
Moore, Robert J.
author_role author
author2 Portela, Ricardo Wagner Dias
Ford, Mark E.
Bannam, Trudi L.
Xu, X. Yan
Rood, Julian I.
Moore, Robert J.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Keyburn, Anthony L.
Portela, Ricardo Wagner Dias
Ford, Mark E.
Bannam, Trudi L.
Xu, X. Yan
Rood, Julian I.
Moore, Robert J.
description p. 1-7
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2014-04-22T18:46:30Z
dc.date.available.fl_str_mv 2014-04-22T18:46:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/14848
dc.identifier.issn.none.fl_str_mv 0928-4249
dc.identifier.number.pt_BR.fl_str_mv v. 44, n. 1
identifier_str_mv 0928-4249
v. 44, n. 1
url http://repositorio.ufba.br/ri/handle/ri/14848
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.country.fl_str_mv Brasil
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1186/1297-9716-44-108
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
bitstream.url.fl_str_mv https://repositorio.ufba.br/bitstream/ri/14848/2/license.txt
https://repositorio.ufba.br/bitstream/ri/14848/1/1297-9716-44-108.pdf
https://repositorio.ufba.br/bitstream/ri/14848/3/1297-9716-44-108.pdf.txt
bitstream.checksum.fl_str_mv 0d4b811ef71182510d2015daa7c8a900
6f4d1b065bff19b91cb38b2f7ddab997
c68c9f37b15325f0ce813c51ef23a179
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)
repository.mail.fl_str_mv
_version_ 1808459475140476928

Registros relacionados